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Immediate Reconstruction: General and Oncological Considerations

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Abstract

Breast cancer treatments have undergone major improvements in the last 20 years. Breast conservation is now possible and desirable for the majority of women, and axillary dissection has been progressively replaced by sentinel node biopsy. However, some patients will still be advised to, or choose to, have a mastectomy. European guidelines recommend that every woman facing a mastectomy should be offered breast reconstruction, if appropriate, either immediate or delayed, taking into account patient and tumour factors and individual preferences.

Immediate breast reconstruction (IBR) has become a widely available option, and apart from inflammatory breast cancer, there are no other absolute contraindications to the procedure if desired by the patient. Postmastectomy radiotherapy (PMRT) does have an impact on outcome but is considered only as a relative contraindication to IBR. The choice of the technique for IBR is complex and should consider the optimal cosmetic outcome balanced against surgical morbidity and without compromising adjuvant treatments.

Measures of quality of life and cosmetic outcome are scarce and lack uniformity. However, they need to be recorded so that results can be evaluated and compared in an objective manner. The use of decision trees, with the inclusion of the more important factors involved in the process, can aid a more informed choice and reduce morbidity.

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References

  1. Goldwyn RM. Vincenz Czerny and the beginnings of breast reconstruction. Plast Reconstr Surg. 1978;61(5):673–81.

    Article  CAS  PubMed  Google Scholar 

  2. Halsted WS. I. The results of radical operations for the cure of carcinoma of the breast. Ann Surg. 1907;46(1):1–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rosato FE, Horton CE, Maxwell GP. Postmastectomy breast reconstruction. Curr Probl Surg. 1980;17(11):585–629.

    Article  CAS  PubMed  Google Scholar 

  4. Bostwick J 3rd, Scheflan M. The latissimus dorsi musculocutaneous flap: a one-stage breast reconstruction. Clin Plast Surg. 1980;7(1):71–8.

    PubMed  Google Scholar 

  5. Radovan C. Breast reconstruction after mastectomy using the temporary expander. Plast Reconstr Surg. 1982;69(2):195–208.

    Article  CAS  PubMed  Google Scholar 

  6. Becker H. Breast reconstruction using an inflatable breast implant with detachable reservoir. Plast Reconstr Surg. 1984;73(4):678–83.

    Article  CAS  PubMed  Google Scholar 

  7. Hartrampf CR, Scheflan M, Black PW. Breast reconstruction with a transverse abdominal island flap. Plast Reconstr Surg. 1982;69(2):216–25.

    Article  CAS  PubMed  Google Scholar 

  8. D’Souza N, Darmanin G, Fedorowicz Z. Immediate versus delayed reconstruction following surgery for breast cancer. Cochrane Database Syst Rev. 2011;(7):CD008674.

    Google Scholar 

  9. NCI. Breast reconstruction 2013 [updated February 2013]. Available from: http://www.cancer.gov/types/breast/reconstruction-fact-sheet.

  10. NCCN. NCCN Guidelines for Invasive Breast Cancer. Principles of breast reconstruction for invasive breast cancer; [191]. 2016.

    Google Scholar 

  11. Tryfonidis K, Senkus E, Cardoso MJ, Cardoso F. Management of locally advanced breast cancer-perspectives and future directions. Nat Rev Clin Oncol. 2015;12(3):147–62.

    Article  PubMed  Google Scholar 

  12. Senkus E, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rutgers E, et al. Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(Suppl 5):v8–30.

    Article  PubMed  Google Scholar 

  13. Cawthorn S, Cutress RDH, Harcourt D, O’Donoghue J, Rainsbury D, Sjeppard C, et al. Oncoplastic breast reconstruction: guidelines for best practice. British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS); Association of Breast Surgery; 2012, pp. 1–68.

    Google Scholar 

  14. Berbers J, van Baardwijk A, Houben R, Heuts E, Smidt M, Keymeulen K, et al. ‘Reconstruction: before or after postmastectomy radiotherapy?’ A systematic review of the literature. Eur J Cancer. 2014;50(16):2752–62.

    Article  PubMed  Google Scholar 

  15. Fischer JP, Wes AM, Tuggle CT, Nelson JA, Tchou JC, Serletti JM, et al. Mastectomy with or without immediate implant reconstruction has similar 30-day perioperative outcomes. J Plast Reconstr Aesthet Surg. 2014;67(11):1515–22.

    Article  PubMed  Google Scholar 

  16. Jagsi R, Jiang J, Momoh AO, Alderman A, Giordano SH, Buchholz TA, et al. Complications after mastectomy and immediate breast reconstruction for breast cancer: a claims-based analysis. Ann Surg. 2016;263(2):219–27.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Xavier Harmeling J, Kouwenberg CA, Bijlard E, Burger KN, Jager A, Mureau MA. The effect of immediate breast reconstruction on the timing of adjuvant chemotherapy: a systematic review. Breast Cancer Res Treat. 2015;153(2):241–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hamahata A, Kubo K, Takei H, Saitou T, Hayashi Y, Matsumoto H, et al. Impact of immediate breast reconstruction on postoperative adjuvant chemotherapy: a single center study. Breast Cancer. 2015;22(3):287–91.

