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Abstract

There are foods that are healthy, and there are many that are not. Many forms of cancer can be prevented by dietary and lifestyle changes, and eating good foods can aid in recovery from cancer. A healthy person will do better than an unhealthy one. The foods we eat everyday have been formed largely by habit. Thus changes to eating patterns will take practice to form new habits. This chapter examines the evidence that diet does contribute to cancer, and about foods that may assist in preventing cancer, as well as assisting patients with cancer. This includes foods that may be added to diet and those which should be minimised or eliminated. It sets out thirteen dietary principles that may be discussed with the patient, and incorporated into a Wellness Plan.

Let thy food be thy medicine and thy medicine be thy food.

Hippocrates.

In Chinese medicine, diet therapy is the highest form of medicine .

Various Chinese medical texts.

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References

  1. Alexander W. Prostate cancer risk and omega-3 fatty acid intake from fish oil. Pharm Ther. 2013;38(9):561–4.

    Google Scholar 

  2. Ahmed R, Segal I, Hassan H. Fermentation of dietary starch in humans. Am J Gastroenterol. 2000;95(4):1017–20.

    Article  CAS  PubMed  Google Scholar 

  3. Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fibre cereal supplement on the recurrence of colorectal adenomas. Phoenix colon cancer prevention physicians’ network. N Engl J Med. 2000;342(16):1156–62.

    Article  CAS  PubMed  Google Scholar 

  4. Allen NE, Appleby PN, Davey GK, et al. Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men. Brit J Cancer. 2000;83:95–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Allen NE, Beral V, Casabonne D, et al. Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst. 2009;101(5):296–305.

    Article  PubMed  Google Scholar 

  6. Althius MD, Dozier JM, Anderson WF, et al. Global trends in breast cancer incidence and mortality 1973-1997. Int J Epidemiol. 2005;34(2):405–12.

    Article  Google Scholar 

  7. Anand P, Kunnumakara AB, Sundarum C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25(9):2097–116.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Aragon F, Perdigon G, de Moreno de LeBlanc A. Modification in the diet can induce beneficial effects against breast cancer. World J Clin Oncol. 2014;5(3):455–64.

    Google Scholar 

  9. Armstrong D, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975;15:617–31.

    Article  CAS  PubMed  Google Scholar 

  10. Aucoin M, Cooley K, Knee C et al. Fish-derived omega-3 fatty acids and prostate cancer: a systematic review. Integr Cancer Ther. 2016. pii: 1534735416656052. [Epub ahead of print].

    Google Scholar 

  11. Augustin LS, Gallus S, Franceschi S, et al. Glycemic index and load and risk of upper aero-digestive tract neoplasms. Cancer Causes Control. 2003;14:657–62.

    Article  PubMed  Google Scholar 

  12. Augustin LS, Gallus S, Borsetti C, et al. Glycemic index and glycemic load in endometrial cancer. Int J Cancer. 2003;105:404–7.

    Article  CAS  PubMed  Google Scholar 

  13. Augustin LS, Polese J, Borsetti C, et al. Dietary glycemic index, glycemic load and ovarian cancer risk: a case-control study in Italy. Ann Oncol. 2003;14:78–84.

    Article  CAS  PubMed  Google Scholar 

  14. Augustin LS, Gallus S, Negri E, La Vecchia C. Glycemic index, glycemic load and risk of gastric cancer. Ann Oncol. 2004;15:581–4.

    Article  CAS  PubMed  Google Scholar 

  15. Aune D, Chan DSM, Lau R, et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2011;343:d6617.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Aune D, Chan DS, Greenwood DC, et al. Dietary fibre and breast cancer risk: a systematic review and meta-analysis of prospective studies. Ann Oncol. 2012;23(6):1394–402.

    Article  CAS  PubMed  Google Scholar 

  17. Australian Government. Australian dietary guidelines 2013. Available at https://www.eatforhealth.gov.au/sites/default/files/files/the_guidelines/n55_australian_dietary_guidelines.pdf. Accessed 5 Aug 2016.

  18. Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B. Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. Oncol Res. 2000;12(1):83–95.

    CAS  PubMed  Google Scholar 

  19. Bamia C, Lagiou P, Jenab M, et al. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study. Int J Cancer. 2015;136(8):1899–908.

    Article  CAS  PubMed  Google Scholar 

  20. Bao Y, Han J, Hu FB, et al. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 2013;369:2001–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Baranski M, Srednicka-Tober D, Volakakis N, et al. Higher antioxidant and lower cadmium concentrations and lower incidence of pesticide residues in organically grown crops: a systematic literatures review and meta-analyses. Br J Nutr. 2014;112(5):794–811.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Barnard RJ, Gonzalez JH, Liva ME, Ngo TH. Effects of a low-fat, high-fibre diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutr Cancer. 2006;55(1):28–34.

    Article  CAS  PubMed  Google Scholar 

  23. Bartoli R, Fernandez-Banares F, Navarro E et al. Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E2 synthesis. Gut. 2000;46:191–9.

    Google Scholar 

  24. Baseline of Health Foundation. Healthiest cooking oil comparison chart with smoke points and omega 3 fatty acid ratios. 2012. https://jonbarron.org/diet-and-nutrition/healthiest-cooking-oil-chart-smoke-points. Accessed 20 Aug 2016.

  25. Bassin EB. Association between fluoride in drinking water during growth and development and the incidence of osteosarcoma for children and adolescents. DMSc thesis, Harvard School of Dental Medicine, Boston, Massachusetts, 2001. In Connett P, Beck J, Micklem HS. The Case Against Fluoride. Vermont: Chelsea Green Publishing; 2010.

    Google Scholar 

  26. Benetou V, Trichoploulou A, Orfanos P, et al. Conformity to traditional Mediterranean diet and cancer incidence: the Greek EPIC cohort. Brit J Cancer. 2008;99:191–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Bianchini F, Kaaks R, Vainio H. Overweight, obesity, and cancer risk. Lancet. 2002;3(9):565–74.

    Article  PubMed  Google Scholar 

  28. Beresford SA, Johnson KC, Ritenbaugh C, et al. Low-fat dietary pattern and risk of colorectal cancer: the women’s health initiative randomized controlled dietary modification trial. JAMA. 2006;295(6):643–54.

    Article  CAS  PubMed  Google Scholar 

  29. Birkett A, Muir J, Phillips J, et al. Resistant starch lowers fecal concentrations of ammonia and phenols in humans. Am J Clin Nutr. 1996;63(5):766–72.

    CAS  PubMed  Google Scholar 

  30. Bingham SA. Meat, starch, and nonstarch polysaccharides and large bowel cancer. Am J Clin Nutr. 1988;48:762–7.

    CAS  PubMed  Google Scholar 

  31. Blackburn GL, Wang KA. Dietary fat reduction and breast cancer outcome: results from the Women’s Intervention Nutrition Study (WINS). Am J Clin Nutr. 2007;86(3):878–81.

