Skip to main content

Overview of Selenium Deficiency and Toxicity Worldwide: Affected Areas, Selenium-Related Health Issues, and Case Studies

Part of the Plant Ecophysiology book series (KLEC,volume 11)

Abstract

Selenium (Se) is an essential micronutrient for human and animal healthy due to its capabilities to support antioxidant defence systems. However, problems related to the deficiency of Se are emerging issue for human health worldwide and plant species differ considerably in their susceptibility to high concentrations of Se, and certain plant species can be able to accumulate Se to astonishingly high concentrations. Many factors can affect the content of Se in different foods, including different uptake rate by plants, which can be related to plant type, soil, pH, microbial activity, rainfall and a number of other biogeochemical parameters. Humans Se intake and Se status in the population depends firstly on Se concentrations in soils, and hence the Se concentrations in the harvested edible plants in these soils. Thus, this chapter aims to compile some information about research work on essentiality of Se for humans and other mammals, and the need for a sufficient daily Se intake.

Keywords

  • Agronomic bio-fortification
  • Human health
  • Oxidative stress
  • Selenium toxicity
  • Keshan disease

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Acuña JJ, Jorquera MA, Barr PJ, Crowley DE, de la Mora M (2013) Selenobacteria selected from the rhizosphere as a potential tool for Se biofortification of wheat crops. Biol Fertil Soils 49:175–185

    CrossRef  CAS  Google Scholar 

  • Aggarwal M, Sharma S, Kaur N, Pathania D, Bhandhari K, Kaushal N, Kaur R, Singh K, Srivastava A, Nayyar H (2011) Exogenous proline application reduces phytotoxic effects of selenium by minimising oxidative stress and improves growth in bean (Phaseolus vulgaris L.) seedlings. Biol Trace Elem Res 140(3):354–367

    CrossRef  CAS  PubMed  Google Scholar 

  • Akbaraly TN, Arnaud J, Rayman MP, Hininger-Favier I, Roussel AM, Berr C, Fontbonne A (2010) Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective epidemiology of vascular ageing study. Nutr Metab 7:1–7

    CrossRef  CAS  Google Scholar 

  • Akbulut M, Çakır S (2010) The effects of Se phytotoxicity on the antioxidant systems of leaf tissues in barley (Hordeum vulgare L.) seedlings. Plant Physiol Biochem 48(2–3):160–166

    CrossRef  CAS  PubMed  Google Scholar 

  • Alasfar F, Ben-Nakhi M, Khoursheed M, Kehinde EO, Alsaleh M (2011) Selenium is significantly depleted among morbidly obese female patients seeking bariatric surgery. Obes Surg 21:1710–1713

    CrossRef  PubMed  Google Scholar 

  • Alfthan G, Eurola M, Ekholm P, Venäläinen ER, Root T, Korkalainen K, Hartikainen H, Salminen P, Hietaniemi V, Aspila P, Aro A (2015) Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: from deficiency to optimal selenium status of the population. J Trace Elem Med Biol 31:142–147

    CrossRef  CAS  PubMed  Google Scholar 

  • Al-Saleh I, Billedo G, El-Doush I, El-Din M, Yosef G (2006) Selenium and vitamins status in Saudi children. Clin Chim Acta 368:99–109

    CrossRef  CAS  PubMed  Google Scholar 

  • Avila FW, Yang Y, Faquin V, Ramos SJ, Guilherme LRG, Thannhauser TW, Li L (2014) Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified brassica sprouts. Food Chem 165:578–586

    CrossRef  CAS  PubMed  Google Scholar 

  • Azab SF, Saleh SH, Elsaeed WF, Elshafie MA, Sherief M, Esh AM (2014) Serum trace elements in obese Egyptian children: a case-control study. Ital J Pediatr 10:1–7

    Google Scholar 

  • Bachiega P, Salgado JM, de Carvalho JE, Ruiz ALTG, Schwarz K, Tezotto T, Morzelle MC (2016) Antioxidant and antiproliferative activities in different maturation stages of broccoli (Brassica oleracea Italica) biofortified with selenium. Food Chem 190:771–776

    CrossRef  CAS  PubMed  Google Scholar 

  • Bañuelos GS, Lin ZQ (2007) Acceleration of selenium volatilization in seleniferous agricultural drainage sediments amended with methionine and casein. Environ Pollut 150:306–312

    CrossRef  PubMed  CAS  Google Scholar 

  • Bañuelos GS, Arroyo I, Pickering IJ, Yang SI, Freeman JL (2015) Selenium biofortification of broccoli and carrots grown in soil amended with Se-enriched hyperaccumulator Stanleya pinnata. Food Chem 166:603–608

    CrossRef  PubMed  CAS  Google Scholar 

  • Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (2016) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London

    Google Scholar 

  • Bissardon C, Charlet L, Bohic S, Khan I (2016) Role of the selenium in articular cartilage metabolism, growth, and maturation. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 77–78

    Google Scholar 

  • Blass SC, Goost H, Burger C, Tolba RH, Stoffel-Wagner B, Stehle P, Ellinger S (2013) Extracellular micronutrient levels and pro−/antioxidant status in trauma patients with wound healing disorders: results of a cross-sectional study. Nutr J 12:1–7

    CrossRef  CAS  Google Scholar 

  • Błażewicz A, Klatka M, Astel A, Korona-Glowniak I, Dolliver W, Szwerc W, Kocjan R (2015) Serum and urinary selenium levels in obese children: a cross-sectional study. J Trace Elem Med Biol 29:116–122

    CrossRef  PubMed  CAS  Google Scholar 

  • Boldrin PF, Faquin V, Ramos SJ, Boldrin KVF, Avila FW, Guilherme LRG (2013) Soil and foliar application of selenium in rice biofortification. J Food Compos Anal 31:238–244

    CrossRef  CAS  Google Scholar 

  • Brigelius-Flohé R, Sies H (2016) Diversity of selenium functions in health and disease. Oxidative stress and disease series, vol 38. CRC/Press Taylor & Francis, Boca Raton

