Curative Surgery and Other Experimental Approaches

  • Sergio Canavero
  • Vincenzo Bonicalzi


The evidence reviewed in the genesis chapter makes a strong case for CP being the result of a localized “locked” reverberating loop between the somatosensory cortex and the sensory thalamus (Dynamic Reverberation). In those cases with complete S1 or thalamic destruction, the reverberant loop is activated in the opposite hemisphere. In this model, the outflow down the facilitatory cortico(S1)-thalamic fiber system, no longer held in check by appropriate cortical inhibitory control, feeds continuously into the thalamus, thereby engaging an out-of-balance “pain loop.” The truncoreticulo-propriospinal pathway (TRPS) becomes hyperactive after CNS injuries and provides bilateral bottom-up facilitation to the loop and simultaneously is fed by descending cortical facilitation.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sergio Canavero
    • 1
  • Vincenzo Bonicalzi
    • 2
  1. 1.HEAVEN/GEMINI International Collaborative GroupTurinItaly
  2. 2.AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi MontalciniUniversità di TorinoTurinItaly

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