    Google Scholar 

  32. Block K. Alternative and complementary therapies. New York: Bantam Books; 2012.

    Google Scholar 

  33. Boggs DA, Palmer JR, Wise LA, et al. Fruit and vegetable intake in relation to risk of breast cancer in the black women’s health study. Am J Epidemiol. 2010;172(11):1268–79.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Bradshaw PT, Ibrahim JG, Stevens J, et al. Postdiagnosis change in body weight and survival after breast cancer diagnosis. Epidemiology. 2012;23:320–7.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Brandtzaeg P, Pabst R. Let’s go mucosal: communication on slippery grounds. Trend Immunol. 2004;25:570–7.

    Article  CAS  Google Scholar 

  36. Brasky TM, Darke AK, Song X, et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst. 2013;105(15):1132–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Bravi F, Bosetti C, Tavani A, et al. Coffee reduces the risk for hepatocellular carcinoma: an updated meta-analysis. Clin Gastro Hepatol. 2013;11:1413–21.

    Article  CAS  Google Scholar 

  38. Buitrago-Lopez A, Jean Sanderson J, Laura Johnson J et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011;343:d4488.

    Google Scholar 

  39. Cai S, Li Y, Ding Y, et al. Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. Eur J Cancer Prev. 2014;23(6):532–9.

    Article  CAS  PubMed  Google Scholar 

  40. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–38.

    Article  PubMed  Google Scholar 

  41. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579–91.

    Article  CAS  PubMed  Google Scholar 

  42. Campbell TC, Campbell TM. The China Study. South Australia: Wakefield Press, 2007.

    Google Scholar 

  43. Cancer Council of Australia. National Cancer Control Policy. Position statement-salt and cancer risk. Updated 2013. Available at http://wiki.cancer.org.au/policy/Position_statement_-_Salt_and_cancer_risk#cite_note-Citation:National_Heart_Foundation_of_Australia_2006-3. Accessed 5 Aug 2016.

  44. Cantor KP, Lynch CF, Hildesheim ME, et al. Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. Am J Epidemiol. 1999;150:552–60.

    Article  CAS  PubMed  Google Scholar 

  45. Capei R, Pettini A, Nostro AL, Pesavento G. Occurrence of acrylamide in breakfast cereals and biscuits available in Italy. Prev Med Hyg. 2015;56(4):E190–5.

    Google Scholar 

  46. Carroll KK, Braden LM. Dietary fat and mammary carcinogenesis. Nutr Cancer. 1985;6:254–9.

    Article  Google Scholar 

  47. Carroll KK, Braden LM, Bell JA, et al. Fat and cancer. Cancer. 1986;58:1818–25.

    Article  CAS  PubMed  Google Scholar 

  48. Cassidy A, Bingham SA, Cummings JH. Starch intake and colorectal cancer risk: an international comparison. Br J Cancer. 1994;69:937–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Chan JM, Giovannucci EL. Dairy products, calcium, and vitamin d and risk of prostate cancer. Epidemiol Revs. 2001;23:87–92.

    Article  CAS  Google Scholar 

  50. Chan JM, Stampfer MJ, Ma J, et al. Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced stage prostate cancer. J Natl Cancer Inst. 2002;94:1099–109.

    Article  CAS  PubMed  Google Scholar 

  51. Chlebowski RT, Pettinger M, Stefanick ML, et al. Insulin, physical activity, and caloric intake in postmenopausal women: breast cancer implications. J Clin Oncol. 2004;22:4507–13.

    Article  PubMed  Google Scholar 

  52. Chlebowski RT, Blackburn GL, Thomson CA, et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the women’s intervention nutrition study. J Natl Cancer Inst. 2006;98(24):1767–76.

    Article  PubMed  Google Scholar 

  53. Chen G-C, Tong X, Xu J-Y, et al. Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies. AJCN. 2016. doi:10.3945/ajcn.115.122432.

    Google Scholar 

  54. Choi Y, Park SK, Ahn K, et al. Being overweight or obese increases the risk of progression in triple-negative breast cancer after surgical resection. J Korean Med Sci. 2016;31:886–91.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Christofferson T. Tripping over the truth. The return of the metabolic theory of cancer illuminates a new and hopeful path to a cure. South Carolina: Createspace Independent Publishing Platform, 2014.

    Google Scholar 

  56. Cockbain AJ, Toogood GJ, Hull MA. Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer. Gut 2010.233718.

    Google Scholar 

  57. Coffee and Health Organisation. Available at http://coffeeandhealth.org/topic-overview/cancer/. Accessed 20 July 2016.

  58. Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst. 2000;92(1):61–8.

    Article  CAS  PubMed  Google Scholar 

  59. Colditz GA. Epidemiology of breast cancer findings from the nurses’ health study. Cancer. 1993;71:1480–9.

    Article  CAS  PubMed  Google Scholar 

  60. Comba A, Lin Y-L, Eynard AR, et al. Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. Cancer Metastasis Rev. 2011;30(3–4):325–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Connett P, Beck J, Micklem HS. The Case against fluoride. Vermont: Chelsea Green Publishing; 2010.

    Google Scholar 

  62. Connor J. Alcohol consumption as a cause of cancer. Addiction 2016 [published online] doi:10.1111/add.13477.

  63. Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. J Am Coll Nutr 2015:1–10.

    Google Scholar 

  64. D’Eliseo D, Velotti F. Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy. J Clin Med. 2016;5(2):15.

    Article  PubMed Central  Google Scholar 

  65. DebMandal M, Mandal S. Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention. Asian Pac J Trop Med. 2011;4(3):241–7.

    Article  PubMed  Google Scholar 

  66. de Jesus Raposo MF, de Morais ACMB, RMSC de Morais. Emergent sources of prebiotics: seaweeds and microalgae. Mar Drugs. 2016;14(2):27. doi:10.3390/md14020027.

  67. de Lima PL, Delmanto RD, Sugui MM, et al. Letinula edodes (Berk.) Pegler (Shiitake) modulates genotoxic and mutagenic effects induced by alkylating agents in vivo. Mutat Res. 2001;496(1–2):23–32.

    Article  PubMed  Google Scholar 

  68. de LeBlanc ADM, Matar C, Farnworth E, Perdigon G. Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir. Cytokine. 2006;34:1–8.

    Google Scholar 

  69. de LeBlanc ADM, Matar C, Perdigon G. The application of probiotics in cancer. Brit J Nutr. 2007a;98(Suppl 1): S105–10.

    Google Scholar 

  70. de LeBlanc ADM, Matar C, Farnworth E, Perdigon G. Study of immune cells involved in the antitumour effect of kefir in a murine breast cancer model. J Diary Sci. 2007b;90:1920–8.

    Google Scholar 

  71. de Vendômois JS, Roullier F, Cellier D, Séralini GE. A comparison of the effects of three GM corn varieties on mammalian health. Int J Biol Sci. 2009;10;5(7):706–26.

    Google Scholar 

  72. de Vendômois JS, Cellier D, Velo C, et al. Debate on GMOs health risks after statistical findings in regulatory tests. Int J Biol Sci. 2010;6(6):590–8.

