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Diffuse Low-Grade Gliomas in Adults pp 627–635Cite as

Emerging Therapies for Diffuse Low Grade Glioma

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Abstract

Because of the intractable nature of diffuse low grade gliomas, which always progress into higher grade, malignant gliomas, there is increased interest in the use of newer and alternative approaches in addition to conventional approached including surgery, chemotherapy, and radiotherapy. These emerging treatments include several technologies for thermal ablation and improved drug delivery as well as immunotherapy and nutritional or “alternative” therapies.

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References

  1. Missios S, Belekis K, Barnett GH. Renaissance of laser interstitial thermotherapy. Neurosurg Focus. 2015;38(3):E13:1–10.

    Article  Google Scholar 

  2. Carpentier A, McNichols RJ, Staffort RJ, et al. Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors. Neurosurgery. 2008;63(Suppl 1):ONS21–9.

    PubMed  Google Scholar 

  3. Sloan AE, Ahluwalia MS, Valerio-Pascua J, et al. Results of the NeuroBlate System first-in-humans Phase I clinical trials for recurrent glioblastoma. J Neurosurg. 2013;118:1202–19.

    Article  PubMed  Google Scholar 

  4. Ronkainen J, Sequeiros RB, Tervonen O. Cost comparison of low field (0.23T) MRI-guided laser ablation and surgery. Eur Radiol. 2006;16:2858–65.

    Article  CAS  PubMed  Google Scholar 

  5. Ascher PW, Justich E, Schröttner O. A new surgical but less invasive treatment of central brain tumours preliminary report. Acta Neurochir Suppl (Wien). 1991;52:78–80.

    Article  CAS  Google Scholar 

  6. Kahn T, Bettag M, Ulrich F, Schwarzmaier HJ, Schober R, Fürst G, Mödder U. MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms. J Comput Assist Tomogr. 1994;18(4):519–32.

    Article  CAS  PubMed  Google Scholar 

  7. Leonardi MA, Lumenta CB, Gumprecht HK, von Einsiedel GH, Wilhelm T. Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR-unit. Minim Invasive Neurosurg. 2001;44(1):37–42.

    Article  CAS  PubMed  Google Scholar 

  8. Roux FX, Merienne L, Fallet-Bianco C, et al. Stereotactic laser interstitial thermotherapy: a new alternative in the therapeutic management of some brain tumors. Neurochirurgie. 1992;38:238–44.

    CAS  PubMed  Google Scholar 

  9. Tovar-Spinoza Z, Choi H. MRI-guided laser interstitial thermal therapy for the treatment of low-grade gliomas in children: a case-series review, description of the current technologies and perspectives. Childs Nerv Syst. 2016;32(10):1947–56. doi:10.1007/s00381-016-3193-0.

    Article  PubMed  Google Scholar 

  10. Barnett GH, Chen C, Gross RE, Sloan AE. Laser ablation techniques. Neurosurg Focus. 2016;41(4):E1.

    Article  PubMed  Google Scholar 

  11. Buttric S, Komitar RJ. Laser interstitial thermotherapy. Neurosurgery. 2016;79(Suppl 1):S1–91.

    Article  Google Scholar 

  12. Koivukangas J, Koivukangas P. Treatment of low-grade cerebral astrocytoma: new methods and evaluation of results. Ann Clin Res. 1986;18(Suppl 47):115–24.

    PubMed  Google Scholar 

  13. Guthkelch AN, Carter LP, Cassady JR, Hynynen KH, Iacono RP, Johnson PC, Obbens EA, Roemer RB, Seeger JF, Shimm DS, et al. Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial. J Neuro-Oncol. 1991;10(3):271–84.

    Article  CAS  Google Scholar 

  14. D'Amico RS, Kennedy BC, Bruce JN. Neurosurgical oncology: advances in operative technologies and adjuncts. J Neuro-Oncol. 2014;119(3):451–63. doi:10.1007/s11060-014-1493-3. Review

    Article  Google Scholar 

  15. Ram Z, Cohen ZR, Harnof S, Tal S, Faibel M, Nass D, Maier SE, Hadani M, Mardor Y. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery. 2006;59(5):949–55. discussion 955–6

    PubMed  Google Scholar 

  16. Monteith S, Sheehan J, Medel R, Wintermark M, Eames M, Snell J, Kassell NF, Elias WJ. Potential intracranial applications of magnetic resonance-guided focused ultrasound surgery. J Neurosurg. 2013;118(2):215–21. doi:10.3171/2012.10.JNS12449. Review

    Article  PubMed  Google Scholar 

  17. McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery. 2010;66(2):323–32. discussion 332 doi:10.1227/01.NEU.0000360379.95800.2F.

