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Radiation Oncology for Pediatric CNS Tumors pp 89–104Cite as

Chemotherapeutic Strategies in Brain Tumors

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Abstract

Brain tumors are the commonest solid tumor in children and chemotherapy remains an important treatment as a part of a multidisciplinary approach to treat these malignancies. Over the last two decades, cooperative groups have evaluated clinical trials geared to enhancing therapeutic efficacy and better understanding of the toxicity profile of conventional drugs. Recent molecular characterization of the genomic and epigenomic landscape of these tumors have resulted in an explosion of biological data, providing insights into the signaling pathway and paving the way to target druggable oncogenic drivers. This has ushered in an era of targeted therapy. Even with refinement of these strategies, challenges remain in the inability to comprehensively understand the mechanistic of drug resistance, and suboptimal drug delivery through the blood brain barrier (BBB). The ultimate therapeutic optimism will be achieved, if we are able to combine all these scientific discernments, and be able to depict the most effective chemotherapy and efficient delivery techniques for childhood brain tumors.

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Authors and Affiliations

  1. Department of Pediatrics, Children’s Cancer Hospital, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 87, Houston, TX, 77030, USA

    Soumen Khatua M.D.

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  1. Soumen Khatua M.D.
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Correspondence to Soumen Khatua M.D. .

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  1. Dept. of Radiation Oncology, Mayo Clinic Dept. of Radiation Oncology, Rochester, Minnesota, USA

    Anita Mahajan

  2. MD Anderson Cancer Center, Houston, Texas, USA

    Arnold Paulino

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Khatua, S. (2018). Chemotherapeutic Strategies in Brain Tumors. In: Mahajan, A., Paulino, A. (eds) Radiation Oncology for Pediatric CNS Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-55430-3_5

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