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Multi-scale Biophysical Principles in Clinical Irreversible Electroporation

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Irreversible Electroporation in Clinical Practice

Abstract

Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate—or permeabilize—the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6–13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering and Mechanics, Virginia Tech, 330 Kelly Hall, Blacksburg, VA, USA

    Daniel C. Sweeney & Rafael V. Davalos

  2. Angio Dynamics Inc., Queensbury, NY, USA

    Robert E. Neal II

Authors
  1. Daniel C. Sweeney
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  2. Robert E. Neal II
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  3. Rafael V. Davalos
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Corresponding author

Correspondence to Daniel C. Sweeney .

Editor information

Editors and Affiliations

  1. Department of Radiology and Nuclear Medicine, VU University Amsterdam, Amsterdam, The Netherlands

    Martijn R. Meijerink

  2. Department of Radiology and Nuclear Medicine, VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands

    Hester J. Scheffer

  3. Vascular and Interventional Radiology, Miami University Hospital and Clinics, Miami, Florida, USA

    Govindarajan Narayanan

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Sweeney, D.C., Neal, R.E., Davalos, R.V. (2018). Multi-scale Biophysical Principles in Clinical Irreversible Electroporation. In: Meijerink, M., Scheffer, H., Narayanan, G. (eds) Irreversible Electroporation in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-55113-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-55113-5_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55112-8

  • Online ISBN: 978-3-319-55113-5

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