Central Nervous System Germinoma

  • Yuta ShibamotoEmail author
  • Shinya Takemoto


Central nervous system (CNS) germinoma, occurring most often in teenagers, is a highly curable tumor. Germinomas have typical clinical and radiological findings; they can have slight elevation of β-human chorionic gonadotropin levels in the serum and/or cerebrospinal fluid and often respond quickly to radiotherapy or chemotherapy. Until recently, radiation therapy has been the standard treatment for CNS germinoma. Germinomas 4 cm or less in diameter can be cured with radiation doses of 40–45 Gy. Regarding the treatment volume, the clinical target volume covering the ventricular system is recommended if no cerebrospinal fluid (CSF) dissemination is present and CSF cytology is negative. Recently, systemic chemotherapy with reduced radiation doses (24–30 Gy) appears to have gained success, but longer follow-up is necessary to draw conclusions regarding the superiority of this treatment over standard-dose radiation therapy. When using a combined approach, whole ventricular irradiation should still be employed.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of RadiologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  2. 2.Department of RadiologyFujieda Heisei Memorial HospitalFujiedaJapan

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