    Article  PubMed  PubMed Central  Google Scholar 

  73. DHA/EPA Omega 3 Institute. Dietary sources of omega-3 fatty acids. 2015 http://www.dhaomega3.org/Overview/Dietary-Sources-of-Omega-3-Fatty-Acids. Accessed 30 Aug 2016.

  74. Di Nicolantonio JJ, McCarty MF, Chetterjee S, et al. A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. Nutr Cancer. 2014;66(8):1279–84.

    Article  CAS  Google Scholar 

  75. Divisi D, Di Tommaso S, Salvemini S, et al. Diet and cancer. Acta Biomed. 2006;77:118–23.

    PubMed  Google Scholar 

  76. Dong J, Zou J, Yu X-F. Coffee drinking and pancreatic cancer risk: a meta-analysis. World J Gastroenterol. 2011;17(9):1204–10.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Dong J-Y, He K, Wang P, Qin L-Q. Dietary fibre intake and risk of breast cancer: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011;94(3):900–5.

    Article  CAS  PubMed  Google Scholar 

  78. Dorenkott MR, Griffin LE, Goodrich KM, et al. Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding. J Agric Food Chem. 2014;62(10):2216–27.

    Article  CAS  PubMed  Google Scholar 

  79. Dr Axe. Stop using canola oil immediately. Food is medicine website. Available at https://draxe.com/canola-oil-gm/. Accessed 23 Aug 2016.

  80. Dr Axe. 7 reasons to get prebiotics in your diet—plus best sources. Food is medicine website. Available at https://draxe.com/prebiotics/. Accessed 30 Jan 2017.

  81. Doyle TJ, Zheng W, Cerhan JR, et al. The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. Am J Public Health. 1997;87(7):1168–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Eliassen AH, Hendickson SJ, Brinton LA, et al. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. JNCI. 2012;104(24):1905–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Elmets CA, Singh D, Tubesing K, et al. Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol. 2001;44(3):425–32.

    Article  CAS  PubMed  Google Scholar 

  84. European Food and Safety Authority. Scientific opinion on the safety of caffeine. Panel on dietetic products, nutrition and allergies (NDA). EFSA J. 2015;13(5):4102.

    Google Scholar 

  85. Environmental Working Group. EWG’s shoppers guide to pesticides in produce. Dirty Dozen. https://www.ewg.org/foodnews/dirty_dozen_list.php. Accessed 8 Aug 2016.

  86. Environmental Working Group. EWG’s shoppers guide to pesticides in produce. Clean Fifteen. https://www.ewg.org/foodnews/clean_fifteen_list.php. Accessed 8 Aug 2016.

  87. Esposito K, Chiodini P, Colao A, et al. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(1):2402–11.

    Article  PubMed  PubMed Central  Google Scholar 

  88. European Food Safety Authority. EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on acrylamide in food. J EFSA. 2015;13:4104–321. Available at http://www.efsa.europa.eu/en/efsajournal/pub/4104. Accessed 30 Aug 2016.

  89. Fabian CJ, Kimler BF, Hurstin SD. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015;17:62. doi:10.1186/s13058-015-0571-6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  90. Farvin MS, Eliassen AH, Cho E, et al. Dietary fibre intake in young adults and breast cancer risk. Pediatrics. 2016;137(3):e20151226.

    Article  Google Scholar 

  91. Fedirko V, Tramacere I, Bagnardi V, et al. Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. Ann Oncol. 2011;22(9):1958–72.

    Article  CAS  PubMed  Google Scholar 

  92. Ferguson LR, Harris PJ. Protection against cancer by wheat bran: role of dietary fibre and phytochemicals. Eur J Cancer Prev. 1999;8:17–25.

    Article  CAS  PubMed  Google Scholar 

  93. Ferguson LR, Tasman-Jones C, Englyst H, Harris PJ. Comparative effects of three resistant starch preparations on transit time and short-chain fatty acid production in rats. Nutr Cancer. 2000;36(2):230–7.

    Article  CAS  PubMed  Google Scholar 

  94. Fezai M, Senovilla L, Jemaa M, Ben-Attia M. Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil. J Lipids. 2013;Article ID 129736. doi:10.1155/2013/129736.

  95. Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr. 2000;72(4):1047–52.

    CAS  PubMed  Google Scholar 

  96. Flider FJ. GLA: uses and new sources. Inform. 2005;16(5):279–82.

    Google Scholar 

  97. Fluoridation.Com http://www.fluoridation.com/c-country.htm. Accessed 30 Jan 2017.

  98. Franceschi S, Dal Maso L, Augustin L, et al. Dietary glycemic load and colorectal cancer risk. Ann Oncol. 2001;12:173–8.

    Article  CAS  PubMed  Google Scholar 

  99. Freedman ND, Everhart JE, Lindsay KL, et al. Intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology. 2009;50(5):1360–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Freedman ND, Schatzkin A, Leitzmann MF, et al. Alcohol and head and neck cancer risk in a prospective study. J Cancer. 2007;96(9):1469–74.

    CAS  Google Scholar 

  101. Friedman M. Chemistry, biochemistry, and safety of acrylamide. A review. J Agr Food Chem. 2003;51(16):4504–26.

    Google Scholar 

  102. Fraser G. Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-hispanic white California seventh-day adventists 1,2,3. Am J Clin Nutr. 1999;70(3):532S–8S.

    CAS  PubMed  Google Scholar 

  103. Fowler JH, Christakis NA. Dynamic spread of happiness in a large social network: longitudinal analysis over 20 years in the framingham heart study. BMJ. 2008;337:a2338.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Fung TT, Hu FB, Holmes MD, et al. Dietary patterns and the risk of postmenopausal breast cancer. Int J Cancer. 2005;116:116–21.

    Article  CAS  PubMed  Google Scholar 

  105. Galeone C, Turati F, La Vecchia C, Tavani A. Coffee consumption and risk of colorectal cancer: a meta-analysis of case–control studies. Cancer Causes Control. 2010;21:1949–59.

    Article  PubMed  Google Scholar 

  106. Gibson GR, Probert HM, Loo JV, et al. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev. 2004;17:259–75.

    Article  CAS  PubMed  Google Scholar 

  107. Giovannucci E. Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis. Cancer Causes Control. 1998;9(6):567–82.

    Article  CAS  PubMed  Google Scholar 

  108. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst. 1999;91(4):317–31.

    Article  CAS  PubMed  Google Scholar 

  109. Goodwin PJ, Ennis M, Pritchard KI, et al. Fasting insulin and outcome in early-stage breast cancer: Results of a prospective cohort study. J Clin Oncol. 2002;20:42–51.

    Article  CAS  PubMed  Google Scholar 

  110. Gray UE, Pike C, Henderson BE. Breast cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practices. Br J Cancer. 1979;39(1):1–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Hakim IA, Harris RB, Brown S, et al. Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J Nutr. 2003;133(10):3303S–9S.

    CAS  PubMed  Google Scholar 

  112. Halpern M. Flax seed oil or fish oil? The best source of Omega 3s. http://breakingmuscle.com/supplements/flax-seed-oil-or-fish-oil-the-best-source-of-omega-3s. No year cited on website. Accessed 30 Aug 2016.

