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Management of Perianal Crohn’s Disease in the Biologic Era

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Abstract

Perianal Crohn’s disease represents a distinct, aggressive phenotype of Crohn’s disease associated with increased morbidity. It encompasses a variety of manifestations including perianal fistula which has a very significant on patient’s quality of life. Anti-TNF therapy has heralded a change in the management of these patients and a combination of medical and surgical treatment is required for most perianal manifestations. A multidisciplinary approach involving gastroenterologists, surgeons, radiologists, IBD nurse specialists and dieticians, and an understanding of all forms of perianal Crohn’s disease and options for treatment are crucial to minimise the often disabling morbidity that can potentially effect this group of patients.

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References

  1. Tarrant KM, Barclay ML, Frampton CM, Gearry RB. Perianal disease predicts changes in Crohn’s disease phenotype-results of a population-based study of inflammatory bowel disease phenotype. Am J Gastroenterol. 2008;103(12):3082–93. doi:10.1111/j.1572-0241.2008.02212.x.

    Article  PubMed  Google Scholar 

  2. Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn’s disease. Ann Surg. 2000;231:38–45. doi:10.1097/00000658-200001000-00006.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Whelan G, Farmer RG, Fazio VW, Goormastic M. Recurrence after surgery in Crohn’s disease. Relationship to location of disease (clinical pattern) and surgical indication. Gastroenterology. 1985;88(6):1826–33.

    Article  CAS  PubMed  Google Scholar 

  4. Satsangi J, Silverberg MS, Vermeire S, Colombel J-F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749–53. doi:10.1136/gut.2005.082909.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Armuzzi A, Ahmad T, Ling K-L, et al. Genotype-phenotype analysis of the Crohn’s disease susceptibility haplotype on chromosome 5q31. Gut. 2003;52(8):1133–9. doi:10.1136/jmg.40.10.792.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn’s disease. Gastroenterology. 2002;122:854–66. doi:10.1053/gast.2002.32413.

    Article  CAS  PubMed  Google Scholar 

  7. Beaugerie L, Seksik P, Nion-Larmurier I, Gendre J-P, Cosnes J. Predictors of Crohn’s disease. Gastroenterology. 2006;130(3):650–6. doi:10.1053/j.gastro.2005.12.019.

    Article  PubMed  Google Scholar 

  8. Eglinton TW, Barclay ML, Gearry RB, Frizelle FA. The spectrum of perianal Crohn’s disease in a population-based cohort. Dis Colon Rectum. 2012;55(7):773–7. doi:10.1097/DCR.0b013e31825228b0.

    Article  PubMed  Google Scholar 

  9. Peyrin-Biroulet L, Loftus EV, Tremaine WJ, Harmsen WS, Zinsmeister AR, Sandborn WJ. Perianal Crohn’s disease findings other than fistulas in a population-based cohort. Inflamm Bowel Dis. 2012;18(1):43–8. doi:10.1002/ibd.21674.

    Article  PubMed  Google Scholar 

  10. Singh B, McC Mortensen NJ, Jewell DP, George B. Perianal Crohn’s disease. Br J Surg. 2004;91(7):801–14. doi:10.1002/bjs.4613.

    Article  CAS  PubMed  Google Scholar 

  11. Hellers G, Bergstrand O, Ewerth S, Holmström B. Occurrence and outcome after primary treatment of anal fistulae in Crohn’s disease. Gut. 1980;21(6):525–7. doi:10.1136/gut.21.6.525.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Tang LY, Rawsthorne P, Bernstein CN. Are perineal and luminal fistulas associated in Crohn’s disease? A population-based study. Clin Gastroenterol Hepatol. 2006;4(9):1130–4. doi:10.1016/j.cgh.2006.06.021.

    Article  PubMed  Google Scholar 

  13. Schwartz DA, Loftus EV, Tremaine WJ, et al. The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology. 2002;122(4):875–80. doi:10.1053/gast.2002.32362.

    Article  PubMed  Google Scholar 

  14. Sangwan YP, Schoetz DJ, Murray JJ, Roberts PL, Coller JA. Perianal Crohn’s disease. Results of local surgical treatment. Dis Colon Rectum. 1996;39(5):529–35.

    Article  CAS  PubMed  Google Scholar 

  15. Hughes LE. Surgical pathology and management of anorectal Crohn’s disease. J R Soc Med. 1978;71(February 1977):644–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Hughes LE. Clinical classification of perianal Crohn’s disease. Dis Colon Rectum. 1992;35(10):928–32.

    Article  CAS  PubMed  Google Scholar 

  17. Pellino G, Selvaggi F. Surgical treatment of perianal fistulizing Crohn’s disease: from lay-open to cell-based therapy—an overview. Sci World J. 2014;2014:146281. doi:10.1155/2014/146281.

    Article  Google Scholar 

  18. Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB. AGA technical review on perianal Crohn’s disease. Gastroenterology. 2003;125(5):1508–30. doi:10.1053/S0016-5085(03)01367-2.

    Article  PubMed  Google Scholar 

  19. Bonheur JL, Braunstein J, Korelitz BI, Panagopoulos G. Anal skin tags in inflammatory bowel disease: new observations and a clinical review. Inflamm Bowel Dis. 2008;14(9):1236–9. doi:10.1002/ibd.20458.

    Article  PubMed  Google Scholar 

  20. Buchmann P, Keighley MRB, Allan RN, Thompson H, Alexander-Williams J. Natural history of perianal Crohn’s disease. Ten year follow-up: a plea for conservatism. Am J Surg. 1980;140(5):642–4. doi:10.1016/0002-9610(80)90048-3.