    Google Scholar 

  • Bülow Pedersen I, Knudsen N, Carlé A, Schomburg L, Köhrle J, Jørgensen T, Rasmussen L (2013) Serum selenium is low in newly diagnosed graves’ disease: a population-based study. Clin Endocrinol 79:584–590

    CrossRef  CAS  Google Scholar 

  • Carvalho GS (2011) Selenium and mercury in cerrados soils of Brazil. PhD thesis in Soil Science. Federal University of Lavras, Brazil

    Google Scholar 

  • Chawla R, Loomba R, Chaudhary RJ, Singh S, Dhillon KS (2016) Impact of high selenium exposure on organ function & biochemical profile of the rural population living in seleniferous soils in Punjab, India. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 93–94

    Google Scholar 

  • Chen Y, Mo HZ, Hu LB, Li YQ, Chen J, Yang LF (2014) The endogenous nitric oxide mediates selenium-induced phytotoxicity by promoting ROS generation in Brassica rapa. PLoS One 9(10):e110901

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Chilimba ADC, Young SD, Black CR, Meacham MC, Lammel J, Broadley MR (2012) Agronomic biofortification of maize with selenium (Se) in Malawi. Field Crop Res 125:118–128

    CrossRef  Google Scholar 

  • Clark RF, Strukle E, Williams SR, Manoguerra AS (1996) Selenium poisoning from a nutritional supplement. JAMA 275(14):1087–1088

    CrossRef  CAS  PubMed  Google Scholar 

  • Combs GF (2001) Selenium in global food systems. Brit J Nutr 85:517–547

    CrossRef  CAS  PubMed  Google Scholar 

  • Combs GF Jr (2016) Who can benefit from selenium? In: Brigelius-Flohé R, Sies H (eds) Diversity of selenium functions in health and disease, Oxidative stress and disease series, vol 38. CRC Press/Taylor & Francis, Boca Raton, pp 3–15

    Google Scholar 

  • Dhillon KS, Dhillon SK (2009a) Accumulation and distribution of selenium in some vegetable crops grown in selenate-Se treated clay loam soil. Front Agric China 3(4):366–373

    CrossRef  Google Scholar 

  • Dhillon KS, Dhillon SK (2009b) Selenium concentrations of common weeds and agricultural crops grown in the seleniferous soils of northwestern India. Sci Total Environ 407:6150–6156

    CrossRef  CAS  PubMed  Google Scholar 

  • Dhillon KS, Dhillon SK (2014) Development and mapping of seleniferous soils in northwestern India. Chemosphere 99:56–63

    CrossRef  CAS  PubMed  Google Scholar 

  • Dhillon KS, Dhillon SK (2016a) Selenium in groundwater and its contribution towards daily dietary Se intake under different hydrogeological zones of Punjab. J Hydrol 533:615–626

    CrossRef  CAS  Google Scholar 

  • Dhillon KS, Dhillon SK (2016b) Phytoremediation of selenium contaminated soils: strategies and limitations. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 201–202

    Google Scholar 

  • Dhillon SK, Dhillon KS, Kohli A, Khera KL (2008) Evaluation of leaching and runoff losses of selenium from seleniferous soils through simulated rainfall. J Plant Nutr Soil Sci 171:187–192

    CrossRef  CAS  Google Scholar 

  • Domingues CRS, Pascoalino JAL, Moraes MF, Santos CLR, Reis AR, Franco FA, Evangelista A, Scheeren PL (2016) Wheat biofortification: genotypic variation and selenium fertilization in Brazil. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 183–184

    Google Scholar 

  • dos Reis AR (2016) Selenium status in Brazilian soils and crops: agronomic biofortification as a strategy to improve food quality. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 179–180

    Google Scholar 

  • Eiche E, Bardelli F, Nothstein AK, Charlet L, Göttlicher J, Steininger R, Dhillon KS, Sadana US (2015) Selenium distribution and speciation in plant parts of wheat (Triticum aestivum) and Indian mustard (Brassica juncea) from a seleniferous area of Punjab. Sci Total Environ 505:952–961

    CrossRef  CAS  PubMed  Google Scholar 

  • Ekanayake LJ, Thavarajah D, Vial E, Schatz B, McGee R, Thavarajah P (2015) Selenium fertilization on lentil (Lens culinaris Medikus) grain yield, seed selenium concentration, and antioxidant activity. Field Crop Res 177:9–14

    CrossRef  Google Scholar 

  • El Mehdawi AF, Pilon-Smits EA (2012) Ecological aspects of plant selenium hyperaccumulation. Plant Biol (Stuttg) 14(1):1–10

    CrossRef  CAS  Google Scholar 

  • Elemraid MA, Mackenzie IJ, Fraser WD, Harper G, Faragher B, Atef Z, Al-Aghbari N, Brabin BJ (2011) A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children. Eur J Clin Nutr 65:895–902

    CrossRef  CAS  PubMed  Google Scholar 

  • El-Ramady H, Abdalla N, Alshaal T, El-Henawy A, Faizy S. E-D A, Shams M S, Shalaby T, Bayoumi Y, Elhawat N, Shehata S, Sztrik A, Prokisch J, Fári M, Pilon-Smits E A, Domokos-Szabolcsy É (2015a). Selenium and its role in higher plants. In: Lichtfouse E, Schwarzbauer J, Robertet D (eds.), Environ Chem Sustainable World 7:235–296.

    Google Scholar 

  • El-Ramady H, Domokos-Szabolcsy É, Shalaby T A, Prokisch J, Fári M (2015b). Selenium in agriculture: water, air, soil, plants, food, animals and nanoselenium. In: Lichtfouse E (ed.), Environ Chem Sustainable World 5:153–232.