  113. Hamajima N, Hirose K, Tajima K, et al. Alcohol, tobacco and breast cancer–collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Brit J Cancer. 2002;87(11):1234–45.

    Article  CAS  PubMed  Google Scholar 

  114. Han X, Zheng T, Foss FM, et al. Alcohol consumption and non-Hodgkin lymphoma survival. J Cancer Surviv. 2010;4(2):101–9.

    Article  PubMed  Google Scholar 

  115. Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diab Obes 2012;19(2):81–7.

    Google Scholar 

  116. Hassan MM, Bondy ML, Wolff RA, et al. Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol. 2007;102:2696–707.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Henning SM, Niu Y, Lee NH, et al. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr. 2004;80(6):1558–64.

    CAS  PubMed  Google Scholar 

  118. Hogervorst JG, Schouten LJ, Konings EJ, et al. A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Cancer Epidem Biomark Prev. 2007;16(11):2304–13.

    Article  CAS  Google Scholar 

  119. Hogervorst JG, Schouten LJ, Konings EJ, et al. Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr. 2008;87(5):1428–38.

    CAS  PubMed  Google Scholar 

  120. Houmard JA, Tanner CJ, Yu C, et al. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. Diab Care. 2002;51:2959–63.

    Article  CAS  Google Scholar 

  121. Howe GR, Benito E, Castelleto R, et al. Dietary intake of fibre and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J Natl Cancer Inst. 1992;84(24):1887–96.

    Article  CAS  PubMed  Google Scholar 

  122. Hirayama T. Epidemiology of breast cancer with special reference to the role of diet. Prev Med. 1978;7(2):173–95.

    Article  CAS  PubMed  Google Scholar 

  123. Holm M, Olsen A, Christensen J, et al. Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake. Int J Cancer. 2013;132(3):686–94.

    Article  CAS  PubMed  Google Scholar 

  124. Hrudy SE, Backer LC, Humpage AR, et al. Evaluating evidence for association of human bladder cancer with drinking-water chlorination disinfection by-products. J Toxicol Environ Health B Crit Rev. 2015;18(5):213–41.

    Article  CAS  Google Scholar 

  125. Hu J-Y, Hu Y-W, Zhou J-J, et al. Consumption of garlic and risk of colorectal cancer: an updated meta-analysis of prospective studies. World J Gastroenterol. 2014;20(41):15413–22.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Ibrahim YH, Yee D. Insulin-like growth factor-I and cancer risk. Growth Hormon IGF Res. 2004;14(4):261–9.

    Article  CAS  Google Scholar 

  127. International Agency for Research on Cancer. IARC Monographs evaluate consumption of red meat and processed meat. Press Release No. 240, 2015. Available at https://www.iarc.fr/en/media-centre/pr/2015/pdfs/pr240_E.pdf. Accessed 2 Aug 2016.

  128. International Food Information Foundation Council. Functional Foods Fact Sheet: Probiotics and Prebiotics 2014. Available at http://www.foodinsight.org/Functional_Foods_Fact_Sheet_Probiotics_and_Prebiotics. Accessed 1 Feb 2017.

  129. Irwin ML, Duggan C, Smith A et al. Fasting C-peptide levels and death due to all causes and breast cancer: the health eating activity and lifestyle (HEAL) Study. Presented at the AACR Frontiers in Cancer Prevention Conference, National Harbor, MD. 2008 Nov:16–19. In McTiernan A, Irwin M, VonGruenigen V. Weight, physical activity, diet, and prognosis in breast and gynecologic cancers. J Clin Oncol. 2010;28(26):4074–80.

    Google Scholar 

  130. Irwin M. Weight loss interventions and breast cancer survival: the time is now. JCO. 2014;32(21):2197–9.

    Article  Google Scholar 

  131. Ishikawa H, Saeki T, Otani T, et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr. 2006;136:816S–20S.

    CAS  PubMed  Google Scholar 

  132. Islami F, Boffetta P, Ren JS, et al. High-temperature beverages and foods and oesophageal cancer risk-A systematic review. Int J Cancer. 2009;125:491–524.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Israilides C, Kletsas D, Arapoglou D, et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Phytomedicine. 2008;15(6–7):512–9.

    Article  CAS  PubMed  Google Scholar 

  134. Jiang W, Wu Y, Jiang X. Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol Oncol. 2013;129(3):620–9.

    Article  CAS  PubMed  Google Scholar 

  135. Jin X, Ruiz Beguerie J, Sze DM, Chan GCF. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016;4:Art. No: CD007731. doi:10.1002/14651858.CD007731.pub3.

  136. Jing K, Wu T, Lim K. Omega-3 polyunsaturated fatty acids and cancer. Anticancer Agents Med Chem. 2013;13(8):1162–77.

    Article  CAS  PubMed  Google Scholar 

  137. Jiralerspong S, Kim ES, Dong W et al. Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients. Ann Oncol. 2013;24:250614.

    Google Scholar 

  138. Jourdain C, Tenca G, Deguercy A, et al. In-vitro effects of polyphenols from cocoa and [beta]-sitosterol on the growth of human prostate cancer and normal cells. Eur J Cancer Prev. 2006;15(4):353–61.

    Article  CAS  PubMed  Google Scholar 

  139. Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control. 1996;7(6):605–25.

    Article  CAS  PubMed  Google Scholar 

  140. Kaga C, Tagak A, Kano M, et al. Lactobacillus caei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer. Cancer Sci. 2013;104:1508–14.

    Article  CAS  PubMed  Google Scholar 

  141. Keeler GJ, Landis MS, Norris GA, et al. Sources of mercury wet deposition in Eastern Ohio, USA. Environ Sci Technol. 2006;40:5874–81.

    Article  CAS  PubMed  Google Scholar 

  142. Key J, Hodgson S, Omar RZ, et al. Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes Control. 2006;17(6):759–70.

    Article  PubMed  Google Scholar 

  143. Kiecolt-Glaser JK, Belury MA, Andridge R, et al. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011;25(8):1725–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Kim J-E, Song D, Kim J, et al. Oral supplementation with cocoa extract reduces UVB-induced wrinkles in hairless mouse skin. J Invest Dermatol. 2016;136(5):1012–21.

    Article  CAS  PubMed  Google Scholar 

  145. Kiyabu GY, Inoue M, Saito E, et al. Fish, n − 3 polyunsaturated fatty acids and n − 6 polyunsaturated fatty acids intake and breast cancer risk: the Japan public health center-based prospective study. Int J Cancer. 2015;137(12):2915–26.

    Article  CAS  PubMed  Google Scholar 

  146. Kok J, Kromhout D. Atherosclerosis: epidemiological studies on the health effects of a Mediterranean diet. Eur J Nutr. 2004;43(1):I/2–I/5.

    Google Scholar 

  147. Kneller RW, Guo W, Hsing AW, et al. Risk factors for stomach cancer in sixty-five Chinese counties. Cancer Epi Biomar Prev. 1992;1(2):113–8.

    CAS  Google Scholar 

  148. Koushik A, Hunter DJ, Spiegelman D, et al. Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies. J Natl Cancer Inst. 2007;99(19):1471–83.

