Abstract
Histologically, skeletal muscle cells are distinguished by eosinophilic cytoplasm containing light and dark striations that correspond to the alternating arrangement of thin and thick myofilaments (Fig. 8. 1). These cells can be seen in varying degrees in soft tissue tumors with skeletal muscle differentiation. However, in tumors that are poorly differentiated, rhabdomyoblastic differentiation must sometimes be confirmed by immunohistochemical stains for skeletal muscle markers (e.g., myogenin) [1].
References
Cessna MH, Zhou H, Perkins SL, Tripp SR, Layfield L, Daines C, et al. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol. 2001;25(9):1150–7.
De Rosa G, De Carolis MP, Pardeo M, Bersani I, Tempera A, De Nisco A, et al. Neonatal emergencies associated with cardiac rhabdomyomas: an 8-year experience. Fetal Diagn Ther. 2011;29(2):169–77.
Burke AP, Virmani R. Cardiac rhabdomyoma: a clinicopathologic study. Mod Pathol. 1991;4(1):70–4.
Kapadia SB, Meis JM, Frisman DM, Ellis GL, Heffner DK, Hyams VJ. Adult rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study. Hum Pathol. 1993;24(6):608–17.
Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, et al. Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia. 2008;23(2):202–4.
Goldblum J, Weiss S, Folpe AL, editors. Enzinger and Weiss’s soft tissue tumors. 6th ed. Philadelphia: Elsevier; 2013.
Kapadia SB, Meis JM, Frisman DM, Ellis GL, Heffner DK. Fetal rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study of 24 cases. Hum Pathol. 1993;24(7):754–65.
DiSanto S, Abt AB, Boal DK, Krummel TM. Fetal rhabdomyoma and nevoid basal cell carcinoma syndrome. Pediatr Pathol. 1992;12(3):441–7.
Hornick JL, editor. Practical soft tissue pathology: a diagnostic approach. 1st ed. Philadelphia: Saunders; 2013.
Fesslova V, Villa L, Rizzuti T, Mastrangelo M, Mosca F. Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally. Prenat Diagn. 2004;24(4):241–8.
Ognjanovic S, Linabery AM, Charbonneau B, Ross JA. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975–2005. Cancer. 2009;115(18):4218–26.
Newton Jr WA, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, et al. Histopathology of childhood sarcomas, intergroup rhabdomyosarcoma studies I and II: clinicopathologic correlation. J Clin Oncol. 1988;6(1):67–75.
Miettinen M, editor. Modern soft tisssue pathology: tumors and non-neoplastic conditions. 1st ed. New York: Cambridge University Press; 2010.
Newton Jr WA, Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, et al. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification – an intergroup rhabdomyosarcoma study. Cancer. 1995;76(6):1073–85.
Fletcher CDM, Bridge JA, Hogendoorn PC, Mertens F, editors. Pathology and genetics of tumours of soft tissue and bone. 4th ed. Lyon: World Health Organization; 2013.
Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, et al. Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's oncology group. Am J Surg Pathol. 2007;31(6):895–901.
Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children’s oncology group. J Clin Oncol. 2002;20(11):2672–9.
Gaffney EF, Dervan PA, Fletcher CD. Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol. 1993;17(6):601–9.
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Perry, K. (2017). Skeletal Muscle Tumors. In: Soft Tissue Pathology for Clinicians. Pathology for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-319-55654-3_8
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