Skip to main content
SpringerLink
Log in

Delayed Puberty

  • Chapter
  • First Online:
Good Practice in Pediatric and Adolescent Gynecology

  • 933 Accesses

Abstract

Delayed puberty is a heterogeneous condition related to different underlying causes affecting hypothalamic-pituitary axis, with different impact on the general health. The chapter provides an overview of the pathophysiology of pubertal impairment, comprehensive of the possible clues of specific disorders, of diagnostic workup and of specific therapeutic approaches. It should also be kept in mind that an aberration in the proper pubertal timing has a significant impact on psychological health of the girl, so a proper definition is mandatory.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

AMH:

Anti-Mullerian hormone

CD:

Coeliac disease

CDGP:

Constitutional delay of growth and puberty

CSF:

Cerebrospinal fluid

DP:

Delayed puberty

FHH:

Functional hypogonadotropic hypogonadism

FSH:

Follicle stimulating hormone

GD:

Growth hormone deficiency

Gh:

Growth hormone

GhRH:

Growth hormone releasing hormone

GnRH:

Gonadotropin hormone releasing hormone

HH:

Hypogonadotropic hypogonadism

IGD:

Isolated Gh deficiency

IGF-1:

Insulin growth factor-1

KS:

Kallmann syndrome

LH:

Luteotropic hormone

PRL:

Prolactin

SSRI:

Selective serotonin reuptake inhibitors

TIDA:

Tuberoinfundibular dopamineagonists

References

  1. Raivio T, Falardeau J, Dwyer A, Quinton R, et al. Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med. 2007;357:863–73.

    Article  CAS  PubMed  Google Scholar 

  2. Beate K, Joseph N, de Roux N, Wolfram K. Genetics of isolated hypogonadotropic hypogonadism: role of GnRH receptor and other genes. Int J Endocrinol. 2012;2012:147893.

    Google Scholar 

  3. Reynaud R, Castinetti F, Galon-Faure N, Albarel-Loy F, Saveanu A, et al. Genetic aspects of growth hormone deficiency. Arch Pediatr. 2011;18(6):696–706.

    Article  CAS  PubMed  Google Scholar 

  4. Limdi JK, Crampton JR. Hereditary haemochromatosis. QJ Med. 2004;97:315–24.

    Article  CAS  Google Scholar 

  5. Müller HL, Sörensen N. Childhood craniopharyngioma recent advances in diagnosis and treatment. Dtsch Arztebl. 2006;103(40):A2634–40.

    Google Scholar 

  6. Rose SR, Auble BA. Endocrine changes after pediatric traumatic brain injuries. Pituitary. 2012;15:267–75.

    Article  CAS  PubMed  Google Scholar 

  7. NICE. Coeliac disease. Recognition, assessment and management. Clinical Guideline NG20; 2015.

    Google Scholar 

  8. Pozo J, Argente J. Delayed puberty in chronic illness. Best Pract Res Clin Endocrinol Metab. 2002;16(1):73–90.

    Article  CAS  PubMed  Google Scholar 

  9. Toppari J, Juul A. Trends in puberty timing in humans and environmental modifiers. Mol Cell Endocrinol. 2010;324(1–2):39–44.

    Article  CAS  PubMed  Google Scholar 

  10. Martin DD, Wit JM, Hochberg Z, Savandahal L, van Rijin R, Cameron N, et al. The use of bone age in clinical practice—part 1. Horm Res Paediatr. 2011;76:1–9.

    Article  CAS  PubMed  Google Scholar 

  11. Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(2):273–88.

    Article  CAS  PubMed  Google Scholar 

  12. Binder G, Schweizer R, Haber P, Blumenstock G, Braun R. Accuracy of endocrine tests for detecting hyogonadotropinìc hypogonadism in girls. J Pediatr. 2015;167(3):674–8.

    Article  CAS  PubMed  Google Scholar 

  13. Löfqvist C, Andersson E, Gelander L, Rosberg S, Blum WF, Albertsson Wikland K. Reference values for IGF-I throughout childhood and adolescence: a model that accounts simultaneously for the effect of gender, age, and puberty. J Clin Endocrinol Metab. 2001;86(12):5870–6.

    Article  PubMed  Google Scholar 

  14. Bandini LG, Must A, Naumova EN, Anderson S, Caprio S, et al. Change in leptin, body composition and other hormones around menarche—a visual representation. Acta Paediatr. 2008;97(10):1454–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Harrington J, Palmert RM. Clinical review: distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. J Clin Endocrinol Metab. 2012;97(9):3056–67.

    Article  CAS  PubMed  Google Scholar 

  16. Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, Quinton R, Young J. Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment. Nat Rev Endocrinol. 2015;11(9):547–64.

    PubMed  Google Scholar 

  17. Ankarberg-Lindgren C, Kriström B, Norjavaara E. Physiological estrogen replacement therapy for puberty induction in girls: a clinical observational study. Horm Res Paediatr. 2014;81(4):239–44.

    Article  CAS  PubMed  Google Scholar 

  18. Peuskens J, Rubio G, Schreiner A. Dosing and switching of paliperidone ER in patients patients with schizophrenia: recommendations for clinical practice. Ann Gen Psychiatry. 2014;13(1):10.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Wehkalampi K, Päkkilä K, Laine T, Dunkel L. Adult height in girls with delayed pubertal growth. Horm Res Paediatr. 2011;76(2):130–5.

    Article  CAS  PubMed  Google Scholar 

  20. Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2010;95(9):4133–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Italian Society of Pediatric and Adolescent Gynecology, Florence, Italy

    Metella Dei M.D.

  2. Pediatric and Adolescent Gynecology Unit, Careggi Hospital, Florence, Italy

    Francesca Pampaloni M.D.

Authors
  1. Metella Dei M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesca Pampaloni M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Metella Dei M.D. .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Cagliari, Cagliari, Italy

    Anna Maria Fulghesu

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Dei, M., Pampaloni, F. (2018). Delayed Puberty. In: Fulghesu, A. (eds) Good Practice in Pediatric and Adolescent Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-319-57162-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-57162-1_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-57161-4

  • Online ISBN: 978-3-319-57162-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation