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The Endoplasmic Reticulum and the Cellular Reticular Network

  • Luis B. Agellon
  • Marek Michalak
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 981)

Abstract

The endoplasmic reticulum and the other organelles of the eukaryotic cell are membrane-bound structures that carry out specialized functions. In this chapter, we discuss strategies that the cell has adopted to link and coordinate the different activities occurring within its various organelles as the cell carries out its physiological role.

Keywords

Calcium signaling Cell stress Cellular reticular network Homeostasis Membrane contact sites 

Abbreviations

ATF6

activating transcription factor 6

BiP

immunoglobulin binding protein

ER

endoplasmic reticulum

ERAD

ER-associated degradation

ERMAS

ER-mitochondria encounter structure

GRP

glucose regulated protein

HSP

heat shock protein

InsP3

inositol-1,4,5-trisphosphate

IRE

serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme

ORAI

Ca2+ release-activated Ca2+ channel

PERK

dsRNA-activated protein kinase-like ER kinase

PDI

protein disulfide isomerase

RER

rough ER

SARAF

SOCE-associated regulatory factor

SCAP

SREBP cleavage activating protein

SER

smooth ER

SERCA

sarcoplasmic/endoplasmic reticulum Ca2+-ATPase

SOCE

store-operated Ca2+ entry

SR

sarcoplasmic reticulum

SREBP

sterol-response element-binding protein

STIM

stromal-interacting molecule

RyR

ryanodine receptor

UPR

unfolded protein response

Xbp1

X-box binding protein 1

Notes

Acknowledgements

Research in our laboratories is supported by grants from the Canadian Institutes of Health Research grants MOP-15291, MOP-15415, MOP-86750 and PS-153325.

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.School of Human NutritionMcGill UniversitySte. Anne de BellevueCanada
  2. 2.Department of BiochemistryUniversity of AlbertaEdmontonCanada

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