Abstract
Ocular tuberculosis is a chronic infection which results from bacterial dissemination from the lungs to ocular tissues followed by reactivation. It is challenging to diagnose in the absence of pulmonary tuberculosis due to absence/paucity of acid-fast bacilli (AFB). Usually with good immune response, the bacteria are killed by delayed hypersensitivity in which activated macrophages produce INF-γ and TNF-α. In case of poor immune response, the mycobacteria escape and get disseminated to the eye and other organs.
There are no well-defined criteria for the diagnosis of intraocular tuberculosis. Most of the indirect assays/tests performed on the clinical suspicion of tuberculosis lack specificity to distinguish between latent and active tuberculosis infection.
Histopathology shows granulomatous or nongranulomatous inflammation with necrosis. However, this needs to be supported by laboratory evidence in the form of AFB by microscopy/culture or mycobacterial DNA by PCR.
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Seema Sen declares no conflict of interest. No human or animal studies were carried out by the author for this chapter.
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Sen, S. (2017). Pathogenesis and Pathology of Ocular Tuberculosis. In: Kumar, A., Chawla, R., Sharma, N. (eds) Ocular Tuberculosis. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-57520-9_2
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DOI: https://doi.org/10.1007/978-3-319-57520-9_2
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