    Article  CAS  PubMed  Google Scholar 

  21. Keighley M, Allan R. Current status and influence of operation on perianal Crohn’s disease. Int J Colorectal Dis. 1986;1(2):104–7. doi:10.1007/BF01648416.

    Article  CAS  PubMed  Google Scholar 

  22. Keljo DJ, Markowitz J, Langton C, et al. Course and treatment of perianal disease in children newly diagnosed with Crohn’s disease. Inflamm Bowel Dis. 2009;15(3):383–7. doi:10.1002/ibd.20767.

    Article  PubMed  Google Scholar 

  23. Bouguen G, Siproudhis L, Bretagne J-F, Bigard M-A, Peyrin-Biroulet L. Nonfistulizing perianal Crohn’s disease: clinical features, epidemiology, and treatment. Inflamm Bowel Dis. 2010;16(8):1431–42. doi:10.1002/ibd.21261.

    Article  PubMed  Google Scholar 

  24. Somerville KW, Langman MJ, Da Cruz DJ, Balfour TW, Sully L. Malignant transformation of anal skin tags in Crohn’s disease. Gut. 1984;25(0017-5749 (Print)):1124–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Ky A, Sohn N, Weinstein MA, Korelitz BI. Carcinoma arising in anorectal fistulas of Crohn’s disease. Dis Colon Rectum. 1998;41(0012-3706 (Print)):992–6. doi:10.1007/BF02237388.

    Article  CAS  PubMed  Google Scholar 

  26. Frisch M, Johansen C. Anal carcinoma in inflammatory bowel disease. Br J Cancer. 2000;83(0007-0920 (Print)):89–90. doi:10.1054/bjoc.2000.1153.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Sjödahl RI, Myrelid P, Söderholm JD. Anal and rectal cancer in Crohn’s disease. Colorectal Dis. 2003;5(5):490–5. doi:10.1046/j.1463-1318.2003.00510.x.

    Article  PubMed  Google Scholar 

  28. Connell WR, Sheffield JP, Kamm MA, Ritchie JK, Hawley PR, Lennard-Jones JE. Lower gastrointestinal malignancy in Crohn’s disease. Gut. 1994;35(0017-5749 (Print)):347–52. doi:10.1136/gut.35.3.347.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Williams DR, Coller JA, Corman ML, Warren Nugent F, Veidenheimer MC. Anal complications in Crohn’s disease. Dis Colon Rectum. 1981;24:22–4. doi:10.1007/BF02603444.

    Article  CAS  PubMed  Google Scholar 

  30. Wolff BG, Culp CE, Beart Jr RW, Ilstrup DM, Ready RL. Anorectal Crohn’s disease. A long-term perspective. Dis Colon Rectum. 1985;28(10):709–11.

    Article  CAS  PubMed  Google Scholar 

  31. Sweeney JL, Ritchie JK, Nicholls RJ. Anal fissure in Crohn’s disease. Br J Surg. 1988;75(1):56–7.

    Article  CAS  PubMed  Google Scholar 

  32. Buchmann P, Alexander-Williams J. Classification of perianal Crohn’s disease. Clin Gastroenterol. 1980;9(2):323–30.

    CAS  PubMed  Google Scholar 

  33. Fleshner PR, Schoetz Jr DJ, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC. Anal fissure in Crohn’s disease: a plea for aggressive management. Dis Colon Rectum. 1995;38(11):1137–43.

    Article  CAS  PubMed  Google Scholar 

  34. Wolkomir AF, Luchtefeld MA. Surgery for symptomatic hemorrhoids and anal fissures in Crohn’s disease. Dis Colon Rectum. 1993;36(6):545–7.

    Article  CAS  PubMed  Google Scholar 

  35. D’Ugo S, Franceschilli L, Cadeddu F, et al. Medical and surgical treatment of haemorrhoids and anal fissure in Crohn’s disease: a critical appraisal. BMC Gastroenterol. 2013;13(1):47. doi:10.1186/1471-230X-13-47.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Bouguen G, Trouilloud I, Siproudhis L, et al. Long-term outcome of non-fistulizing (ulcers, stricture) perianal Crohn’s disease in patients treated with infliximab. Aliment Pharmacol Ther. 2009;30(7):749–56. doi:10.1111/j.1365-2036.2009.04089.x.

    Article  CAS  PubMed  Google Scholar 

  37. Zaghiyan K, Fleshner P. Anal fissure. Clin Colon Rectal Surg. 2011;24(01):022–30. doi:10.1055/s-0031-1272820.

    Article  Google Scholar 

  38. Siproudhis L, Mortaji A, Mary JY, Juguet F, Bretagne JF, Gosselin M. Anal lesions: any significant prognosis in Crohn’s disease? Eur J Gastroenterol Hepatol. 1997;9(3):239–43.

    Article  CAS  PubMed  Google Scholar 

  39. Alexander-Williams J, Buchmann P. Perianal Crohn’s disease. World J Surg. 1980;4(2):203–8.

    Article  CAS  PubMed  Google Scholar 

  40. Stringer EE, Nicholson TJ, Armstrong D. Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn’s disease. Dis Colon Rectum. 2005;48(5):970–4. doi:10.1007/s10350-004-0873-8.

