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Vascular Late Effects of Cranial Radiation

  • Christine Hill-KayserEmail author
  • Louis Constine
Chapter

Abstract

Many pediatric cancer survivors have received cranial radiation as part of multimodality treatment, most commonly those with leukemia and primary tumors of the central nervous system. The effects of radiotherapy on the developing vascular system may be significant, in summary causing the vessels to appear prematurely aged and fragile. As a result of these changes, survivors are at risk for vascular pathologies that include ischemic stroke, vascular malformations such as Moyamoya, aneurysm, and cavernoma, hemorrhage, necrosis, complicated migraines, and other, rarer, syndromes. Certain factors including age, genetic predisposition, and radiation dose and volume may contribute to risk of such pathologies. There is an increasing role for prevention through modifiable risk factors including metabolic factors. Treatment of vascular pathologies arising after radiotherapy remains similar to that recommended for de novo vascular disease.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of Pennsylvania Perelman School of Medicine, The Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of Radiation OncologyUniversity of RochesterRochesterUSA

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