    Article  PubMed  PubMed Central  Google Scholar 

  18. http://www.fusfoundation.org/diseases-and-conditions/neurological/brain-tumor.

  19. http://www.fusfoundation.org/diseases-and-conditions/overview.

  20. Mirza AN, Fornage BD, Sneige N, Kuerer HM, Newman LA, Ames FC, Singletary SE. Radiofrequency ablation of solid tumors. Cancer J. 2001;7(2):95–102. Review

    CAS  PubMed  Google Scholar 

  21. Parrent AG. Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report. J Neurosurg. 1999;91(5):881–4.

    Article  CAS  PubMed  Google Scholar 

  22. Gananadha S, Wulf S, Morris DL. Safety and efficacy of radiofrequency ablation of brain: a potentially minimally invasive treatment for brain tumours. Minim Invasive Neurosurg. 2004;47(6):325–8.

    Article  CAS  PubMed  Google Scholar 

  23. Merkle EM, Shonk JR, Zheng L, Duerk JL, Lewin JS. MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2 T. Eur Radiol. 2001;11(5):884–92.

    Article  CAS  PubMed  Google Scholar 

  24. Gründer W, Goldammer A, Schober R, Vitzthum HE. Cryotherapy of the brain—a new methodologic approach. Z Med Phys. 2003;13(3):203–7. German

    Article  PubMed  Google Scholar 

  25. Tacke J, Speetzen R, Adam G, Sellhaus B, Glowinski A, Heschel I, Schäffter T, Schorn R, Grosskortenhaus S, Rau G, Günther RW. Experimental MR imaging-guided interstitial cryotherapy of the brain. AJNR Am J Neuroradiol. 2001;22(3):431–40.

    CAS  PubMed  Google Scholar 

  26. Li M, Cui Y, Li X, Guo Y, Wang B, Zhang J, Xu J, Han S, Shi X. Functional changes of dendritic cells in C6 glioma-bearing rats that underwent combined argon-helium cryotherapy and IL-12 treatment. Technol Cancer Res Treat. 2016;15(4):618–24. doi:10.1177/1533034615606322.

    Article  PubMed  Google Scholar 

  27. Wang H, Tu HJ, Qin J, Li XJ, Huang KM, Zhou ZM, Wang LC. Effect of cryotherapy and 5-fluorouracil on apoptosis of G422 glioma cells. Ai Zheng. 2004;23(4):412–5. Chinese

    CAS  PubMed  Google Scholar 

  28. Naidoo J, Panday H, Jackson S, Grossman SA. Optimizing the delivery of antineoplastic therapies to the central nervous system. Oncology (Williston Park). 2016;30(11)

    Google Scholar 

  29. Bobo RH, et al. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A. 1994;91:2076–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Jahangiri A, Chin AT, Flanigan PM, Chen R, Bankiewicz K, Aghi MK. Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies. J Neurosurg. 2016;1:1–10.

    Google Scholar 

  31. Ursu R, Carpentier A, Metellus P, Barrie M, Meng Y, Laigle-Donadey F, Tibi A, Chinot O, Carpentier AF. Phase II trial of intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma. J Clin Oncol. 2009;27(15_suppl):2043.

    Google Scholar 

  32. Kunwar S, Chang S, Westphal M, et al. Phase III randomized trial of CED of IL13-PEPE38QQR vs gliadel wafers for recurrent GBM. Neuro-Oncology. 2010;12:871–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Zhou Z, Singh R, Souweidane MM. Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment. Curr Neuropharmacol. 2017;15(1):116–128. PubMed PMID: 27306036; PubMed Central PMCID: PMC5327456.

    Google Scholar 

  34. Bruce JN, Fine RL, Canoll P, Yun J, Kennedy BC, Rosenfeld SS, Sands SA, Surapaneni K, Lai R, Yanes CL, Bagiella E, DeLaPaz RL. Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan. Neurosurgery. 2011;69(6):1272–9. discussion 1279-80 doi:10.1227/NEU.0b013e3182233e24.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Newman WC, Amankulor NA. Focused ultrasound enhances CNS system delivery. Neurosurgery. 2016;79(6):N12.