    Article  PubMed  Google Scholar 

  19. Eck DL, McLaughlin SA, Terkonda SP, Rawal B, Perdikis G. Effects of immediate reconstruction on adjuvant chemotherapy in breast cancer patients. Ann Plast Surg. 2015;74(Suppl 4):S201–3.

    Article  CAS  PubMed  Google Scholar 

  20. Gieni M, Avram R, Dickson L, Farrokhyar F, Lovrics P, Faidi S, et al. Local breast cancer recurrence after mastectomy and immediate breast reconstruction for invasive cancer: a meta-analysis. Breast. 2012;21(3):230–6.

    Article  CAS  PubMed  Google Scholar 

  21. Eriksen C, Frisell J, Wickman M, Lidbrink E, Krawiec K, Sandelin K. Immediate reconstruction with implants in women with invasive breast cancer does not affect oncological safety in a matched cohort study. Breast Cancer Res Treat. 2011;127(2):439–46.

    Article  CAS  PubMed  Google Scholar 

  22. Fischer JP, Wes AM, Tuggle CT, Serletti JM, Wu LC. Risk analysis and stratification of surgical morbidity after immediate breast reconstruction. J Am Coll Surg. 2013;217(5):780–7.

    Article  PubMed  Google Scholar 

  23. Song J, Zhang X, Liu Q, Peng J, Liang X, Shen Y, et al. Impact of neoadjuvant chemotherapy on immediate breast reconstruction: a meta-analysis. PLoS One. 2014;9(5):e98225.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Abt NB, Flores JM, Baltodano PA, Sarhane KA, Abreu FM, Cooney CM, et al. Neoadjuvant chemotherapy and short-term morbidity in patients undergoing mastectomy with and without breast reconstruction. JAMA Surg. 2014;149(10):1068–76.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Dolen UC, Schmidt AC, Um GT, Sharma K, Naughton M, Zoberi I, et al. Impact of neoadjuvant and adjuvant chemotherapy on immediate tissue expander breast reconstruction. Ann Surg Oncol. 2016;23(7):2357–66.

    Google Scholar 

  26. Caffo O, Cazzolli D, Scalet A, Zani B, Ambrosini G, Amichetti M, et al. Concurrent adjuvant chemotherapy and immediate breast reconstruction with skin expanders after mastectomy for breast cancer. Breast Cancer Res Treat. 2000;60(3):267–75.

    Article  CAS  PubMed  Google Scholar 

  27. Myckatyn TM, Cavallo JA, Sharma K, Gangopadhyay N, Dudas JR, Roma AA, et al. The impact of chemotherapy and radiation therapy on the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction. Plast Reconstr Surg. 2015;135(1):43e–57e.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. EBCTCG, McGale P, Taylor C, Correa C, Cutter D, Duane F, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 2014;383(9935):2127–35.

    Article  Google Scholar 

  29. Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, et al. Tailoring therapies – improving the management of early breast cancer: St Gallen international expert consensus on the primary therapy of early breast cancer 2015. Ann Oncol. 2015;26(8):1533–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Pavy JJ, Denekamp J, Letschert J, Littbrand B, Mornex F, Bernier J, et al. EORTC Late Effects Working Group. Late effects toxicity scoring: the SOMA scale. Int J Radiat Oncol Biol Phys. 1995;31(5):1043–7.

    Article  CAS  PubMed  Google Scholar 

  31. Lam TC, Hsieh F, Boyages J. The effects of postmastectomy adjuvant radiotherapy on immediate two-stage prosthetic breast reconstruction: a systematic review. Plast Reconstr Surg. 2013;132(3):511–8.

    Article  CAS  PubMed  Google Scholar 

  32. Barry M, Kell MR. Radiotherapy and breast reconstruction: a meta-analysis. Breast Cancer Res Treat. 2011;127(1):15–22.

    Article  CAS  PubMed  Google Scholar 

  33. Schaverien MV, Macmillan RD, McCulley SJ. Is immediate autologous breast reconstruction with postoperative radiotherapy good practice?: a systematic review of the literature. J Plast Reconstr Aesthet Surg. 2013;66(12):1637–51.

    Article  PubMed  Google Scholar 

  34. Valdatta L, Cattaneo AG, Pellegatta I, Scamoni S, Minuti A, Cherubino M. Acellular dermal matrices and radiotherapy in breast reconstruction: a systematic review and meta-analysis of the literature. Plast Surg Int. 2014;2014:472604.