    Google Scholar 

  • El-Ramady H, Abdalla N, Alshaal T, Domokos-Szabolcsy É, Elhawat N, Prokisch J, Sztrik A, Fári M, El-Marsafawy S, Shams MS (2015c) Selenium in soils under climate change, implication for human health. Environ Chem Lett 13(1):1–19

    CrossRef  CAS  Google Scholar 

  • El-Ramady H, Alshaal T, Abdalla N, Prokisch J, Sztrik A, Fári M, Domokos-Szabolcsy É (2016a) Selenium and nano-selenium biofortified sprouts using micro-farm systems. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 189–190

    Google Scholar 

  • El-Ramady H, Abdalla N, Taha HS, Alshaal T, El-Henawy A, Faizy SE-DA, Shams MS, Youssef MS, Shalaby T, Bayoumi Y, Elhawat N, Shehata S, Sztrik A, Prokisch J, Fári M, Domokos-Szabolcsy É, Pilon-Smits EA, Selmar D, Haneklaus S, Schnug E (2016b) Selenium and nano-selenium in plant nutrition. Environ Chem Lett 14(1):123–147

    CrossRef  CAS  Google Scholar 

  • El-Yazigi A, Legayada E (1996) Urinary selenium in healthy and diabetic Saudi Arabians. Biol Trace Elem Res 52:55–63

    CrossRef  CAS  PubMed  Google Scholar 

  • Fairweather-Tait SJ, Bao YP, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease. Antioxid Redox Signal 14:1337–1383

    CrossRef  CAS  PubMed  Google Scholar 

  • Faria LAF (2009) Overview Selenium Quantity in Soils and Plants of State São Paulo, and Selenium Application on Different Forages. PhD thesis in Animal Science, The University São Paulo, Brazil. 57p.

    Google Scholar 

  • Faria L A, Machado M C, Abdalla A L, Righeto P P, Campos L L, Karp F H S, Kamogawa M Y (2016). Agronomic biofortification of Brachiaria with selenium along with urea. In: Bañuelos G S, Lin Z-Q, de Moraes MF, Guilherme L R G, and Reis A R (Eds.), Global advances in selenium research from theory to application, CRC/Taylor & Francis Group, London, pp: 159–160.

    Google Scholar 

  • Fenech M, Wu J, Graham R, Lyons G (2013). Selenium biofortified wheat. In: Preedy V R, Srirajaskanthan R, Patel V B. Handbook of food fortification and health: from concepts to public health applications volume 1. Nutrition and health. Springer Science + Business Media New York, pp. 349–356.

    Google Scholar 

  • Feng R, Wei C, Tu D (2013). The roles of selenium in protecting plants against abiotic stress. Environ Exp Bot 87:58–68.

    Google Scholar 

  • Ferreira KS, Gomes JC, Bellato CR, Jordão CP (2002) Selenium content in Brazilian foods. Pan Am J Public Health 11(3):171–177

    CrossRef  Google Scholar 

  • Fordyce FM (2013) Selenium deficiency and toxicity in the environment. In: Selinus O (ed.), Essentials of Medical Geology: Rev Edn, British Geological Survey, pp 375–419

    Google Scholar 

  • Frankenberger WT Jr, Benson S (1994) Selenium in the environment. Marcel Dekkar, New York, 456p

    Google Scholar 

  • Galinha C, Freitas MC, Pacheco AMG, Coutinho J, Macas B, Almeida AS (2013) Selenium supplementation of Portuguese wheat cultivars through foliar treatment in actual field conditions. J Radioanal Nucl Chem 297:227–231

    CrossRef  CAS  Google Scholar 

  • Galinha C, Sánchez-Martínez M, Pacheco AMG, do Carmo Freitas M, Coutinho J, Maçãs B, Sofia Almeida A, Teresa Pérez-Corona M, Madrid Y, Wolterbeek HT (2015) Characterization of selenium-enriched wheat by agronomic biofortification. J Food Sci Technol 52(7):4236–4245

    CrossRef  CAS  PubMed  Google Scholar 

  • Gao J, Liu Y, Huang Y, Lin Z, Bañuelos GS, Lam MH-W, Yin X (2011) Daily selenium intake in a moderate selenium deficiency area of Suzhou. Food Chem 126(3):1088–1093

    CrossRef  CAS  Google Scholar 

  • Gojkovic Ž, Garbayo I, Luis GJ, Ariza I, Márová C, Vílchez (2015) Selenium bioaccumulation and toxicity in cultures of green microalgae. Algal Res 7:106–116

    CrossRef  Google Scholar 

  • Gong P, Li T, Wang A, Sun F, Gu S, Yin X, Guan W (2014) Screening wheat genotypes for selenium biofortification in Brazil. In: Baňuelos GS, Lin Z–Q, Yin XB (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 142–143

    Google Scholar 

  • Gupta S, Gupta M (2015) Alleviation of selenium toxicity in Brassica juncea L.: salicylic acid-mediated modulation in toxicity indicators, stress modulators, and sulfur-related gene transcripts. Protoplasma 253(6):1–14

    Google Scholar 

  • Han J, Liang H, Yi J, Tan W, He S, Wu X, Shi X, Ma J, Guo X (2016) Selenium deficiency induced damages and altered expressions of metalloproteinases and their inhibitors (MMP1/3, TIMP1/3) in the kidneys of growing rats. J Trace Elem Med Biol 34:1–9

    CrossRef  CAS  PubMed  Google Scholar 

  • Handa N, Bhardwaj R, Poonam HK, Kapoor D, Rattan A, Kaur S, Thukral AK, Kaur S, Arora S, Kapoor N (2016) Selenium: an antioxidant protectant in plants under stress. In: Ahmed P (ed) Plant metal interaction. Elsevier, Amsterdam, pp 179–208

    CrossRef  Google Scholar 

  • Harris J, Schneberg KA, Pilon-Smits EAH (2014) Sulfur–selenium–molybdenum interactions distinguish selenium hyperaccumulator Stanleya pinnata from non-hyperaccumulator Brassica juncea (Brassicaceae). Planta 239:479–491

