Several other molecules have been tried for CP. NSAIDs are useless, but tried by the vast majority of patients. Botulinum, which has pleiotropic actions (substance P/CGRP and glutamate block), and may have unexpected central effects, is interesting, but its effects are modest at best. Cholinergics (e.g., donepezil) have not been adequately tested, but may play some role as add-on therapy. Misoprostol (200 μg tid) is effective for MS-related trigeminal neuralgia (e.g., ). For other agents, the body of evidence is too thin to make any conclusion.
Unable to display preview. Download preview PDF.
- 9.Rascol O, Zesiewicz T, Chaudhuri KR, Asgharnejad M, Surmann E, Dohin E, Nilius S, Bauer L. A randomized controlled exploratory pilot study to evaluate the effect of rotigotine transdermal patch on Parkinson’s disease-associated chronic pain. J Clin Pharmacol. 2016;56(7):852–61.CrossRefPubMedGoogle Scholar
- 10.Di Biagio F. Dolore centrale da lesione sopratalamica regredito con atophanyl. Riv Neurol. 1959;29:476–81.Google Scholar
- 18.Ringelstein M, Ayzenberg I, Harmel J, Lauenstein AS, Lensch E, Stögbauer F, Hellwig K, Ellrichmann G, Stettner M, Chan A, Hartung HP, Kieseier B, Gold R, Aktas O, Kleiter I. Long-term therapy with interleukin 6 receptor blockade in highly active neuromyelitis optica spectrum disorder. JAMA Neurol. 2015;72(7):756–63.CrossRefPubMedGoogle Scholar