    Article  PubMed  Google Scholar 

  149. Kucuk O, Sarkar FH, Sakr W, et al. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomar Prev. 2001;10(8):861–8.

    CAS  Google Scholar 

  150. Kumar M, Verma V, Nagpal R, et al. Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB1-induced hepatocellular carcinoma. Gene. 2011;490:54–9.

    Article  CAS  PubMed  Google Scholar 

  151. Kumar M, Kumar A, Nagpal R, et al. Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr. 2010;61(5):473–96.

    Article  CAS  PubMed  Google Scholar 

  152. Kwan ML, Chen WY, Flatt SW et al. Postdiagnosis alcohol consumption and breast cancer prognosis in the After Breast Cancer Pooling Project. Cancer Epidemiology Biomarkers and Prevention 2013;22(1):32–41

    Google Scholar 

  153. Kwan ML, Weltzien E, Kushi LH, et al. Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer. J Clin Oncol. 2009;27(6):919–26.

    Article  PubMed  Google Scholar 

  154. Lakritz JR, Poutahidis T, Levkovich T, et al. Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int J Cancer. 2014;135:529–40.

    Article  CAS  PubMed  Google Scholar 

  155. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. J Nutr. 2003;133(10):3262S–7S.

    CAS  PubMed  Google Scholar 

  156. Landon S, Colyer CGB, Salman H. The resistant starch report. An Australian update on the health benefits, measurement and dietary intakes. Food Australia supplement. 2012. Available at http://foodaust.com.au/wp-content/uploads/2012/04/Hi_Maize-supplement_web.pdf. Accessed 2 Oct 2016.

  157. Lazarevik K, Nagorni A, Jeremic M. Carbohydrate intake, glycemic index, glycemic load and risk of gastric cancer. Cent Eur J Public Health. 2009;17(2):75–8.

    Google Scholar 

  158. Lee L. Fluoride—a modern toxic waste. 2005. Available at http://www.litalee.com/documents/Fluoride-AModernToxicWaste.pdf. Accessed 20 Sept 2016.

  159. Leung WW, Ho SC, Chan HLY et al. Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study. J Epidemiol Community Health 2011;65:556e558.

    Google Scholar 

  160. Li G, Ma D, Zhang Y, et al. Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies. Public Health Nutr. 2012;16(2):346–57.

    Article  PubMed  Google Scholar 

  161. Li J, Seibold P, Chang-Claude J, et al. Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Res. 2011;13:R49.

    Article  PubMed  PubMed Central  Google Scholar 

  162. Li Y, Zhang T. Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncol. 2013;9(8):1097–103.

    Article  CAS  PubMed  Google Scholar 

  163. Li XJ, Ren ZJ, Qin JW, et al. Coffee consumption and risk of breast cancer: an up to date meta-analysis. PLoS ONE. 2013;8(1):e52681.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  164. Lin P-W, Aronson W, Feedland SJ. Nutrition, dietary interventions and prostate cancer: the latest evidence. BMC Med. 2015;13:3. Published online 2015 Jan 8. doi:10.1186/s12916-014-0234-y.

  165. Linnewiel-Hermoni K, Khanin M, Danilenko M, et al. The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity. Arch Biochem Biophys. 2015;572:28–35.

    Article  CAS  PubMed  Google Scholar 

  166. Loomis D, Guyton KZ, Grosse Y, et al. Carcinogenicity of drinking coffee, mate and very hot beverages. Lancet 2016;17:877–8.

    Google Scholar 

  167. Lopez-Garcia E, Schulze MB, Meigs JB, et al. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr. 2005;135(3):562–6.

    CAS  PubMed  Google Scholar 

  168. Luo H, Tang L, Tang M, et al. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis. 2006;27(2):262–8.

    Article  CAS  PubMed  Google Scholar 

  169. MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, et al. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006;295(4):403–15.

    Article  CAS  PubMed  Google Scholar 

  170. Martinez VD, Vuvic EA, Becker-Santos DD et al. Arsenic exposure and the induction of human cancers. J Toxicol. 2015; 2011, 13 pages. Article ID 431287. doi:10.1155/2011/431287.

  171. McDonald JA, Goyal A, Terry MB. Alcohol intake and breast cancer risk: weighing the overall evidence. Curr Breast Cancer Rep. 2013;5(3). doi:10.1007/s12609-013-0114-z.

  172. McGeehin MA, Reif JS, Becher JC, Mangione EJ. Case-control study of bladder cancer and water disinfection methods in Colorado. Am J Epidemiol. 1993;138(7):492–501.

    Article  CAS  PubMed  Google Scholar 

  173. McTiernan A, Rajan KB, Tworoger SS, et al. Adiposity and sex hormones in postmenopausal breast cancer survivors. J Clin Oncol. 2003;21(10):1961–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  174. Mercola J. The science is practically screaming… Don’t make this trendy fat mistake 2011. http://articles.mercola.com/sites/articles/archive/2011/11/11/everything-you-need-to-know-about-fatty-acids.aspx.

  175. Messina MJ, Persky V, Setchell KD, Barnes S. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer. 1994;21:113–31.

    Article  CAS  PubMed  Google Scholar 

  176. Michaud DS, Gallo V, Schiehofer B, et al. Coffee and tea intake and risk of brain tumors in the European prospective investigation into cancer and nutrition (EPIC) cohort study. Am J Clin Nutr. 2010;92:1145–50.

    Article  CAS  PubMed  Google Scholar 

  177. Missmer SA, Smith-Warner SA, Spiegelman D, et al. Meat and dairy consumption and breast cancer: a pooled analysis. Int J Epidemiol. 2002;31:78–85.

    Article  PubMed  Google Scholar 

  178. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors. JAMA. 2003;289(1):76–9.

    Article  PubMed  Google Scholar 

  179. Moss J, Davies T, Garaiova I et al. A unique combination of nutritionally active ingredients can prevent several key processes associated with atherosclerosis in vitro. Published: March 7, 2016 Plos 1. doi:10.1371/journal.pone.0151057. Accessed 8 Aug 2016.

  180. Nagle CM, Purdie DM, Webb PM, et al. Dietary influences on survival after ovarian cancer. Int J Cancer. 2003;106(2):264–9.

    Article  CAS  PubMed  Google Scholar 

  181. National Cancer Institute. Acrylamide in food and cancer risk. 2008 http://www.cancer.gov/about-cancer/causes-prevention/risk/diet/acrylamide-fact-sheet. Accessed 30 Aug 2016.

  182. National Cancer Institute Obesity and Cancer Risk Fact Sheet. Updated 2012. Available at http://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet. Accessed 30 May 2016.

  183. National Cancer Institute. Tea and Cancer Prevention. Available at https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/tea-fact-sheet.

  184. National Institute of Health. National Heart, Lung and Blood Institute. What are the health risks of overweight and obesity? 2012. https://www.nhlbi.nih.gov/health/health-topics/topics/obe/risks. Accessed 8 Aug 2016.