    CrossRef  CAS  PubMed  Google Scholar 

  • Hatfield DL, Berry MJ, Gladyshev VN (2012) Selenium: its molecular biology and role in human health. Springer, New York

    CrossRef  Google Scholar 

  • Hauser-Davis RA, Silva JAN, Rocha RCC, Saint’Pierre T, Ziolli RL, Arruda MAZ (2016) Acute selenium selenite exposure effects on oxidative stress biomarkers and essential metals and trace-elements in the model organism zebrafish (Danio rerio). J Trace Elem Med Biol 33:68–72

    CrossRef  CAS  PubMed  Google Scholar 

  • Hawrylak-Nowak B (2013) Comparative effects of selenite and selenate on growth and selenium accumulation in lettuce plants under hydroponic conditions. Plant Growth Regul 70(2):149–157

    CrossRef  CAS  Google Scholar 

  • Hawrylak-Nowak B, Matraszek R, Pogorzelec M (2015) The dual effects of two inorganic selenium forms on the growth, selected physiological parameters and macronutrients accumulation in cucumber plants. Acta Physiol Plant 37:41

    CrossRef  CAS  Google Scholar 

  • Hladu KR, Parker DR, Tran KD, Trumble JT (2013) Effects of selenium accumulation on phytotoxicity, herbivory, and pollination ecology in radish (Raphanus sativus L.) Environ Pollut 172:70–75

    CrossRef  CAS  Google Scholar 

  • Hoffmann PR (2016) Selenium as a regulator of immune and inflammatory responses. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London

    Google Scholar 

  • Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE (2015) Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer 136(5):1149–1161

    CrossRef  CAS  PubMed  Google Scholar 

  • Hurst R, Collings R, Harvey L, King M, Hooper L, Bouwman J, Gurinovic M, Fairweather-Tait SJ (2013) EURRECA – estimating selenium requirements four deriving dietary reference values. Crit Rev Food Sci 53:1077–1096

    CrossRef  CAS  Google Scholar 

  • Jaworska K, Gupta S, Durda K, Muszyńska M, Sukiennicki G, Jaworowska E, Grodzki T, Sulikowski M, Waloszczyk P, Wójcik J (2013) A low selenium level is associated with lung and laryngeal cancers. PLoS One 8:e59051

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Kabata-Pendias A, Mukherjee AB (2007) Trace elements from soil to human. Springer, Berlin/Heidelberg/New York

    CrossRef  Google Scholar 

  • Kieliszek M, Błażejak S, Płaczek M (2016) Spectrophotometric evaluation of selenium binding by Saccharomyces cerevisiae ATCC MYA-2200 and Candida utilis ATCC 9950 yeast. J Trace Elem Med Biol 35:90–96

    CrossRef  CAS  PubMed  Google Scholar 

  • Klein EA, Thompson IM, Tangen CM, Crowley JJ, Lucia MS, Goodman FJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, Karp DD, Lieber MM, Walther PJ, Klotz L, Parsons JK, Chin JL, Darke AK, Lippman SM, Goodman GE, Meyskens FL, Baker LH (2011) Vitamin E and the risk of prostate cancer the selenium and vitamin E cancer prevention trial (SELECT). JAMA 306(14):1549–1556

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Kong L, Wang M, Bi D (2005) Selenium modulates the activities of antioxidant enzymes, osmotic homeostasis, and promotes the growth of sorrel seedlings under salt stress. Plant Growth Regul 45:155–163

    CrossRef  CAS  Google Scholar 

  • Koszta G, Kacska Z, Szatmári K, Szerafin T, Fülesdi B (2012) Lower whole blood selenium level is associated with higher operative risk and mortality following cardiac surgery. J Anesth 26:812–821

    CrossRef  PubMed  Google Scholar 

  • Koukkou E, Ilias I, Alexiou M, Mamali I, Nicopoulou S, Alevizaki M, Markou K (2014) Urine selenium changes during pregnancy do not correlate with thyroid autoantibodies in a mildly iodine deficient population. Biol Trace Elem Res 157:9–13

    CrossRef  CAS  PubMed  Google Scholar 

  • Krohn RM, Lemaire M, Silva LFN, Lemarié C, Bolt A, Mann KK, Smits JE (2016) High-selenium lentil diet protects against arsenic-induced atherosclerosis in a mouse model. J Nutr Biochem 27:9–15

    CrossRef  CAS  PubMed  Google Scholar 

  • Lampis S, Zonaro E, Bertolini C, Cecconi D, Monti F, Micaroni M, Turner RJ, Butler CS, Vallini G (2016) Selenite biotransformation and detoxification by Stenotrophomonas maltophilia SeITE02: novel clues on the route to bacterial biogenesis of selenium nanoparticles. J Hazard Mater S0304-3894(16):30162–30165

    Google Scholar 

  • Lazo-Vélez MA, Chávez-Santoscoy A, Serna-Saldivar SO (2015) Selenium-enriched breads and their benefits in human nutrition and health as affected by agronomic, milling, and baking factors. Cereal Chem 92(2):134–144

    CrossRef  CAS  Google Scholar 

  • Lehotai N, Lyubenova L, Schröder P, Feigl G, Ördög A, Szilágyi K, Erdei L, Kolbert Z (2015) Nitro-oxidative stress contributes to selenite toxicity in pea (Pisum sativum L). Plant Soil 400:107–122

    CrossRef  CAS  Google Scholar 

  • Li N, Gao ZD, Luo DG, Tang X, Chen D, Hu Y (2007) Selenium level in the environment and the population of Zhoukoudian area. Sci Total Environ 381(1):105–111

    CrossRef  CAS  PubMed  Google Scholar 

  • Li T, Wang A, Gong P, Gu S, Yuan L, Li F, Yin X, Guan W (2014) Microbial-enhanced selenium biofortification of wheat (Triticum aestivum L.) In: Baňuelos GS, Lin Z-Q, Yin X (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 138–139

    Google Scholar 

  • Li M Q, Hasan M K, Li C X, Ahammed G J, Xia X J, Shi K, Zhou Y H, Reiter R J, Yu J Q, Xu M X, Zhou J. (2016). Melatonin mediates selenium-induced tolerance to cadmium stress to tomato plants. J Pineal Res June 6.

