Hysteroscopy pp 223-230 | Cite as

Dysmorphic Uterus and Pregnancy Outcomes

  • Attilio Di Spiezio Sardo
  • Fabrizia Santangelo
  • Brunella Zizolfi
  • Marialuigia Spinelli
  • Carmine Nappi
  • Giuseppe Bifulco


The dysmorphic uteri are rare Müllerian anomalies which have been always underestimated, at the beginning supposed to be present only in case of history of DES exposure, and misdiagnosed due to a lack of clear diagnostic criteria. The new classification system of uterine anomalies from the European Society of Human Reproduction and Embryology and the European Society for Gynaecological Endoscopy includes the “dysmorphic” uteri, represented by T-shaped and tubular-shaped infantilis uteri, in Class U1. Such malformations have been proven to be associated with poor reproductive performance: increased risk of adverse outcomes in pregnancy, such as preterm delivery, SGA, sore fetal presentations, infertility, and miscarriage in the early ages. The novel Hysteroscopic Outpatient Metroplasty to Expand Dysmorphic Uteri (HOME-DU) technique for dysmorphic uteri is associated with a significant improvement of the reproductive outcomes. Macroscopic uterine changes seem to be also associated with variations of endometrial micro-environment.


Office hysteroscopy Dysmorphic uterus Hysteroscopic metroplasty T-shaped uterus Tubular uterus HOME-DU technique Reproductive outcomes 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Attilio Di Spiezio Sardo
    • 1
  • Fabrizia Santangelo
    • 2
  • Brunella Zizolfi
    • 1
  • Marialuigia Spinelli
    • 3
  • Carmine Nappi
    • 1
  • Giuseppe Bifulco
    • 2
  1. 1.Department of Public Health, School of MedicineUniversity of Naples “Federico II”NaplesItaly
  2. 2.Department of Neuroscience, Reproductive Sciences and Dentistry, School of MedicineUniversity of Naples “Federico II”NaplesItaly
  3. 3.Department of Clinical ResearchUniversity of BernBernSwitzerland

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