    PubMed  PubMed Central  Google Scholar 

  35. Chen CM, Cano SJ, Klassen AF, King T, McCarthy C, Cordeiro PG, et al. Measuring quality of life in oncologic breast surgery: a systematic review of patient-reported outcome measures. Breast J. 2010;16(6):587–97.

    Article  PubMed  Google Scholar 

  36. Winters ZE, Balta V, Thomson HJ, Brandberg Y, Oberguggenberger A, Sinove Y, et al. Phase III development of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire module for women undergoing breast reconstruction. Br J Surg. 2014;101(4):371–82.

    Article  CAS  PubMed  Google Scholar 

  37. Heneghan HM, Prichard RS, Lyons R, Regan PJ, Kelly JL, Malone C, et al. Quality of life after immediate breast reconstruction and skin-sparing mastectomy – a comparison with patients undergoing breast conserving surgery. Eur J Surg Oncol. 2011;37(11):937–43.

    Article  CAS  PubMed  Google Scholar 

  38. Nava MB, Rocco N, Catanuto G. Conservative mastectomies: an overview. Gland Surg. 2015;4(6):463–6.

    PubMed  PubMed Central  Google Scholar 

  39. van Verschuer VM, Mureau MA, Gopie JP, Vos EL, Verhoef C, Menke-Pluijmers MB, et al. Patient satisfaction and nipple-areola sensitivity after bilateral prophylactic mastectomy and immediate implant breast reconstruction in a high breast cancer risk population: nipple-sparing mastectomy versus skin-sparing mastectomy. Ann Plast Surg. 2016;77(2):145–52.

    Google Scholar 

  40. Wei CH, Scott AM, Price AN, Miller HC, Klassen AF, Jhanwar SM, et al. Psychosocial and sexual well-being following nipple-sparing mastectomy and reconstruction. Breast J. 2016;22(1):10–7.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Cardoso MJ, Cardoso JS, Vrieling C, Macmillan D, Rainsbury D, Heil J, et al. Recommendations for the aesthetic evaluation of breast cancer conservative treatment. Breast Cancer Res Treat. 2012;135(3):629–37.

    Article  PubMed  Google Scholar 

  42. Cardoso MJ, Cardoso J, Amaral N, Azevedo I, Barreau L, Bernardo M, et al. Turning subjective into objective: the BCCT.Core software for evaluation of cosmetic results in breast cancer conservative treatment. Breast. 2007;16(5):456–61.

    Article  PubMed  Google Scholar 

  43. Catanuto G, Rocco N, Nava MB. Surgical decision making in conservative mastectomies. Gland Surg. 2016;5(1):69–74.

    PubMed  PubMed Central  Google Scholar 

  44. Longo B, Farcomeni A, Ferri G, Campanale A, Sorotos M, Santanelli F. The BREAST-V: a unifying predictive formula for volume assessment in small, medium, and large breasts. Plast Reconstr Surg. 2013;132(1):1e–7e.

    Article  CAS  PubMed  Google Scholar 

  45. Kim MS, Reece GP, Beahm EK, Miller MJ, Atkinson EN, Markey MK. Objective assessment of aesthetic outcomes of breast cancer treatment: measuring ptosis from clinical photographs. Comput Biol Med. 2007;37(1):49–59.

    Article  PubMed  Google Scholar 

  46. Berwick DM, Nolan TW, Whittington J. The triple aim: care, health, and cost. Health Aff (Millwood). 2008;27(3):759–69.

    Article  Google Scholar 

  47. Krumholz HM. Informed consent to promote patient-centered care. JAMA. 2010;303(12):1190–1.

    Article  CAS  PubMed  Google Scholar 

  48. Nava MB, Ottolenghi J, Pennati A, Spano A, Bruno N, Catanuto G, et al. Skin/nipple sparing mastectomies and implant-based breast reconstruction in patients with large and ptotic breast: oncological and reconstructive results. Breast. 2012;21(3):267–71.

    Article  PubMed  Google Scholar 

  49. della Rovere GQ, Nava M, Bonomi R, Catanuto G, Benson JR.  Skin-reducing mastectomy with breast reconstruction and sub-pectoral implants. J Plast Reconstr Aesthet Surg. 2008;61(11):1303–8.

    Article  PubMed  Google Scholar 

  50. Losken A, Carlson GW, Bostwick J 3rd, Jones GE, Culbertson JH, Schoemann M. Trends in unilateral breast reconstruction and management of the contralateral breast: the Emory experience. Plast Reconstr Surg. 2002;110(1):89–97.

    Article  PubMed  Google Scholar 

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Correspondence to Maria João Cardoso MD, PhD .

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Cardoso, M.J., Catanuto, G. (2018). Immediate Reconstruction: General and Oncological Considerations. In: Wyld, L., Markopoulos, C., Leidenius, M., Senkus-Konefka, E. (eds) Breast Cancer Management for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-56673-3_27

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  • DOI: https://doi.org/10.1007/978-3-319-56673-3_27

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