    Google Scholar 

  • Longchamp M, Castrec-Rouelle M (2014) Uptake of selenate versus selenite in Zea mays: biofortification of crops and forage. In: Banuelos GS, Lin Z-Q, Yin X (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 118–119

    Google Scholar 

  • Longchamp M, Angeli N, Castrec-Rouelle M (2013) Selenium uptake in Zea mays supplied with selenate or selenite under hydroponic conditions. Plant Soil 362:107–117

    CrossRef  CAS  Google Scholar 

  • Longchamp M, Castrec-Rouelle M, Biron P, Bariac T (2015) Variations in the accumulation, localization and rate of metabolization of selenium in mature Zea mays plants supplied with selenite or selenate. Food Chem 182:128–135

    CrossRef  CAS  PubMed  Google Scholar 

  • Lopes PA, Santos MC, Vicente L, Rodrigues MO, Pavão ML, Nève J, Viegas-Crespo AM (2004) Trace element status (Se, Cu, Zn) in healthy Portuguese subjects of Lisbon population: a reference study. Biol Trace Elem Res 101:1–17

    CrossRef  CAS  PubMed  Google Scholar 

  • Lyons G, Stangoulis L, Graham R (2003) High-selenium wheat: biofortification for better health. Nutr Res Rev 16:45–60

    CrossRef  CAS  PubMed  Google Scholar 

  • Madaan N, Mudgal V (2011) Phytotoxic effect of selenium on the accessions of wheat and safflower. Res J Environ Sci 5:82–87

    CrossRef  CAS  Google Scholar 

  • Malagoli M, Schiavon M, dall’ Acqua S, Pilon-Smits EAH (2015) Effects of selenium biofortification on crop nutritional quality. Front Plant Sci 6:280

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Manzanares W, Hardy G (2016) Can dietary selenium intake increase the risk of toxicity in healthy children? Nutrition 32(1):149–150

    CrossRef  CAS  PubMed  Google Scholar 

  • Mao H, Lyons GH, Wang ZH (2016) Using agronomic biofortification to reduce micronutrient deficiency in food crops on loess soil in China. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 163–164

    Google Scholar 

  • Massadeh A, Gharibeh A, Omari K, Al-Momani I, Alomary A, Tumah H, Hayajneh W (2010) Simultaneous determination of Cd, Pb, Cu, Zn, and Se in human blood of Jordanian smokers by ICP-OES. Biol Trace Elem Res 133:1–11

    CrossRef  CAS  PubMed  Google Scholar 

  • Mechora S, Stibilj V, Germ M (2015) Response of duckweed to various concentrations of selenite. Environ Sci Pollut Res 22:2416–2422

    CrossRef  CAS  Google Scholar 

  • Menezes C, Marins A, Murussi C, Pretto A, Leitemperger J, Loro VL (2016) Effects of diphenyl diselenide on growth, oxidative damage, and antioxidant response in silver catfish. Sci Total Environ 542:231–237

    CrossRef  CAS  PubMed  Google Scholar 

  • Millán EA, Florea D, Sáez Pérez L, Molina JL, López-González B, Cruz PA, Planells del Pozo E (2012) Deficient selenium status of a healthy adult Spanish population. Nutr Hosp 27:524–528

    Google Scholar 

  • Molnárová M, Fargasová A (2009) Se (IV) phytotoxicity for monocotyledonae cereals (Hordeum vulgare L., Triticum aestivum L.) and dicotyledonae crops (Sinapis alba L., Brassica napus L.) J Hazard Mater 172(2–3):854–861

    CrossRef  PubMed  CAS  Google Scholar 

  • Mora ML, Durán P, Acuña AJ, Cartes P, Demanet R, Gianfreda L (2015) Improving selenium status in plant nutrition and quality. J Soil Sci Plant Nutr 15(2):486–503

    CAS  Google Scholar 

  • Moreno-Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Boelaert MM, Nève J, Perlmutter N, Vanderpas J (1998) Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112–1120

    CrossRef  CAS  PubMed  Google Scholar 

  • Nagy G, Benko I, Kiraly G, Voros O, Tanczos B, Sztrik A, Takács T, Pocsi I, Prokisch J, Banfalvi G (2015) Cellular and nephrotoxicity of selenium species. J Trace Elem Med Biol 30:160–170

    CrossRef  CAS  PubMed  Google Scholar 

  • Nancharaiah YV, Lens PNL (2015) Selenium biomineralization for biotechnological applications. Trends Biotechnol 33(6):323–330

    CrossRef  CAS  PubMed  Google Scholar 

  • Nawaz F, Ahmad R, Ashraf MY, Waraich EA, Khan SZ (2015) Effect of selenium foliar spray on physiological and biochemical processes and chemical constituents of wheat under drought stress. Ecotoxicol Environ Saf 113:191–200

    CrossRef  CAS  PubMed  Google Scholar 

  • Niedzielski P, Rudnicka M, Wachelka M, Kozak L, Rzany M, Wozniak M, Kaskow Z (2016) Selenium species in selenium fortified dietary supplements. Food Chem 190:454–459

    CrossRef  CAS  PubMed  Google Scholar 

  • Nogueira TAR, Alleoni LRF, He Z, Villanueva FCA, Poggere GC, Abreu Junior CH (2013) Teores naturais e valor de referência de qualidade para selênio em solos do estado de São Paulo. In: XXXIV CONGRESSO BRASILEIRO DE CIÊNCIA DO SOLO, 2013. Anais. Florianópolis. CD-ROM.