    Article  PubMed  Google Scholar 

  41. Casson DH, Eltumi M, Tomlin S, Walker-Smith JA, Murch SH. Topical tacrolimus may be effective in the treatment of oral and perineal Crohn’s disease. Gut. 2000;47(3):436–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Hart AL, Plamondon S, Kamm MA. Topical tacrolimus in the treatment of perianal Crohn’s disease: exploratory randomized controlled trial. Inflamm Bowel Dis. 2007;13(3):245–53. doi:10.1002/ibd.20073.

    Article  PubMed  Google Scholar 

  43. Ouraghi A, Nieuviarts S, Mougenel JL, et al. Infliximab therapy for Crohn’s disease anoperineal lesions. Gastroenterol Clin Biol. 2001;25(11):949–56.

    CAS  PubMed  Google Scholar 

  44. Linares L, Moreira LF, Andrews H, Allan RN, Alexander-Williams J, Keighley MR. Natural history and treatment of anorectal strictures complicating Crohn’s disease. Br J Surg. 1988;75(7):653–5.

    Article  CAS  PubMed  Google Scholar 

  45. Fields S, Rosainz L, Korelitz BI, Panagopoulos G, Schneider J. Rectal strictures in Crohn’s disease and coexisting perirectal complications. Inflamm Bowel Dis. 2008;14(1):29–31. doi:10.1002/ibd.20264.

    Article  PubMed  Google Scholar 

  46. Galandiuk S, Kimberling J, Al-Mishlab TG, Stromberg AJ. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg. 2005;241(5):796–801. discussion 801–2 doi:10.1097/01.sla.0000161030.25860.c1.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Greenstein AJ, Sachar DB, Kark AE. Stricture of the anorectum in Crohn’s disease involving the colon. Ann Surg. 1975;181(2):207–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. McClane SJ, Rombeau JL. Anorectal Crohn’s disease. Surg Clin North Am. 2001;81(1):169–83. ix

    Article  CAS  PubMed  Google Scholar 

  49. Bernard D, Morgan S, Tassé D. Selective surgical management of Crohn’s disease of the anus. Can J Surg. 1986;29(5):318–21.

    CAS  PubMed  Google Scholar 

  50. de Zoeten EF, Pasternak BA, Mattei P, Kramer RE, Kader HA. Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement. J Pediatr Gastroenterol Nutr. 2013;57(3):401–12. doi:10.1097/MPG.0b013e3182a025ee.

    Article  PubMed  Google Scholar 

  51. Nielsen MB, Rasmussen OO, Pedersen JF, Christiansen J. Risk of sphincter damage and anal incontinence after anal dilatation for fissure-in-ano. An endosonographic study. Dis Colon Rectum. 1993;36(7):677–80.

    Article  CAS  PubMed  Google Scholar 

  52. Mizrahi N, Wexner SD, Zmora O, et al. Endorectal advancement flap: are there predictors of failure? Dis Colon Rectum. 2002;45(12):1616–21. doi:10.1097/01.DCR.0000037654.01119.CD.

    Article  PubMed  Google Scholar 

  53. Sonoda T, Hull T, Piedmonte MR, Fazio VW. Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis Colon Rectum. 2002;45(12):1622–8. doi:10.1097/01.DCR.0000037653.68665.E8.

    Article  PubMed  Google Scholar 

  54. Parks AG. Pathogenesis and treatment of fistula-in-ano. Br Med J. 1961;12:463–70. doi:10.1136/bmj.1.5224.463.

    Article  Google Scholar 

  55. Eglinton TW, Roberts R, Pearson J, et al. Clinical and genetic risk factors for perianal Crohn’s disease in a population-based cohort. Am J Gastroenterol. 2012;107(4):589–96. doi:10.1038/ajg.2011.437.

    Article  CAS  PubMed  Google Scholar 

  56. Vermeire S, Pierik M, Hlavaty T, et al. Association of organic cation transporter risk haplotype with perianal penetrating Crohn’s disease but not with susceptibility to IBD. Gastroenterology. 2005;129(6):1845–53. doi:10.1053/j.gastro.2005.10.006.

    Article  CAS  PubMed  Google Scholar 

  57. Latiano A, Palmieri O, Cucchiara S, et al. Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn’s disease. Am J Gastroenterol. 2009;104(1):110–6. doi:10.1038/ajg.2008.3.

    Article  CAS  PubMed  Google Scholar 

  58. Angelberger S, Reinisch W, Dejaco C, et al. NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn’s disease. Am J Gastroenterol. 2008;103(5):1197–202. doi:10.1111/j.1572-0241.2007.01741.x.

    Article  CAS  PubMed  Google Scholar 

  59. Chen W, Li D, Wilson I, Chadwick VS. Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls. J Gastroenterol Hepatol. 2002;17(9):987–93.

    Article  CAS  PubMed  Google Scholar 

  60. Romero C, Hamdi A, Valentine JF, Naser SA. Evaluation of surgical tissue from patients with Crohn’s disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction. Inflamm Bowel Dis. 2005;11(2):116–25.

    Article  PubMed  Google Scholar 

  61. Seow-Choen F, Hay AJ, Heard S, Phillips RK. Bacteriology of anal fistulae. Br J Surg. 1992;79(1):27–8.

    Article  CAS  PubMed  Google Scholar 

  62. West RL, Van der Woude CJ, Endtz HP, et al. Perianal fistulas in Crohn’s disease are predominantly colonized by skin flora: implications for antibiotic treatment? Dig Dis Sci. 2005;50(7):1260–3.

