Pituitary Tumors: Pituitary Adenomas and Langerhans Cell Histiocytosis Associated Diabetes Insipidus
Pituitary adenomas are rare in children, with corticotropinomas being the most common pituitary adenoma in pre-pubescent children and prolactinomas being the most common pituitary adenoma in adolescents. In children, the primary management of these tumors is surgical or medical, with radiation reserved for cases of uncontrolled functioning tumors or patients with unresectable residual disease. Diabetes insipidus (DI) is a common manifestation of Langerhans cell histiocytosis (LCH). There is limited data to support early radiation therapy in patients with LCH to the hypothalamic pituitary axis to increase the probability of resolution of DI.
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