    Article  PubMed  Google Scholar 

  36. Leuthardt EC, Duan C, Kim MJ, Campian JL, Kim AH, Miller-Thomas MM, Shimony JS, Tran DD. Hyperthermic laser ablation of recurrent glioblastoma leads to temporary disruption of the peritumoral blood brain barrier. PLoS One. 2016;11(2):e0148613. doi:10.1371/journal.pone.0148613.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Rodriguez A, Tatter SB. Laser ablation of recurrent malignant gliomas: current status and future perspective. Neurosurgery. 2016;79(Suppl 1):S35–9.

    Article  PubMed  Google Scholar 

  38. Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res. 2014;20(22):5620–9. doi:10.1158/1078-0432.CCR-14-0832. Review

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Sloan AE, Okada H, Ryken TC, Kalkanis SN, Olson JJ. The role of emerging therapy in the management of patients with diffuse low grade glioma. J Neuro-Oncol. 2015;125(3):631–5. doi:10.1007/s11060-015-1865-3. Review

    Article  CAS  Google Scholar 

  40. Okada H, Butterfield LH, Hamilton RL, Hoji A, Sakaki M, Ahn BJ, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively MO, Chan MD, Salazar AM, Shaw EG, Potter DM, Lieberman FS. Induction of robust type-I CD8+ T-cell responses in WHO grade 2 low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC. Clin Cancer Res. 2015;21(2):286–94. doi:10.1158/1078-0432.CCR-14-1790.

    Article  CAS  PubMed  Google Scholar 

  41. Pluhar GE, Grogan PT, Seiler C, Goulart M, Santacruz KS, Carlson C, Chen W, Olin MR, Lowenstein PR, Castro MG, Haines SJ, Ohlfest JR. Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine. 2010;28(19):3371–8. doi:10.1016/j.vaccine.2010.02.082.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Normolle DP, Connelly AK, Dibridge S, Mason G, Whiteside TL, Okada H. Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas. Neuro-Oncology. 2016;18(8):1157–68. doi:10.1093/neuonc/now026.

    Article  PubMed  Google Scholar 

  43. Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Potter DM, Connelly AK, Dibridge SA, Whiteside TL, Okada H. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol. 2014;32(19):2050–8. doi:10.1200/JCO.2013.54.0526.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Woolf EC, Syed N, Scheck AC. Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy. Front Mol Neurosci. 2016;9:122. Review

    Article  PubMed  PubMed Central  Google Scholar 

  45. Chaichana KL, McGirt MJ, Woodworth GF, Datoo G, Tamargo RJ, Weingart J, Olivi A, Brem H, Quinones-Hinojosa A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurol Res. 2010;32(4):442–8. doi:10.1179/174313209X431101. Epub 2009 Jul 8. PubMed PMID: 19589201.

  46. DeLorenze GN, McCoy L, Tsai AL, Quesenberry CP Jr, Rice T, Il’yasova D, Wrensch M. Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma. BMC Cancer. 2010 May 19;10:215. doi:10.1186/1471-2407-10-215. PubMed PMID: 20482871; PubMed Central PMCID: PMC2880992.

  47. Heese O, Schmidt M, Nickel S, Berger H, Goldbrunner R, Tonn JC, Bähr O, Steinbach JP, Simon M, Schramm J, Krex D, Schackert G, Reithmeier T, Nikkhah G, Löffler M, Weller M, Westphal M; German Glioma Network. Complementary therapy use in patients with glioma: an observational study. Neurology. 2010;75(24):2229–35. doi:10.1212/WNL.0b013e31820202c6. PubMed PMID: 21172846.

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Authors and Affiliations

  1. Department of Neurological Surgery, University Hospitals-Cleveland Medical Center and Case Western Reserve University School of Medicine, 11100 Euclid Avenue, HAN 524, Cleveland, OH, 44106, USA

    James Wright & Andrew Edward Sloan

  2. Department of Pathology, University Hospitals-Cleveland Medical Center and Case Western Reserve University School of Medicine, 11100 Euclid Avenue, HAN 524, Cleveland, OH, 44106, USA

    Andrew Edward Sloan

  3. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, HAN 524, Cleveland, OH, 44106, USA

    Andrew Edward Sloan

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  1. James Wright
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Correspondence to Andrew Edward Sloan .

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Editors and Affiliations

  1. Department of Neurosurgery, Montpellier University Medical Center, INSERM U1051, Institute for Neurosciences of Montpellier, Montpellier, France

    Hugues Duffau

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Wright, J., Sloan, A.E. (2017). Emerging Therapies for Diffuse Low Grade Glioma. In: Duffau, H. (eds) Diffuse Low-Grade Gliomas in Adults. Springer, Cham. https://doi.org/10.1007/978-3-319-55466-2_29

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  • DOI: https://doi.org/10.1007/978-3-319-55466-2_29

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