Store-Operated Calcium Entry: An Historical Overview

  • James W. PutneyEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 981)


Store-operated calcium entry is a mechanism of Ca2+ signaling that has evolved from theory to molecules over a period of 30 years. This brief overview summarizes the major milestones that have led to the current concepts regarding the mechanisms and regulation of this most widely encountered of calcium signaling mechanisms.


Calcium signaling Calcium channels Store-operated channels Intracellular calcium stores Signaling mechanisms History 


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Authors and Affiliations

  1. 1.Scientist Emeritus, National Institute of Environmental Health Sciences – NIHResearch Triangle ParkUSA

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