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Second Neoplasms After Successful Treatment for Pediatric Central Nervous System Tumors

  • Mark J. Amsbaugh
  • Shiao Y. WooEmail author
Chapter

Abstract

As survival rates following treatment for pediatric central nervous system tumors continue to improve, it is now clear that survivors of childhood cancer are at risk for a wide range of health, neurocognitive, social, and psychiatric issues. Perhaps the most significant and damaging complication facing survivors of childhood cancers is diagnosis of a second neoplasm. The development of a second neoplasm is a multifactorial process that is influenced by cancer histology, genetics, treatment technique and intensity, and environmental factors. These are a group of histologically diverse cancers that can occur at any location in the body with varied latency times. Many secondary malignant neoplasms have an extremely poor prognosis. While radiotherapy dose and field design been associated with second neoplasm development, new treatment strategies and technologies such as proton therapy have the potential to significantly reduce this devastating complication of treatment. As our ability to understand and quantify the factors that influence risk improve, models accurately predicting individual risk may be incorporated into treatment selection.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyThe University of LouisvilleLouisvilleUSA

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