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Genesis

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Central Pain Syndrome

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Abstract

The anatomophysiological “engine” of CP is a focal, self-sustaining, reverberating loop between the sensory cortex and the sensory thalamus (Dynamic Reverberation, DR) ([1], Figs. 8.1 and 8.2), following the establishment of an intracortical S1 attractor state (locked S1) (e.g., layer 4⇒ (layer 2/3⇒) layer 5⇒ layer 6⇒ layer 4+corticothalamic outflow). The attendant sensory information decorrelation translates into different sensory percepts (pain, dysesthesias, paresthesias, pruritus).

New scientific ideas never spring from a communal body, however organized, but rather from the head of an individually inspired researcher who struggles with his problems in lonely thought and unites all his thought on one single point which is his whole world for the moment.

Max Planck

(25th anniversary of the Kaiser-Wilhelm Gesellschaft, January 1936)

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  1. HEAVEN/GEMINI International Collaborative Group, Turin, Italy

    Sergio Canavero

  2. AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi Montalcini, Università di Torino, Turin, Italy

    Vincenzo Bonicalzi

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Canavero, S., Bonicalzi, V. (2018). Genesis. In: Central Pain Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-56765-5_8

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