    Google Scholar 

  • Obeid O, Elfakhani M, Hlais S, Iskandar M, Batal M, Mouneimne Y, Adra N, Hwalla N (2008) Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of Lebanese adults. Biol Trace Elem Res 123:58–65

    CrossRef  CAS  PubMed  Google Scholar 

  • Oropeza-Moe M, Wisløff H, Bernhoft A (2015) Selenium deficiency associated porcine and human cardiomyopathies. J Trace Elem Med Biol 31:148–156

    CrossRef  CAS  PubMed  Google Scholar 

  • Ortiz-Monasterio I, Cárdenas ME, Lyons GH (2016) Biofortification of irrigated wheat with Se fertilizer: timing, rate, method and type of wheat. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 167–168

    Google Scholar 

  • Pandey C, Gupta M (2015) Selenium and auxin mitigates arsenic stress in rice (Oryza sativa L.) by combining the role of stress indicators, modulators and genotoxicity assay. J Hazard Mater 287:384–391

    CrossRef  CAS  PubMed  Google Scholar 

  • Pilon M, El Mehdawi AF, Cappa JJ, Wang J, Pilon-Smits EAH (2016) Molecular mechanisms of selenium hyperaccumulation in Stanleya pinnata: potential key genes SpSultr1;2 and SpAPS2. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 115–116

    Google Scholar 

  • Pilon-Smits EAH, El-Mehdawi AF, Cappa JJ, Wang J, Cochran AT, Reynolds RJ, Sura de Jong M (2016) New insights into the multifaceted ecological and evolutionary aspects of plant selenium hyperaccumulation. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 125–126

    Google Scholar 

  • Poblaciones MJ, Rodrigo S, Santamaria O, Chen Y, McGrath SP (2014) Selenium accumulation and speciation in biofortified chickpea (Cicer arietinum L.) under Mediterranean conditions. J Sci Food Agric 94(6):1101–1106

    CrossRef  CAS  PubMed  Google Scholar 

  • Pograjc L, Stibilj V, Falnoga I (2012) Impact of intensive physical activity on selenium status. Biol Trace Elem Res 145:291–299

    CrossRef  CAS  PubMed  Google Scholar 

  • Prakash NT (2016) Quantification, speciation and bioaccessibility of selenium from Se-rich cereals cultivated in seleniferous soils of India. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 119–120

    Google Scholar 

  • Qin H-B, Zhu J-M, Liang L, Wang M-S, Su H (2013) The bioavailability of selenium and risk assessment for human selenium poisoning in high-Se areas. Environ Int 52:66–74

    CrossRef  CAS  PubMed  Google Scholar 

  • Rauhamaa P, Kantola M, Viitak A, Kaasik T, Mussalo-Rauhamaa H (2008) Selenium levels of Estonians. Eur J Clin Nutr 62:1075–1078

    CrossRef  CAS  PubMed  Google Scholar 

  • Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241

    CrossRef  CAS  PubMed  Google Scholar 

  • Rayman MP, Wijnen H, Vader H, Kooistra L, Pop V (2011) Maternal selenium status during early gestation and risk for preterm birth. CMAJ 183:49–555

    CrossRef  Google Scholar 

  • Rayman MP, Blundell-Pound G, Pastor-Barriuso R, Guallar E, Steinbrenner H, Stranges S (2012) A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PLoS One 7:e45269

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Reis AR, Guilherme LRG, Moraes MF, Ramos SJ (2014) High-selenium upland rice: agronomic biofortification strategies to improve human nutrition. In: Baňuelos GS, Lin Z-Q, Yin X (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 113–114

    Google Scholar 

  • Reis HPG, Barcelos JPQ, Reis AR, Moraes MF (2016) Genotypic variation and agronomic biofortication of upland rice with selenium. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 175–176

    Google Scholar 

  • Saad K, Farghaly HS, Badry R, Othman HA (2014) Selenium and antioxidant levels decreased in blood of children with breath-holding spells. J Child Neurol 29:1339–1343

    CrossRef  PubMed  Google Scholar 

  • Sah S, Vandenberg A, Smits J (2013) Treating chronic arsenic toxicity with high selenium lentil diets. Toxicol Appl Pharmacol 272(1):256–262

    CrossRef  CAS  PubMed  Google Scholar 

  • Saidi I, Nawel N, Djebali W (2014a) Role of selenium in preventing manganese toxicity in sunflower (Helianthus annuus) seedling. S Afr J Bot 94:88–94

    CrossRef  CAS  Google Scholar 

  • Saidi I, Chtourou Y, Djebali W (2014b) Selenium alleviates cadmium toxicity by preventing oxidative stress in sunflower (Helianthus annuus) seedlings. J Plant Physiol 171(5):85–91

    CrossRef  CAS  PubMed  Google Scholar 

  • Sánchez C, López-Jurado M, Aranda P, Llopis J (2010) Plasma levels of copper, manganese and selenium in an adult population in southern Spain: influence of age, obesity and lifestyle factors. Sci Total Environ 408:1014–1020

    CrossRef  PubMed  CAS  Google Scholar 

  • Schilling K, Johnson TM, Dhillon KS, Mason PRD (2015) Fate of selenium in soils at a seleniferous site recorded by high precision Se isotope measurements. Environ Sci Technol 49:9690–9698

    CrossRef  CAS  PubMed  Google Scholar 

  • Schomburg L (2011) Selenium, selenoproteins and the thyroid gland: interactions in health and disease. Nature 8:160–171

    Google Scholar 

  • Sharma VK (2009) Aggregation and toxicity of titanium dioxide nanoparticles in aquatic environment—a review. Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering 44(14):1485–1495

    CrossRef  CAS  Google Scholar 

  • Sharma N, Prakash R, Srivastava A, Sadana US, Acharya R, Prakash NT, Reddy AVR (2009) Profile of selenium in soil and crops in seleniferous area of Punjab, India by neutron activation analysis. J Radioanal Nucl Chem 281:59–62

    CrossRef  CAS  Google Scholar 

  • Sharma G, Sharma A R, Bhavesh R, Park J, Ganbold B, Nam J-S, Lee S-S. (2014a). Biomolecule-mediated synthesis of selenium nanoparticles using dried Vitis vinifera (Raisin) extract. Molecules, 19: 2761–2770.

