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Desmoid (Aggressive) Fibromatosis of the Breast

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Breast Cancer Management for Surgeons

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Abstract

Desmoid fibromatosis (DF) is a rare intermediate soft tissue tumour characterised by myofibroblastic cell proliferation. Although desmoid tumours are locally very infiltrative, they hold no metastatic potential, and a significant proportion of cases naturally regress if simply observed. Considering this, a first-line policy of active observation should be adopted in all cases (with appropriate analgesia as required). If disease progression or symptoms require intervention, several other non-surgical treatments, including radiotherapy and chemotherapy, should be considered prior to surgery. This makes close collaboration with a soft tissue tumour MDT essential when managing these complex patients.

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Author information

Authors and Affiliations

  1. University Hospitals of Leicester NHS Trust, Department of Orthopaedics, Leicester Royal Infirmary, Leicester, UK

    Nicholas C. Eastley MBCHB, BMedSci, MRCS

  2. University Hospitals of Leicester NHS Trust, Department of Breast Surgery, Glenfield Hospital, Leicester, UK

    Jaroslaw Krupa MD, PhD

  3. East Midlands Sarcoma Service, Leicester Royal Infirmary, Leicester, UK, LE1 5WW

    Robert U. Ashford MB BS, MD, FRCS (Tr & Orth)

Authors
  1. Nicholas C. Eastley MBCHB, BMedSci, MRCS
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  2. Jaroslaw Krupa MD, PhD
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  3. Robert U. Ashford MB BS, MD, FRCS (Tr & Orth)
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Corresponding author

Correspondence to Robert U. Ashford MB BS, MD, FRCS (Tr & Orth) .

Editor information

Editors and Affiliations

  1. The Medical School Department of Oncology, University of Sheffield, Sheffield, United Kingdom

    Lynda Wyld

  2. Athens University Medical School, Athens, Greece

    Christos Markopoulos

  3. Helsinki University Hospital, Helsinki, Finland

    Marjut Leidenius

  4. Department of Oncology & Radiotherapy, Gdańsk Medical University Department of Oncology & Radiotherapy, Gdańsk, Poland

    Elżbieta Senkus-Konefka

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Eastley, N.C., Krupa, J., Ashford, R.U. (2018). Desmoid (Aggressive) Fibromatosis of the Breast. In: Wyld, L., Markopoulos, C., Leidenius, M., Senkus-Konefka, E. (eds) Breast Cancer Management for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-56673-3_47

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  • DOI: https://doi.org/10.1007/978-3-319-56673-3_47

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56671-9

  • Online ISBN: 978-3-319-56673-3

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