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Cervical Cancer PDOX Models

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Patient-Derived Mouse Models of Cancer

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

We describe here patient-derived orthotopic xenograft (PDOX) models of cervical cancer in nude mice. The PDOX models metastasized in a similar pattern as the patient, including lymph nodes, liver, lungs and peritoneum. Most importantly, the drug, entinostat, was active against the metastasis and not the primary tumor or a subcutaneous model, which did not metastasize. In another cervical cancer PDOX, the generic drug, cisplatinum, was active in comparison with an expensive patented drug, NAB-paclitaxel, which was not. The models described in this chapter should be of use to individualize and make more precise and effective treatment for patients with metastatic cervical cancer.

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Authors and Affiliations

  1. AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA, 92111, USA

    Robert M. Hoffman, Yukihiko Hiroshima & Takashi Murakami

  2. Department of Surgery, University of California, San Diego, La Jolla, CA, USA

    Robert M. Hoffman, Yukihiko Hiroshima & Takashi Murakami

  3. Department of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan

    Yukihiko Hiroshima & Takashi Murakami

  4. Department of Obstetrics and Gynecology, Kawasaki Medical School, Okayama, Japan

    Takuya Murata

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  1. Robert M. Hoffman
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  2. Yukihiko Hiroshima
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  3. Takashi Murakami
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  4. Takuya Murata
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Correspondence to Robert M. Hoffman .

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  1. University of California and AntiCancer Inc., San Diego, California, USA

    Robert M. Hoffman

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Hoffman, R.M., Hiroshima, Y., Murakami, T., Murata, T. (2017). Cervical Cancer PDOX Models. In: Hoffman, R. (eds) Patient-Derived Mouse Models of Cancer . Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-57424-0_10

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  • DOI: https://doi.org/10.1007/978-3-319-57424-0_10

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-57423-3

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