• Sergio Canavero
  • Vincenzo Bonicalzi


The anatomophysiological “engine” of CP is a focal, self-sustaining, reverberating loop between the sensory cortex and the sensory thalamus (Dynamic Reverberation, DR) ([1], Figs. 8.1 and 8.2), following the establishment of an intracortical S1 attractor state (locked S1) (e.g., layer 4⇒ (layer 2/3⇒) layer 5⇒ layer 6⇒ layer 4+corticothalamic outflow). The attendant sensory information decorrelation translates into different sensory percepts (pain, dysesthesias, paresthesias, pruritus).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sergio Canavero
    • 1
  • Vincenzo Bonicalzi
    • 2
  1. 1.HEAVEN/GEMINI International Collaborative GroupTurinItaly
  2. 2.AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi MontalciniUniversità di TorinoTurinItaly

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