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Oxygen Transport to Tissue XXXIX pp 3–8Cite as

Oxygen Sensing by the Carotid Body: Past and Present

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 977))

Abstract

It is now well established that carotid bodies are sensory organs for monitoring arterial blood oxygen levels and trigger reflexes that are critical for maintaining homeostasis during hypoxemia. This review article provides a brief account of the early studies leading to the discovery of the carotid body as a sensory receptor and addresses current views of O2 sensing mechanism(s) in the carotid body and their physiological importance.

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Acknowledgments

The research in our laboratory is supported by grants from National Institutes of Health, Heart, Lung and Blood Institute PO1-HL-90554 and UH2-HL-123610.

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Authors and Affiliations

  1. Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, 60637, USA

    Nanduri R. Prabhakar & Ying-Jie Peng

Authors
  1. Nanduri R. Prabhakar
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  2. Ying-Jie Peng
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Corresponding author

Correspondence to Nanduri R. Prabhakar .

Editor information

Editors and Affiliations

  1. Department of Radiation and Cellular Oncology, Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, Illinois, USA

    Howard J. Halpern

  2. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Joseph C. LaManna

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Department of Radiation and Cellular Oncology, Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, Illinois, USA

    Boris Epel

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Prabhakar, N.R., Peng, YJ. (2017). Oxygen Sensing by the Carotid Body: Past and Present. In: Halpern, H., LaManna, J., Harrison, D., Epel, B. (eds) Oxygen Transport to Tissue XXXIX. Advances in Experimental Medicine and Biology, vol 977. Springer, Cham. https://doi.org/10.1007/978-3-319-55231-6_1

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