Novel Biomarkers at Risk Stratification of Diabetes Mellitus Patients

Part of the Stem Cells in Clinical Applications book series (SCCA)


Type 2 diabetes mellitus (T2DM) remains a leading cause of cardiovascular (CV) events and diseases worldwide. There is large body of evidence regarding use of the cardiac biomarkers to risk stratification at higher CV risk individuals who belong to general population and cohort with established CV disease. Although T2DM patients have higher incidence of macrovascular and microvascular CV complications than the general population, whether cardiac biomarkers would be effective to risk stratification of the T2DM is not fully understood. The chapter is dedicated to the summary of our knowledge regarding clinical implementation of the biomarker-based strategy of the CV risk assessment in T2DM patient population. The role of natriuretic peptides, galectin-3, solubilized ST, asymmetric dimethylarginine, interleukins, growth differentiation factor-15, as well as biomarkers of endothelial dysfunction are widely discussed.


Diabetes mellitus Cardiovascular disease Risk Biomarkers Prediction Mortality 



Coronary artery disease




Growth differentiation factor-15


Glycated hemoglobin


High-sensitivity C-reactive protein


High-sensitivity cardiac troponin T


Impaired fasting glucose


Impaired glucose tolerance




Natriuretic peptides


A member of the interleukin-1 receptor family protein of tumorigenicity


Type 2 diabetes mellitus


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Cardiology Unit, Internal Medicine DepartmentState Medical UniversityZaporozhyeUkraine

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