    Article  CAS  PubMed  Google Scholar 

  63. Makowiec F, Jehle EC, Becker HD, Starlinger M. Perianal abscess in Crohn’s disease. Dis Colon Rectum. 1997;40(4):443–50.

    Article  CAS  PubMed  Google Scholar 

  64. Haggett PJ, Moore NR, Shearman JD, Travis SP, Jewell DP, Mortensen NJ. Pelvic and perineal complications of Crohn’s disease: assessment using magnetic resonance imaging. Gut. 1995;36(3):407–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Parks AG, Thomson JP. Intersphincteric abscess. Br Med J. 1973;2(5865):537–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Viganò C, Losco A, Caprioli F, Basilisco G. Incidence and clinical outcomes of intersphincteric abscesses diagnosed by anal ultrasonography in patients with Crohnʼs disease. Inflamm Bowel Dis. 2011;17(10):2102–8. doi:10.1002/ibd.21596.

    Article  PubMed  Google Scholar 

  67. Gecse KB, Bemelman W, Kamm MA, et al. A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn’s disease. Gut. 2014;63(9):1381–92. doi:10.1136/gutjnl-2013-306709.

    Article  PubMed  Google Scholar 

  68. Thia KT, Mahadevan U, Feagan BG, et al. Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn’s disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis. 2009;15(1):17–24. doi:10.1002/ibd.20608.

    Article  PubMed  Google Scholar 

  69. West RL, van der Woude CJ, Hansen BE, et al. Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn’s disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2004;20(11–12):1329–36. doi:10.1111/j.1365-2036.2004.02247.x.

    Article  CAS  PubMed  Google Scholar 

  70. Oliver I, Lacueva FJ, Pérez Vicente F, et al. Randomized clinical trial comparing simple drainage of anorectal abscess with and without fistula track treatment. Int J Colorectal Dis. 2003;18(2):107–10. doi:10.1007/s00384-002-0429-0.

    CAS  PubMed  Google Scholar 

  71. Ardizzone S, Porro GB. Perianal Crohn’s disease: overview. Dig Liver Dis. 2007;39(10):957–8. doi:10.1016/j.dld.2007.07.152.

    Article  CAS  PubMed  Google Scholar 

  72. Mahadev S, Young JM, Selby W, Solomon MJ. Quality of life in perianal Crohn’s disease: what do patients consider important? Dis Colon Rectum. 2011;54(5):579–85. doi:10.1007/DCR.0b013e3182099d9e.

    Article  PubMed  Google Scholar 

  73. Bissell AD. Localized chronic ulcerative ileitis. Ann Surg. 1934;99(6):957–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Castaño-Milla C, Chaparro M, Saro C, et al. Effectiveness of adalimumab in perianal fistulas in Crohn’s disease patients naive to anti-TNF therapy. J Clin Gastroenterol. 2015;49(1):34–40. doi:10.1097/MCG.0000000000000169.

    Article  PubMed  CAS  Google Scholar 

  75. Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis. 2002;8(4):244–50.

    Article  PubMed  Google Scholar 

  76. Karban A, Itay M, Davidovich O, et al. Risk factors for perianal Crohn’s disease: the role of genotype, phenotype, and ethnicity. Am J Gastroenterol. 2007;102(8):1702–8. doi:10.1111/j.1572-0241.2007.01277.x.

    Article  PubMed  Google Scholar 

  77. Ingle SB, Loftus EV. The natural history of perianal Crohn’s disease. Dig Liver Dis. 2007;39(10):963–9. doi:10.1016/j.dld.2007.07.154.

    Article  CAS  PubMed  Google Scholar 

  78. Hanley PH. Reflections on anorectal abscess fistula: 1984. Dis Colon Rectum. 1985;28(7):528–33.

    Article  CAS  PubMed  Google Scholar 

  79. Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg. 1976;63(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  80. Seow-Choen, Phillips RK. Insights gained from the management of problematical anal fistulae at St. Mark’s Hospital, 1984–88. Br J Surg. 1991;78(5):539–41.

    Article  CAS  PubMed  Google Scholar 

  81. Halligan S, Buchanan G. MR imaging of fistula-in-ano. Eur J Radiol. 2003;47(2):98–107.

    Article  PubMed  Google Scholar 

  82. Tozer PJ, Burling D, Gupta A, Phillips RKS, Hart AL. Review article: medical, surgical and radiological management of perianal Crohn’s fistulas. Aliment Pharmacol Ther. 2011;33(1):5–22. doi:10.1111/j.1365-2036.2010.04486.x.

    Article  CAS  PubMed  Google Scholar 

  83. Siddiqui MRS, Ashrafian H, Tozer P, et al. A diagnostic accuracy meta-analysis of endoanal ultrasound and MRI for perianal fistula assessment. Dis Colon Rectum. 2012;55(5):576–85. doi:10.1097/DCR.0b013e318249d26c.

    Article  PubMed  Google Scholar 

  84. Barker PG, Lunniss PJ, Armstrong P, Reznek RH, Cottam K, Phillips RK. Magnetic resonance imaging of fistula-in-ano: technique, interpretation and accuracy. Clin Radiol. 1994;49(1):7–13.

    Article  CAS  PubMed  Google Scholar 

  85. deSouza NM, Williams AD, Gilderdale DJ. High-resolution magnetic resonance imaging of the anal sphincter using a dedicated endoanal receiver coil. Eur Radiol. 1999;9(3):436–43. doi:10.1007/s003300050688.

