System Modeling of Receptor-Induced Apoptosis
Receptor-induced apoptosis is a complex signal transduction pathway involving numerous protein–protein interactions and post-translational modifications. The response to death receptor stimulation varies significantly from one cell line to another and even from one cell to another within a given cell line. In this context, it is often difficult to assess whether the molecular mechanisms identified so far are sufficient to explain the rich quantitative observations now available, and to detect possible gaps in our understanding. This is precisely where computational systems biology approaches may contribute. In this chapter, we review studies done in this direction, focusing on those that provided a significant insight on the functioning of this complex pathway by tightly integrating experimental and computational approaches.
KeywordsComputational systems biology Signal transduction models Receptor-induced apoptosis Modeling cell types Modeling phenotypic heterogeneity
This work was supported by the research grants Syne2arti ANR-10-COSINUS-007 and Investissements d’Avenir Iceberg ANR-IABI-3096 from the French National Research Agency.
- 1.Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N (2014) Apoptosis and molecular targeting therapy in cancer. Biomed Res Int 2014:150823–150845Google Scholar
- 35.Schmid J, Dussmann H, Boukes GJ, Flanagan L, Lindner AU, O’Connor CL, Rehm M, Prehn JHM, Huber HJ (2012) Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization. J Biol Chem 287:41546–41559CrossRefPubMedPubMedCentralGoogle Scholar