    Google Scholar 

  • Sharma S, Kaur N, Kaur S, Nayyar H (2014b) Ascorbic acid reduces the phytotoxic effects of selenium on rice (Oryza sativa L.) by up-regulation of antioxidative and metal-tolerance mechanisms. J Plant Physiol Pathol 2(3)

    Google Scholar 

  • Sharma S, Goyal R, Sandana US (2014c) Selenium accumulation and antioxidant status of rice plants grown on seleniferous soil from northwestern India. Rice Sci 21(6):327–334

    CrossRef  Google Scholar 

  • Sharma P, Aggarwal P, Kaur A (2016) Biofortification: a new approach to eradicate hidden hunger. Food Rev Int 33(1):1–21

    CrossRef  CAS  Google Scholar 

  • Sherief LM, Abd El-Salam SM, Kamal NM, El Safy O, Almalky MA, Azab SF, Morsy HM, Gharieb AF (2014) Nutritional biomarkers in children and adolescents with Betathalassemia-major: an Egyptian center experience. Biomed Res Int 2014:1–7

    CrossRef  CAS  Google Scholar 

  • Silva Junior ED (2016) Selenium in Brazilian nuts (Bertholletia excelsa) and soils from Amazon region. PhD thesis in Soil Science. Federal University of Lavras, Brazil. 75p.

    Google Scholar 

  • Srivastava A, Pathania D, Swain KK, Ajith N, Acharya R, Reddy AVR, Nayyar H (2012) Application of INAA for phyto-accumulation study of selenium by chickpea plant. J Radioanal Nucl Chem 294(2):315–318

    CrossRef  CAS  Google Scholar 

  • Stoffaneller R, Morse NL (2015) A review of dietary selenium intake and selenium status in Europe and the Middle East. Forum Nutr 7(3):1494–1537

    CAS  Google Scholar 

  • Stoppe C, Schälte G, Rossaint R, Coburn M, Graf B, Spillner J, Marx G, Rex S (2011) The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients. Crit Care Med 39:1879–1885

    CrossRef  CAS  PubMed  Google Scholar 

  • Stoppe C, Spillner J, Rossaint R, Coburn M, Schälte G, Wildenhues A, Marx G, Rex S (2013) Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite. Nutrition 29:158–165

    CrossRef  CAS  PubMed  Google Scholar 

  • Stranges S, Laclaustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, Rayman M, Guallar E (2010) Higher selenium status is associated with adverse blood lipid profile in British adults. J Nutr 140:81–87

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Suadicani P, Hein HO, Gyntelberg F (2012) Serum selenium level and risk of lung cancer mortality: a 16-year follow-up of the Copenhagen male study. Eur Respir J 39:1443–1448

    CrossRef  CAS  PubMed  Google Scholar 

  • Sun H, Rathinasabapathi JB, Wu B, Luo J, Pu L-P, Ma LQ (2014) Arsenic and selenium toxicity and their interactive effects in humans. Environ Int 69:148–158

    CrossRef  CAS  PubMed  Google Scholar 

  • Surai P (2006) Selenium in food and feed: selenomethionine and beyond. In: Selenium in nutrition and health. Nottingham University Press, Nottingham, pp 151–212

    Google Scholar 

  • Talukdar D (2013) Selenium priming selectively ameliorates weed – induced phytotoxicity by modulating antioxidant defense components in lentil (Lens culinaris Medik.) and grass pea (Lathyrus sativus L.) Ann Rev Res in Biol 3(3):195–212

    Google Scholar 

  • Tan JA, Zhu WY, Wang WY, Li RB, Wang DC, Yang LS (2002) Selenium in soil and endemic diseases in China. Sci Total Environ 284:227–235

    CrossRef  CAS  PubMed  Google Scholar 

  • Thomson CD (2004) Selenium and iodine intakes and status in New Zealand and Australia. Br J Nutr 91(5):661–672

    CrossRef  CAS  PubMed  Google Scholar 

  • Van Hoewyk D (2013) A tale of two toxicities: malformed selenoproteins and oxidative stress both contribute to selenium stress in plants. Ann Bot 112(6):965–972

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Vinceti M, Crespi CM, Malagoli C, Bottecchi I, Ferrari A, Sieri S, Krogh V, Alber D, Bergomi M, Seidenari S, Pellacani G (2012) A case-control study of the risk of cutaneous melanoma associated with three selenium exposure indicators. Tumori 98:287–295

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Z, Gao Y (2001) Biogeochemical cycling of selenium in Chinese environments. Appl Geochem 16:1345–1351

    CrossRef  CAS  Google Scholar 

  • Wang J, Xiao Y P, Liang X Q, Shao X H, Zhang K (2012). Determination of arsenic, mercury and selenium in Gynostemma pentaphyllum and rhizospheric soil samples collected from different regions by hydride generation atomic fluorescence spectrometry. Guang Pu Xue Yu Guang Pu Fen Xi 32(3):813–816 (in Chinese)

    Google Scholar 

  • Wang X, Tam NF, Fu S, Ametkhan A, Ouyang Y, Ye Z (2014) Selenium addition alters mercury uptake, bioavailability in the rhizosphere and root anatomy of rice (Oryza sativa). Ann Bot 114(2):271–278

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Q, Zhang J, Zhao B, Xin X, Deng X, Zhang H (2016a) Influence of long-term fertilization on selenium accumulation in soil and uptake by crops. Pedosphere 26(1):120–129