    Article  CAS  PubMed  Google Scholar 

  86. Spencer JA, Chapple K, Wilson D, Ward J, Windsor AC, Ambrose NS. Outcome after surgery for perianal fistula: predictive value of MR imaging. AJR Am J Roentgenol. 1998;171(2):403–6. doi:10.2214/ajr.171.2.9694464.

    Article  CAS  PubMed  Google Scholar 

  87. Schwartz DA, Wiersema MJ, Dudiak KM, et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas. Gastroenterology. 2001;121(5):1064–72.

    Article  CAS  PubMed  Google Scholar 

  88. Skalej M, Makowiec F, Weinlich M, Jenss H, Laniado M, Starlinger M. Magnetic resonance imaging in perianal Crohn’s disease. Dtsch Med Wochenschr. 1993;118(49):1791–6. doi:10.1055/s-2008-1059515.

    Article  CAS  PubMed  Google Scholar 

  89. Koelbel G, Schmiedl U, Majer MC, et al. Diagnosis of fistulae and sinus tracts in patients with Crohn disease: value of MR imaging. AJR Am J Roentgenol. 1989;152(5):999–1003. doi:10.2214/ajr.152.5.999.

    Article  CAS  PubMed  Google Scholar 

  90. Scholefield JH, Berry DP, Armitage NC, Wastie ML. Magnetic resonance imaging in the management of fistula in ano. Int J Colorectal Dis. 1997;12(5):276–9.

    Article  CAS  PubMed  Google Scholar 

  91. Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med. 1999;340(18):1398–405. doi:10.1056/NEJM199905063401804.

    Article  CAS  PubMed  Google Scholar 

  92. Horsthuis K, Ziech MLW, Bipat S, et al. Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn’s disease. Clin Imaging. 2011;35(5):360–5. doi:10.1016/j.clinimag.2010.09.003.

    Article  PubMed  Google Scholar 

  93. Tozer P, Ng SC, Siddiqui MR, et al. Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn’s perianal fistulas. Inflamm Bowel Dis. 2012;18(10):1825–34. doi:10.1002/ibd.21940.

    Article  PubMed  Google Scholar 

  94. Irvine EJ. Usual therapy improves perianal Crohn’s disease as measured by a new disease activity index. McMaster IBD Study Group. J Clin Gastroenterol. 1995;20(1):27–32. doi:10.1007/BF02053756.

    Article  CAS  PubMed  Google Scholar 

  95. Bell SJ, Williams AB, Wiesel P, Wilkinson K, Cohen RCG, Kamm MA. The clinical course of fistulating Crohn’s disease. Aliment Pharmacol Ther. 2003;17(9):1145–51.

    Article  CAS  PubMed  Google Scholar 

  96. Dewint P, Hansen BE, Verhey E, et al. Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn’s disease: a randomised, double-blind, placebo controlled trial (ADAFI). Gut. 2014;63(2):292–9. doi:10.1136/gutjnl-2013-304488.

    Article  CAS  PubMed  Google Scholar 

  97. Freire P, Portela F, Donato MM, Ferreira M, Andrade P, Sofia C. CARD15 mutations and perianal fistulating Crohn’s disease: correlation and predictive value of antibiotic response. Dig Dis Sci. 2011;56(3):853–9. doi:10.1007/s10620-010-1331-1.

    Article  CAS  PubMed  Google Scholar 

  98. Jones JL, Kaplan GG, Peyrin-Biroulet L, et al. Effects of concomitant immunomodulator therapy on efficacy and safety of anti-tumor necrosis factor therapy for Crohn’s disease: a meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol. 2015;13(13):2233–2240.e2. doi:10.1016/j.cgh.2015.06.034.

  99. Ford AC, Sandborn WJ, Khan KJ, Hanauer SB, Talley NJ, Moayyedi P. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):644–59. quiz 660 doi:10.1038/ajg.2011.73.

    Article  CAS  PubMed  Google Scholar 

  100. Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med. 2004;350(9):876–85. doi:10.1056/NEJMoa030815.

    Article  CAS  PubMed  Google Scholar 

  101. Lichtenstein GR, Yan S, Bala M, Blank M, Sands BE. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn’s disease. Gastroenterology. 2005;128(4):862–9.

    Article  CAS  PubMed  Google Scholar 

  102. Ng SC, Plamondon S, Gupta A, Burling D, Kamm MA. Prospective assessment of the effect on quality of life of anti-tumour necrosis factor therapy for perineal Crohn’s fistulas. Aliment Pharmacol Ther. 2009;30(7):757–66. doi:10.1111/j.1365-2036.2009.04088.x.

    Article  CAS  PubMed  Google Scholar 

  103. Regueiro M, Mardini H. Treatment of perianal fistulizing Crohn’s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis. 2003;9(2):98–103.

    Article  PubMed  Google Scholar 

  104. Kotze PG, Albuquerque IC, da Luz Moreira A, Tonini WB, Olandoski M, CSR C. Perianal complete remission with combined therapy (seton placement and anti-TNF agents) in Crohn’s disease: a Brazilian multicenter observational study. Arq Gastroenterol. 2014;51(4):284–9. doi:10.1590/S0004-28032014000400004.

    Article  PubMed  Google Scholar 

  105. van der Hagen SJ, Baeten CG, Soeters PB, Russel MGVM, Beets-Tan RG, van Gemert WG. Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn’s disease: a preliminary report. Dis Colon Rectum. 2005;48(4):758–67. doi:10.1007/s10350-004-0828-0.