  185. National Toxicology Program. NTP Technical report on the toxicology and carcinogenesis studies of Sodium Flo = uoride (CAS no. 7682-49-4) in F344/N Rats and B6C3F1 (Drinking Water Studies). Technical Report 393, NIH pulic no. 91-2848, National Institutes of Health, Public health Service, US Department of Health and Human Services, NC, 1990. In Connett P, Beck J, Micklem HS. The Case Against Fluoride. Chapter 18 Fluoride and Osteosarcoma. Vermont: Chelsea Green Publishing, 2010.

    Google Scholar 

  186. Newcomb PA, Kampman E, Trentham-Dietz A, et al. Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes. J Clin Oncol. 2013;31(16):1939–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  187. Ngo SN, Williams DB, Cobiac L, Head RJ. Does garlic reduce risk of colorectal cancer? A Syst Rev J Nutr. 2007;137(10):2264–9.

    CAS  Google Scholar 

  188. Nkondjock A, Ghadirian P, Kotsopoulos J, et al. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Int J Cancer. 2006;118:103–7.

    Article  CAS  PubMed  Google Scholar 

  189. Norat T, Bingham S, Ferrari P, et al. Meat, fish, and colorectal cancer risk: the European prospective investigation into cancer and nutrition. J Natl Cancer Inst. 2005;97(12):906–16.

    Article  PubMed  PubMed Central  Google Scholar 

  190. O’Keefe SH, Li JV, Lahti L et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun. 2015;6:6342. doi:10.1038/ncomms7342.

  191. Okuno K, Uno K. Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 2011;12(7):1671–4.

    PubMed  Google Scholar 

  192. Olesen PT, Olsen A, Frandsen H, et al. Acrylamide exposure and incidence of breast cancer among postmenopausal women in the Danish diet, cancer and health study. Int J Cancer. 2008;122:2094–100.

    Article  CAS  PubMed  Google Scholar 

  193. Olive Oil Source. http://www.oliveoilsource.com/. Accessed 20 Aug 2016.

  194. Orlich MJ, Singh PN, Sabaté J, et al. Vegetarian dietary patterns and mortality in adventist health study 2. JAMA Intern Med. 2013;173(13):1230–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. Otokazawa S, Tanaka R, Akasaka H, et al. Associations of serum isoflavone, adiponectin and insulin levels with risk for epithelial ovarian cancer: results of a case-control study. Asian Pac J Cancer Prev. 2015;16(12):4987–91.

    Article  Google Scholar 

  196. Owen RW, Giacosa A, Hull WE, et al. Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol. 2000;1:107–12.

    Article  CAS  PubMed  Google Scholar 

  197. Pal S, Woodford K, Kukuljan S, Ho S. Milk intolerance, beta-casein and lactose. Nutrients. 2015;7:7285–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  198. Park Y, Brinton LA, Subar AF et al. Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health–AARP Diet and Health Study. Am J Clin Nutr. 2009;90(3):664–71.

    Google Scholar 

  199. Patel S, Goyal A. Recent developments in mushrooms as anti-cancer therapeutics: a review. Biotech. 2012;2(1):1–15.

    Google Scholar 

  200. Patel S, Goyal A. Evolving roles of probiotics in cancer prophylaxis and therapy. Probiotics Antimicro Prot. 2013;5:59. doi:10.1007/s12602-012-9124-9.

    Article  Google Scholar 

  201. Pelucchi C, Bosetti C, Negri E, et al. Olive oil and cancer risk: an update of epidemiological findings through 2010. Curr Pharm Des. 2011;17(8):805–12.

    Article  CAS  PubMed  Google Scholar 

  202. Perdigon G, Bonet B, de Jorrat ME, et al. Antitumor activity of orally administered L. casei significance of its dose in the inhibition of a fibrosarcoma in mice. Food Agric Immunol. 1993;5:39–49.

    Article  CAS  Google Scholar 

  203. Physicians Committee for Responsible Medicine. Section two cancer prevention. Available at http://www.pcrm.org/health/healthcare-professionals/nutrition-curriculum/section-two-cancer-prevention. Accessed 25 Jan 2017.

  204. Physicians Committee for Responsible Medicine, 2012. How fibre helps protect against cancer. Available at https://www.pcrm.org/health/cancer-resources/diet-cancer/nutrition/how-fibre-helps-protect-against-cancer. Accessed 23 Oct 2016.

  205. Pierce BL, Neuhouser ML, Wener MH, et al. Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors. Breast Cancer Res Treat. 2009;114(1):155–67.

    Article  CAS  PubMed  Google Scholar 

  206. Platz EA, Giovannucci E, Rimm EB, et al. Dietary fibre and distal colorectal adenoma in men. Cancer Epidemiol Biomar Prev. 1997;6:661–70.

    CAS  Google Scholar 

  207. Prediger RD. Effects of caffeine in Parkinson’s disease: from neuroprotection to the management of motor and non-motor symptoms. J Alzheimers Dis. 2010;20(Suppl 1):S205–20.

    Article  CAS  PubMed  Google Scholar 

  208. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, et al. Low-fat dietary pattern and risk of invasive breast cancer. The women’s health initiative randomized controlled dietary modification trial. JAMA. 2006;295:629–42.

    Article  CAS  PubMed  Google Scholar 

  209. Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat. 2010;123:627–35.

    Article  PubMed  Google Scholar 

  210. Ramljak D, Romanczyk LJ, Metheny-Barlow LJ, et al. Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. Mol Cancer Ther. 2005;4(4):537–46.

    Article  CAS  PubMed  Google Scholar 

  211. Rassaf T, Rammos C, Hendgen-Cotta UB. Vasculoprotective effects of dietary cocoa flavanols in patients on hemodialysis: a double–blind, randomized, placebo–controlled trial. Clin J Am Soc Nephrol. Published online Dec 2015. doi:10.2215/CJN.05560515.

  212. Reavley N, Sali A. Evaluation of the effects of a psychosocial intervention on mood, coping, and quality of life in cancer patients. Int Canc Ther. 2009;8(1):47–55.

    Article  Google Scholar 

  213. Redman MG, Ward EJ, Phillips RS. The efficacy and safety of probiotics in people with cancer: a systematic review. Ann Oncol. 2014;25(10):1919–29.

    Article  CAS  PubMed  Google Scholar 

  214. Rennie KL, Hughes J, Lang R, Jebb SA. Nutritional management of rheumatoid arthritis: a review of the evidence. J Hum Nutr Dietet. 2003;16:97–109.

    Article  CAS  Google Scholar 

  215. Ridlon JM, Hylemon PB. A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk. Cancer Biol Ther. 2006;5(3):273–4.

    Google Scholar 

  216. Ried K, Travica N, Sali A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at heart trial. Integr Blood Press Control. 2016;9:9–21.

    Article  PubMed  PubMed Central  Google Scholar 

  217. Rock CL, Demark-Wahnefried W. Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J Clin Oncol. 2002;20(15):3302–16.

    Article  PubMed  PubMed Central  Google Scholar 

  218. Rock CL, Flatt SW, Natarajan L, et al. Plasma carotenoids and recurrence-free survival in women with a history of breast cancer. J Clin Oncol. 2005;23(27):6631–8.

