Abstract
Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are closely linked. PLS might only affect the bulbar innervated muscle and cause spasticity. On the contrary, ALS involves both upper and lower motor neurons. A familial juvenile PLS was identified to be due to mutations in the ALS2 gene, encoding a guanine-nucleotide exchange factor for GTPase [1–5]. The gene is also called alsin, and its mutations are transmitted as autosomal recessive traits.
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References
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Angelini, C. (2018). Amyotrophic Lateral Sclerosis Type 2, Juvenile. In: Genetic Neuromuscular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-56454-8_106
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DOI: https://doi.org/10.1007/978-3-319-56454-8_106
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