    Article  PubMed  Google Scholar 

  106. Roumeguère P, Bouchard D, Pigot F, et al. Combined approach with infliximab, surgery, and methotrexate in severe fistulizing anoperineal Crohn’s disease: results from a prospective study. Inflamm Bowel Dis. 2011;17(1):69–76. doi:10.1002/ibd.21405.

    Article  PubMed  Google Scholar 

  107. Higashi D, Futami K, Egawa Y, et al. Infliximab treatment for anal fistula in patients with Crohn’s disease. Anticancer Res. 2009;29(3):927–33.

    PubMed  Google Scholar 

  108. Louis E, Mary J-Y, Vernier-Massouille G, et al. Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology. 2012;142(1):63–70.e5; quiz e31. doi:10.1053/j.gastro.2011.09.034.

  109. Yanai H, Lichtenstein L, Assa A, et al. Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab. Clin Gastroenterol Hepatol. 2015;13(3):522–530.e2. doi:10.1016/j.cgh.2014.07.029.

  110. Van Assche G, Vermeire S, Ballet V, et al. Switch to adalimumab in patients with Crohn’s disease controlled by maintenance infliximab: prospective randomised SWITCH trial. Gut. 2012;61(2):229–34. doi:10.1136/gutjnl-2011-300755.

    Article  PubMed  CAS  Google Scholar 

  111. Colombel J, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn’s disease: the CHARM trial. Gastroenterology. 2007;132(1):52–65. doi:10.1053/j.gastro.2006.11.041.

    Article  CAS  PubMed  Google Scholar 

  112. Colombel J-F, Schwartz DA, Sandborn WJ, et al. Adalimumab for the treatment of fistulas in patients with Crohn’s disease. Gut. 2009;58(7):940–8. doi:10.1136/gut.2008.159251.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Sandborn WJ, Rutgeerts P, Enns R, et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med. 2007;146(12):829–38.

    Article  PubMed  Google Scholar 

  114. Lichtiger S, Binion DG, Wolf DC, et al. The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn’s disease who failed prior infliximab therapy. Aliment Pharmacol Ther. 2010;32(10):1228–39. doi:10.1111/j.1365-2036.2010.04466.x.

    Article  CAS  PubMed  Google Scholar 

  115. Echarri A, Castro J, Barreiro M, Carpio D, Pereira S, Lorenzo A. Evaluation of adalimumab therapy in multidisciplinary strategy for perianal Crohn’s disease patients with infliximab failure. J Crohns Colitis. 2010;4(6):654–60. doi:10.1016/j.crohns.2010.07.012.

    Article  PubMed  Google Scholar 

  116. Schreiber S, Lawrance IC, Thomsen OØ, Hanauer SB, Bloomfield R, Sandborn WJ. Randomised clinical trial: certolizumab pegol for fistulas in Crohn’s disease – subgroup results from a placebo-controlled study. Aliment Pharmacol Ther. 2011;33(2):185–93. doi:10.1111/j.1365-2036.2010.04509.x.

    Article  CAS  PubMed  Google Scholar 

  117. White RA, Eisenstat TE, Rubin RJ, Salvati EP. Seton management of complex anorectal fistulas in patients with Crohn’s disease. Dis Colon Rectum. 1990;33(7):587–9.

    Article  CAS  PubMed  Google Scholar 

  118. Williams JG, Rothenberger DA, Nemer FD, Goldberg SM. Fistula-in-ano in Crohn’s disease. Results of aggressive surgical treatment. Dis Colon Rectum. 1991;34(5):378–84.

    Article  CAS  PubMed  Google Scholar 

  119. Hyder SA, Travis SPL, Jewell DP, McC Mortensen NJ, George BD. Fistulating anal Crohn’s disease: results of combined surgical and infliximab treatment. Dis Colon Rectum. 2006;49(12):1837–41. doi:10.1007/s10350-006-0656-5.

    Article  PubMed  Google Scholar 

  120. Tanaka S, Matsuo K, Sasaki T, et al. Clinical advantages of combined seton placement and infliximab maintenance therapy for perianal fistulizing Crohn’s disease: when and how were the seton drains removed? Hepatogastroenterology. 2010;57(97):3–7.

    CAS  PubMed  Google Scholar 

  121. de Groof EJ, Buskens CJ, Ponsioen CY, et al. Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial. Trials. 2015;16:366. doi:10.1186/s13063-015-0831-x.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  122. Vitton V, Gasmi M, Barthet M, Desjeux A, Orsoni P, Grimaud JC. Long-term healing of Crohn’s anal fistulas with fibrin glue injection. Aliment Pharmacol Ther. 2005;21(12):1453–7. doi:10.1111/j.1365-2036.2005.02456.x.

    Article  CAS  PubMed  Google Scholar 

  123. O’Riordan JM, Datta I, Johnston C, Baxter NN. A systematic review of the anal fistula plug for patients with Crohn’s and non-Crohn’s related fistula-in-ano. Dis Colon Rectum. 2012;55(3):351–8. doi:10.1097/DCR.0b013e318239d1e4.

    Article  PubMed  Google Scholar 

  124. Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009;52(1):79–86. doi:10.1007/DCR.0b013e3181973487.

    Article  PubMed  Google Scholar 

  125. Makowiec F, Jehle EC, Becker HD, Starlinger M. Clinical course after transanal advancement flap repair of perianal fistula in patients with Crohn’s disease. Br J Surg. 1995;82(5):603–6.