    Article  CAS  PubMed  Google Scholar 

  219. Rock CL, Flatt SW, Thomson CA, et al. Effects of a high-fibre, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. J Clin Oncol. 2004;22(12):2379–87.

    Article  CAS  PubMed  Google Scholar 

  220. Rose DP, Boyar AP, Wynder EL. International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer. 1986;58:2363–71.

    Article  CAS  PubMed  Google Scholar 

  221. Ruiz-Canela M, Martínez-González MA. Olive oil in the primary prevention of cardiovascular disease. Maturitas. 2011;68(3):245–50.

    Article  CAS  PubMed  Google Scholar 

  222. Sackett DK, Aday DD, Rice JA, et al. Does proximity to coal-fired power plants influence fish tissue mercury? Ecotoxicology. 2010;19:1601. doi:10.1007/s10646-010-0545-5.

    Article  CAS  PubMed  Google Scholar 

  223. Saladi RN, Nektalova T, Fox JL. Induction of skin carcinogenicity by alcohol and ultraviolet light. Clin Exp Dermatol. 2010;35:7–11.

    Article  CAS  PubMed  Google Scholar 

  224. Sang LX. Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol. 2013;13:34.

    Article  PubMed  PubMed Central  Google Scholar 

  225. Sansbury LB, Wanke K, Albert PS, et al. The effect of strict adherence to a high-fibre, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence. Am J Epidemiol. 2009;170:576–84.

    Article  PubMed  PubMed Central  Google Scholar 

  226. Schafer G, Kaschula CH. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anticancer Agents Med Chem. 2014;14(2):233–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  227. Schinasi L, Leon ME. Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. Int J Environ Res Public Health. 2014;11(4):4449–527.

    Article  PubMed  PubMed Central  Google Scholar 

  228. Schmit S, Rennert HS, Rennert G, Gruber SB. Coffee consumption and the risk of colorectal cancer. Canc Epidemiol Biomar Prev. 2016;25:634.

    Article  CAS  Google Scholar 

  229. Seralini G-E, Mesnage R, Defarge N, de Vendomois JS. Biosafety and the ‘Seralini affair’—scientific and regulatory reform are essential. Ecologist 2014. Available at http://www.theecologist.org/blogs_and_comments/commentators/2452325/biosafety_and_the_seralini_affair_scientific_and_regulatory_reform_are_essential.html.

  230. Sesso HD, Buring JE, Zhang SM, et al. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiol Biomar Prev. 2005;14(5):1074–81.

    Article  CAS  Google Scholar 

  231. Sesso HD, Paffenbarger RS, Lee I-M. Alcohol consumption and risk of prostate cancer: the Harvard Alumni health study. Int J Epidemiol. 2001;30(4):749–55.

    Article  CAS  PubMed  Google Scholar 

  232. Seyfried TN, Flores RE, D’Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014;35(3):515–27.

    Article  CAS  PubMed  Google Scholar 

  233. Seyfried TN. Cancer as a metabolic disease. New Jersey: Wiley; 2012.

    Book  Google Scholar 

  234. Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54:438–63.

    CAS  PubMed  Google Scholar 

  235. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002;56(8):365–79.

    Article  CAS  PubMed  Google Scholar 

  236. Simopoulos AP. Evolutionary aspects of diet: the Omega-6/Omega-3 ratio and the brain. Mol Neurobiol. 2011;44:203. doi:10.1007/s12035-101-8162-0.

    Article  CAS  PubMed  Google Scholar 

  237. Sivan A, Corrales L, Hubert N, et al. Commensal bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015;350(6264):1084–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  238. Soler M, Bosetti C, Franceschi S, et al. Fibre intake and the risk of oral, pharyngeal and oesophageal cancer. Int J Cancer. 2001;91:283–7.

    Article  CAS  PubMed  Google Scholar 

  239. Song M, Zhang X, Meyerhardt JA et al. Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis. Gut 2016. pii: gutjnl-2016-311990. doi:10.1136/gutjnl-2016-311990.

  240. Steele VE, Kelloff GJ, Balentine D, et al. Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays. Carcinogenesis. 2000;21(1):63–7.

    Article  CAS  PubMed  Google Scholar 

  241. Steinmetz KA, Kushi LH, Bostick RM, et al. Vegetables, fruit, and colon cancer in the lowa women’s health study. Am J Epidemiol. 1994;139(1):1–15.

    Article  CAS  PubMed  Google Scholar 

  242. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996;96:1027–39.

    Article  CAS  PubMed  Google Scholar 

  243. Stoll BA. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr. 1999;53(2):83–7.

    Article  CAS  PubMed  Google Scholar 

  244. Stoner GD. Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res. 2009;2(3):187–94.

    Article  CAS  Google Scholar 

  245. Tanaka T, Shnimizu M, Moriwaki H. Cancer chemoprevention by carotenoids. Molecules. 2012;17:3202–42.

    Article  CAS  PubMed  Google Scholar 

  246. Tang N, Zhou B, Wang B, Yu R. Coffee consumption and risk of breast cancer: a meta-analysis. Am J Obstet Gynecol. 2009;200:290.e1-9.

    Google Scholar 

  247. Tang L, Zhang Y, Jobson HE, et al. Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Molecular Cancer Ther. 2006;5(4):935–44.

    Article  CAS  Google Scholar 

  248. Taub PR, Ramirez-Sanchez I, Ciaraldi TP et al. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012;5(1):43. doi:10.1111/j.1752-8062.2011.00357.x. Accessed 30 Aug 2016.

  249. Terry P, Giovannucci E, Michels KB, et al. Fruit, vegetables, dietary fibre, and risk of colorectal cancer. JNCI J Natl Cancer Inst. 2001;93(7):525–33.

    Article  CAS  PubMed  Google Scholar 

  250. Toi M, Hirota S, Tomotaki A, et al. Probiotic beverage with soy isoflavone consumption for breast cancer prevention: a case-control study. Nutr Food Sci. 2013;9(3):194–200.

    CAS  Google Scholar 

  251. Toure A, Xueming X. Flaxseed lignans: source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits. Compr Rev Food Sci Food Saf. 2010;9(3):261–9.

    Article  CAS  Google Scholar 

  252. Trejo-Solis C, Pedraza-Chaverri J, Torres-Ramos M, et al. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid Based CAM. 2013;2013:705121.

    Google Scholar 

  253. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599–608.

    Article  PubMed  Google Scholar 

  254. Trock B, Lanza E, Greenwald P. Dietary fibre, vegetables, and colon cancer: critical review and meta-analyses of the epidemiologic evidence. J Natl Cancer Inst. 1990;82(8):650–61.

    Article  CAS  PubMed  Google Scholar 

  255. Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. JNCI. 2006;98(7):459–71.

    Article  CAS  PubMed  Google Scholar 

  256. Tuohimaa P, Tenkanen L, Ahonen M, et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer. 2004;108:104–8.

    Article  CAS  PubMed  Google Scholar 

  257. Turati F, Galeone C, La Vecchia C, et al. Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies. Ann Oncol. 2010;22(3):536–44.