    CrossRef  Google Scholar 

  • Wang D, Liu Y, Liu D (2016b) Keshan disease and Kaschin-Beck disease in China: is there still selenium deficiency? In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 95–96

    Google Scholar 

  • White PJ (2016) The genetics of selenium accumulation by plants. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 111–112

    Google Scholar 

  • Wimmer I, Hartmann T, Brustbauer R, Minear G, Dam K (2014) Selenium levels in patients with autoimmune thyroiditis and controls in lower Austria. Horm Metab Res 46:707–709

    CrossRef  CAS  PubMed  Google Scholar 

  • Winkel LHE, Vriens B, Jones GD, Schneider LS, Pilon-Smits EAH, Bañuelos G (2015) Selenium cycling across soil-plant-atmosphere interfaces: a critical review. Forum Nutr 7(6):4199–4239

    CAS  Google Scholar 

  • Wrobel JK, Power R, Toborek M (2016) Biological activity of selenium: revisited. IUBMB Life 68(2):97–105

    CrossRef  CAS  PubMed  Google Scholar 

  • Wu Q, Rayman M, Lu H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B (2015) Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab 100(11):4037–4047

    CrossRef  CAS  PubMed  Google Scholar 

  • Xia Y, Hill KE, Byrne DW, Xu J, Burk RF (2005) Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr 81:829–834

    CAS  PubMed  Google Scholar 

  • Yang H, Jia X (2014) Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: acute toxicity, genotoxicity and subchronictoxicity. Regul Toxicol Pharmacol 70(3):720–727

    CrossRef  CAS  PubMed  Google Scholar 

  • Yasin M, Faisal M, Pilon-Smits EAH (2014) Selenium biofortification and its effects on flour paste viscosity properties in wheat. In: Baňuelos GS, Lin Z-Q, Yin X (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 140–141

    Google Scholar 

  • Yasin M, El-Mehdawi AF, Pilon-Smits EA, Faisal M (2015a) Selenium-fortified wheat: potential of microbes for biofortification of selenium and other essential nutrients. Int J Theor Phys 17(8):777–786

    CAS  Google Scholar 

  • Yasin M, El-Mehdawi AF, Anwar A, Pilon-Smits EA, Faisal M (2015b) Microbial-enhanced selenium and iron biofortification of wheat (Triticum aestivum L.): applications in phytoremediation and biofortification. Int J Theor Phys 17(1–6):341–347

    CAS  Google Scholar 

  • Yasin M, El Mehdawi AF, Jahn CE, Anwar A, Turner MFS, Faisal M, Pilon-Smits EAH (2015c) Seleniferous soils as a source for production of selenium-enriched foods and potential of bacteria to enhance plant selenium uptake. Plant Soil 386:385–394

    CrossRef  CAS  Google Scholar 

  • Yasin M, Faisal M, El Mehdawi AF, Pilon-Smits EAH (2016) Microbe-assisted selenium phytoremediation and phytomanagement of natural seleniferous areas. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC, Taylor & Francis Group, London, pp 199–200

    Google Scholar 

  • Ye S, Zhang J, Liu Z, Zhang Y, Li J, Li YO (2016) Biosynthesis of selenium rich exopolysaccharide (Se-EPS) by Pseudomonas PT-8 and characterization of its antioxidant activities. Carbohydr Polym 142:230–239

    CrossRef  CAS  PubMed  Google Scholar 

  • Yuan L, Yin X, Zhu Y, Li F, Huang Y, Liu Y, Lin Z (2012) Selenium in plants and soils, and selenosis in Enshi, China: implications for selenium biofortification. In: Yin X, Yuan L (eds) Phytoremediation and biofortification. Springer, Dordrecht, pp 7–31

    CrossRef  Google Scholar 

  • Yusuf M, Khan TA, Fariduddin Q (2016) Interaction of epibrassinolide and selenium ameliorates the excess copper in Brassica juncea through altered proline metabolism and antioxidants. Ecotoxicol Environ Saf 129:25–34

    CrossRef  CAS  PubMed  Google Scholar 

  • Zanetti MA, Correa LB, Saran Netto A, Cunha JA, Santana RSS, Cozzolino SMF (2016) Influence of canola oil, vitamin E and selenium on cattle meat quality and its effects on nutrition and health of humans. In: Bañuelos GS, Lin Z-Q, de Moraes MF, Guilherme LRG, Reis AR (eds) Global advances in selenium research from theory to application. CRC/Taylor & Francis Group, London, pp 97–98

    Google Scholar 

  • Zhao J, Gao Y, Li Y-F, Hu Y, Peng X, Dong Y, Li B, Chen C, Chai Z (2013) Selenium inhibits the phytotoxicity of mercury in garlic (Allium sativum). Environ Res 125:75–81

    CrossRef  CAS  PubMed  Google Scholar 

  • Zhu J, Wang N, Li S, Li L, Su H, Liu C (2008) Distribution and transport of selenium in Yutangba, China: impact of human activities. Sci Total Environ 392(2–3):252–261

    CrossRef  CAS  PubMed  Google Scholar 

  • Zhu Y, Yin X, Liu S, Yuan S (2014) The selenium speciation in the seeds of the common wheat genotypes tending to accumulate high concentrations of selenium. In: Baňuelos GS, Lin Z-Q, Yin X (eds) Selenium in the environment and human health. Taylor & Francis Group, London, pp 136–137

    Google Scholar 

  • Zhu X, Jiang M, Song E, Jiang X, Song Y (2015) Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling. Food Chem Toxicol 75:139–145

    CrossRef  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to André Rodrigues dos Reis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

dos Reis, A.R., El-Ramady, H., Santos, E.F., Gratão, P.L., Schomburg, L. (2017). Overview of Selenium Deficiency and Toxicity Worldwide: Affected Areas, Selenium-Related Health Issues, and Case Studies. In: Pilon-Smits, E., Winkel, L., Lin, ZQ. (eds) Selenium in plants. Plant Ecophysiology, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-56249-0_13

Download citation