    Article  CAS  PubMed  Google Scholar 

  126. Soltani A, Kaiser AM. Endorectal advancement flap for cryptoglandular or Crohn’s fistula-in-ano. Dis Colon Rectum. 2010;53(4):486–95. doi:10.1007/DCR.0b013e3181ce8b01.

    Article  PubMed  Google Scholar 

  127. Gingold DS, Murrell ZA, Fleshner PR. A prospective evaluation of the ligation of the intersphincteric tract procedure for complex anal fistula in patients with Crohn’s disease. Ann Surg. 2014;260(6):1057–61. doi:10.1097/SLA.0000000000000479.

    Article  PubMed  Google Scholar 

  128. de la Portilla F, Alba F, García-Olmo D, Herrerías JM, González FX, Galindo A. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis. 2013;28(3):313–23. doi:10.1007/s00384-012-1581-9.

    Article  PubMed  Google Scholar 

  129. Lee WY, Park KJ, Cho YB, et al. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn’s fistula. Stem Cells. 2013;31(11):2575–81. doi:10.1002/stem.1357.

    Article  CAS  PubMed  Google Scholar 

  130. Cho YB, Park KJ, Yoon SN, et al. Long-term results of adipose-derived stem cell therapy for the treatment of Crohn’s fistula. Stem Cells Transl Med. 2015;4(5):532–7. doi:10.5966/sctm.2014-0199.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Ciccocioppo R, Gallia A, Sgarella A, Kruzliak P, Gobbi PG, Corazza GR. Long-term follow-up of Crohn disease fistulas after local injections of bone marrow-derived mesenchymal stem cells. Mayo Clin Proc. 2015;90(6):747–55. doi:10.1016/j.mayocp.2015.03.023.

    Article  PubMed  Google Scholar 

  132. Singh S, Ding NS, Mathis KL, et al. Systematic review with meta-analysis: faecal diversion for management of perianal Crohn’s disease. Aliment Pharmacol Ther. 2015;42(7):783–92. doi:10.1111/apt.13356.

    Article  CAS  PubMed  Google Scholar 

  133. Yamamoto T, Bain IM, Allan RN, Keighley MR. Persistent perineal sinus after proctocolectomy for Crohn’s disease. Dis Colon Rectum. 1999;42(1):96–101.

    Article  CAS  PubMed  Google Scholar 

  134. Schwandner O. Video-assisted anal fistula treatment (VAAFT) combined with advancement flap repair in Crohn’s disease. Tech Coloproctol. 2013;17(2):221–5. doi:10.1007/s10151-012-0921-7.

    Article  CAS  PubMed  Google Scholar 

  135. Bourikas LA, Koutroubakis IE. Anti-TNF and fistulizing perianal Crohn’s disease: use in clinical practice. Curr Drug Targets. 2010;11(2):187–97.

    Article  CAS  PubMed  Google Scholar 

  136. Karmiris K, Bielen D, Vanbeckevoort D, et al. Long-term monitoring of infliximab therapy for perianal fistulizing Crohn’s disease by using magnetic resonance imaging. Clin Gastroenterol Hepatol. 2011;9(2):130–6. doi:10.1016/j.cgh.2010.10.022.

    Article  CAS  PubMed  Google Scholar 

  137. Bode M, Eder S, Schürmann G. Perianal fistulas in Crohn’s disease—biologicals and surgery: is it worthwhile? Z Gastroenterol. 2008;46(12):1376–83. doi:10.1055/s-2008-1027626.

    Article  CAS  PubMed  Google Scholar 

  138. El-Gazzaz G, Hull T, Church JM. Biological immunomodulators improve the healing rate in surgically treated perianal Crohn’s fistulas. Colorectal Dis. 2012;14(10):1217–23. doi:10.1111/j.1463-1318.2012.02944.x.

    Article  CAS  PubMed  Google Scholar 

  139. Levien DH, Surrell J, Mazier WP. Surgical treatment of anorectal fistula in patients with Crohn’s disease. Surg Gynecol Obstet. 1989;169(2):133–6.

    CAS  PubMed  Google Scholar 

  140. Radcliffe AG, Ritchie JK, Hawley PR, Lennard-Jones JE, Northover JM. Anovaginal and rectovaginal fistulas in Crohn’s disease. Dis Colon Rectum. 1988;31(2):94–9.

    Article  CAS  PubMed  Google Scholar 

  141. Frizelle FA, Santoro GA, Pemberton JH. The management of perianal Crohn’s disease. Int J Colorectal Dis. 1996;11(5):227–37.

    Article  CAS  PubMed  Google Scholar 

  142. Gyde SN, Prior P, Macartney JC, Thompson H, Waterhouse JA, Allan RN. Malignancy in Crohn’s disease. Gut. 1980;21(12):1024–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  143. Givel JC, Hawker P, Allan RN, Alexander-Williams J. Enterovaginal fistulas associated with Crohn’s disease. Surg Gynecol Obstet. 1982;155(4):494–6.

    CAS  PubMed  Google Scholar 

  144. Valente MA. Contemporary surgical management of rectovaginal fistula in Crohn’s disease. World J Gastrointest Pathophysiol. 2014;5(4):487. doi:10.4291/wjgp.v5.i4.487.

    Article  PubMed  PubMed Central  Google Scholar 

  145. Sands BE, Blank MA, Patel K, van Deventer SJ. Long-term treatment of rectovaginal fistulas in Crohn’s disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol. 2004;2(10):912–20.