    Article  PubMed  Google Scholar 

  258. UK Department of Health. UK chief medical officer’s low risk drinking guidelines. August 2016. https://www.gov.uk/government/publications/consumption-of-alcoholic-beverages-and-risk-of-cancer. Accessed 12 Jan 2017.

  259. University of Maryland Medical Centre. Omega-3 fatty acids. 2015. https://umm.edu/health/medical/altmed/supplement/omega3-fatty-acids. Accessed 10 Aug 2016.

  260. U.S. Department of Health and Human Services. Surgeon General’s Report on Nutrition and Health. DHHS Publ No. 88-50210, 1988.

    Google Scholar 

  261. Van Dam RM, Willet WC, Manson JE, Hu FB. Coffee, caffeine, and risk of type 2 diabetes. Diab Care. 2006;29(2):398–403.

    Article  Google Scholar 

  262. Vance V, Mourtzakis M, McCargar L, et al. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev. 2011;12:282–94.

    Article  CAS  PubMed  Google Scholar 

  263. Verberne K, Bach-Faig A, Buckland G, Serra-Majern L. Association between the Mediterranean diet and cancer risk: a review of observational studies. Nutr Cancer. 2010;62(7):860–70.

    Article  PubMed  Google Scholar 

  264. Verhoeven V, Renard N, Makir A, et al. Probiotics enhance the clearance of human papillomavirus-related cervical lesions: a prospective controlled pilot study. Eur J Cancer Prev. 2013;22(1):46–51.

    Article  PubMed  Google Scholar 

  265. Vigneri P, Frasca F, Sciacca L, et al. Diabetes and cancer. Endocr Relat Cancer. 2009;16(4):1103–23.

    Article  CAS  PubMed  Google Scholar 

  266. Villanueva CM, Cantor KP, Grimalt JO et al. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools Am J Epidemiol. 2007;165(2):148–56.

    Google Scholar 

  267. Vinderola CG, Duarte J, Thangavel D, et al. Immunomodulating capacity of kefir. J Dairy Res. 2005;72:195–202.

    Article  CAS  PubMed  Google Scholar 

  268. Wada M, Nagata S, Saito M, et al. Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Support Cancer Care. 2010;18(6):751–9.

    Article  Google Scholar 

  269. Walia S, Kamal R, Singh Kanwar S, Dhawan DK. Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine incuded colon carcinogenesis in rats. Nutr Cancer. 2015;67(4):603–11.

    Article  PubMed  Google Scholar 

  270. Wang J, Zhong M, Liu B, et al. Expression and functional analysis of novel molecule—Latcripin-13 domain from Lentinula edodes C91-3 produced in prokaryotic expression system. Gene. 2015;555(2):469–75.

    Article  CAS  PubMed  Google Scholar 

  271. Wang J, Varghese M, Ono K. Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer’s disease. J Alzheimer’s Dis. 2014;41(2):643–50.

    CAS  Google Scholar 

  272. Whiteman MK, Hillis SD, Curtis KM, McDonald JA, Wingo PA, Marchbanks PA. Body mass and mortality after breast cancer diagnosis. Cancer Epidemiol Biomar Prev. 2005;14:2009–14.

    Article  Google Scholar 

  273. Wilkinson D. Can food be medicine against cancer? A healthy handbook that combines science, medicine and not-so-common sense. Australia: Inspiring Publishers; 2015.

    Google Scholar 

  274. Woolley K, Fishbach A. A recipe for friendship: similar food consumption promotes trust and cooperation. J Consum Psych. 2016. doi:10.1016/j.jcps.2016.06.003.

    Google Scholar 

  275. Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr. 2001;73(suppl):451S–5S.

    CAS  PubMed  Google Scholar 

  276. World Cancer Research Fund and American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington DC: AICR; 2007.

    Google Scholar 

  277. World Health Organization. Health Implications of Acrylamide in Food. Report of a Joint FAO/WHO Consultation. WHO Headquarters, Geneva, Switzerland 25–27 June 2002. Available at http://apps.who.int/iris/bitstream/10665/42563/1/9241562188.pdf. Accessed 30 Aug 2016.

  278. World Health Organization and International Agency for Research on Cancer. Globocan 2008, Cancer Fact Sheet. Prostate Cancer Incidence, Mortality and Prevalence Worldwide in 2008 Summary. Available at: http://globocan.iarc.fr.

  279. World Health Organization and International Agency for Research on Cancer. Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx). Accessed 10 Aug 2016.

  280. Wu AH, Wan P, Hankin G, et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis. 2002;23(9):1491–6.

    Article  CAS  PubMed  Google Scholar 

  281. Wu AH, Pike MC, Stram DO. Meta-analysis: dietary fat intake, serum estrogen levels and the risk of breast cancer. J Nat Cancer Inst. 1999;91:529–34.

    Article  CAS  PubMed  Google Scholar 

  282. Wu AH, Yu MC, Tseng CC, Pike MC. Epidemiology of soy exposures and breast cancer risk. Brit J Cancer. 2008;98:9–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  283. Yiamouyiannis J, Burk D. Fluoridation and cancer-age-dependence of cancer mortality related to artificial fluoridation. Fluoride. 1997;10(3):102–23.

    Google Scholar 

  284. Yu X, Bao Z, Zou J, Dong J. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer. 2011;11:96. Available at https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-96.

  285. Yu H, Role RT. Role of insuline-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472–89.

    Article  CAS  PubMed  Google Scholar 

  286. Yukawa H, Ishikawa S, Kawanishi T, et al. Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line. Biol Pharm Bull. 2012;35(7):1014–21.

    Article  CAS  PubMed  Google Scholar 

  287. Zang J, Shen M, Du S, et al. The association between dairy intake and breast cancer in western and Asian populations: a systematic review and meta-analysis. Breast Cancer. 2015;18(4):313–22.

    Article  Google Scholar 

  288. Zaveri NT. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 2006;78(18):2073–80.

    Article  CAS  PubMed  Google Scholar 

  289. Zhang X, Spiegelman D, Baglietto L, et al. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr. 2012;95(3):713–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  290. Zhang Y, Wqang X, Cui D. Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies. Int J Exp Med. 2015;8(7):11657–65.

    Google Scholar 

  291. Zheng JS, Yang J, Fu Y-Q, et al. Effects of green tea, black tea, and coffee consumption on the risk of oesophageal cancer: a systematic review and meta-analysis of observational studies. Nutr Cancer. 2013;65(1):1–16.

    Article  CAS  PubMed  Google Scholar 

  292. Zhong L, Zhang X, Covasa M. Emerging roles of lactic acid bacteria in protection against colorectal cancer. World J Gastroenterol. 2014;20(24):7878–86.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  293. Zhou Y, Zhuang W, Hu W, et al. Consumption of large amounts of allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology. 2011;141:80–9.

    Article  CAS  PubMed  Google Scholar 

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O’Brien, K., Sali, A. (2017). Nutrition. In: A Clinician's Guide to Integrative Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-56632-0_3

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