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Probiotics in the Prevention of Gestational Diabetes Mellitus (GDM)

  • Luisa F. Gomez Arango
  • Helen L. Barrett
  • Leonie K. Callaway
  • H. David McIntyre
  • Marloes Dekker NitertEmail author
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

The microbiome, the composite of bacteria present on the human body, has a critical role in the regulation of metabolism, immune function, and behavior. In pregnancy, the gut microbiota is altered, becoming less diverse as pregnancy progresses. The oral, vaginal, and placental microbiotas may also be affected by pregnancy. These changes may contribute to maternal physiological changes in pregnancy. Outside pregnancy, obesity, and diabetes are associated with changes to the composition of the gut microbiota. Whether or not obesity and diabetes compound pregnancy-associated changes to the microbiome is unclear. Manipulation of the gut microbiota by probiotic supplementation may be a strategy to prevent the development of gestational diabetes mellitus. In this chapter, the pregnancy-associated changes to the microbiome and the effects of probiotic supplementation on the prevention of gestational diabetes mellitus will be discussed.

Keywords

Gestational diabetes mellitus Microbiome Metabolism Pregnancy Probiotics Prebiotics Pregnancy complications 

Abbreviations

GDM

Gestational diabetes mellitus

HOMA-B

Homeostatic model assessment of beta cell function

HOMA-IR

Homeostatic model assessment of insulin resistance

Hs-CRP

High sensitivity C-reactive protein

SCFA

Short chain fatty acids

VLDL

Very low-density lipoprotein

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Luisa F. Gomez Arango
    • 1
  • Helen L. Barrett
    • 1
  • Leonie K. Callaway
    • 2
  • H. David McIntyre
    • 3
  • Marloes Dekker Nitert
    • 1
    Email author
  1. 1.School of Medicine, The UQ Centre for Clinical ResearchThe University of QueenslandHerstonAustralia
  2. 2.Faculty of Medicine, School of Medicine, RBWH Clinical School, The UQ Centre for Clinical ResearchThe University of QueenslandHerstonAustralia
  3. 3.School of Medicine, Mater Clinical SchoolThe University of QueenslandSouth BrisbaneAustralia

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