    Article  CAS  PubMed  Google Scholar 

  146. Songne K, Scotté M, Lubrano J, et al. Treatment of anovaginal or rectovaginal fistulas with modified Martius graft. Colorectal Dis. 2007;9(7):653–6. doi:10.1111/j.1463-1318.2007.01232.x.

    Article  CAS  PubMed  Google Scholar 

  147. Andreani SM, Dang HH, Grondona P, Khan AZ, Edwards DP. Rectovaginal fistula in Crohn’s disease. Dis Colon Rectum. 2007;50(12):2215–22. doi:10.1007/s10350-007-9057-7.

    Article  CAS  PubMed  Google Scholar 

  148. O’Leary DP, Milroy CE, Durdey P. Definitive repair of anovaginal fistula in Crohn’s disease. Ann R Coll Surg Engl. 1998;80(4):250–2.

    PubMed  PubMed Central  Google Scholar 

  149. Hull TL, Fazio VW. Surgical approaches to low anovaginal fistula in Crohn’s disease. Am J Surg. 1997;173(2):95–8. doi:10.1016/S0002-9610(96)00420-5.

    Article  CAS  PubMed  Google Scholar 

  150. Hesterberg R, Schmidt WU, Müller F, Röher HD. Treatment of anovaginal fistulas with an anocutaneous flap in patients with Crohn’s disease. Int J Colorectal Dis. 1993;8(1):51–4.

    Article  CAS  PubMed  Google Scholar 

  151. Robertson WG, Mangione JS. Cutaneous advancement flap closure: alternative method for treatment of complicated anal fistulas. Dis Colon Rectum. 1998;41(7):884–6. discussion 886–7

    Article  CAS  PubMed  Google Scholar 

  152. Simmang CL, Lacey SW, Huber PJ. Rectal sleeve advancement: repair of rectovaginal fistula associated with anorectal stricture in Crohn’s disease. Dis Colon Rectum. 1998;41(6):787–9.

    Article  CAS  PubMed  Google Scholar 

  153. Lee PY, Fazio VW, Church JM, Hull TL, Eu KW, Lavery IC. Vaginal fistula following restorative proctocolectomy. Dis Colon Rectum. 1997;40(7):752–9.

    Article  CAS  PubMed  Google Scholar 

  154. Hatch Q, Champagne BJ, Maykel JA, et al. The impact of pregnancy on surgical Crohn disease: an analysis of the Nationwide Inpatient Sample. J Surg Res. 2014;190(1):41–6. doi:10.1016/j.jss.2014.03.028.

    Article  PubMed  Google Scholar 

  155. Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut. 2006;55(Suppl 1):i36–58. doi:10.1136/gut.2005.081950c.

    Article  PubMed  PubMed Central  Google Scholar 

  156. Pikarsky AJ, Gervaz P, Wexner SD. Perianal Crohn disease: a new scoring system to evaluate and predict outcome of surgical intervention. Arch Surg. 2002;137(7):774–7. discussion 778

    Article  PubMed  Google Scholar 

  157. Safar B, Sands D. Perianal Crohn’s disease. Clin Colon Rectal Surg. 2007;20(4):282–93. doi:10.1055/s-2007-991027.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36(1):77–97. doi:10.1007/BF02050307.

    Article  CAS  PubMed  Google Scholar 

  159. Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med. 1980;302(18):981–7. doi:10.1056/NEJM198005013021801.

    Article  CAS  PubMed  Google Scholar 

  160. Allan A, Linares L, Spooner HA, Alexander-Williams J. Clinical index to quantitate symptoms of perianal Crohn’s disease. Dis Colon Rectum. 1992;35(7):656–61.

    Article  CAS  PubMed  Google Scholar 

  161. Yassin NA, Askari A, Warusavitarne J, et al. Systematic review: the combined surgical and medical treatment of fistulising perianal Crohn’s disease. Aliment Pharmacol Ther. 2014;40(August):741–9. doi:10.1111/apt.12906.

    Article  CAS  PubMed  Google Scholar 

  162. Gu J, Valente MA, Remzi FH, Stocchi L. Factors affecting the fate of faecal diversion in patients with perianal Crohn’s disease. Colorectal Dis. 2015;17(1):66–72. doi:10.1111/codi.12796.

    Article  CAS  PubMed  Google Scholar 

  163. Régimbeau JM, Panis Y, Cazaban L, et al. Long-term results of faecal diversion for refractory perianal Crohn’s disease. Colorectal Dis. 2001;3:232–7. doi:10.1046/j.1463-1318.2001.00250.x.

    Article  PubMed  Google Scholar 

  164. Hong MK, Craig Lynch A, Bell S, et al. Faecal diversion in the management of perianal Crohn’s disease. Colorectal Dis. 2011;13(2):171–6. doi:10.1111/j.1463-1318.2009.02092.x.

    Article  CAS  PubMed  Google Scholar 

  165. Makowiec F, Jehle EC, Starlinger M. Clinical course of perianal fistulas in Crohn’s disease. Gut. 1995;37(5):696–701. doi:10.1136/gut.37.5.696.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Adegbola, S.O., Sahnan, K., Tozer, P.J., Faiz, O., Hart, A. (2017). Management of Perianal Crohn’s Disease in the Biologic Era. In: Beynon, J., Harris, D., Davies, M., Evans, M. (eds) Coloproctology. Springer, Cham. https://doi.org/10.1007/978-3-319-55957-5_1

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