Skip to main content

18F-FDG PET/CT: Normal Variants, Artefacts, and Pitfalls in Colorectal Cancer

  • Chapter
  • First Online:
PET/CT in Colorectal Cancer

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

Abstract

Colorectal cancer is the third most common cancer worldwide and the second most common cancer in Europe. The role of 18F-FDG (FDG) PET/CT in suspected recurrence, in patients with liver metastases eligible for surgical management, and in treatment response evaluation in colorectal carcinoma is now well established with more data emerging in initial staging of colorectal cancer [1]. FDG PET/CT can influence the management strategies in colorectal patient in up to 30% of the cases [2]. In this context, adequate understanding of the physiological variants, possible artefacts, as well as imaging pitfalls of FDG PET/CT in colorectal carcinoma patients is extremely important.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Laurens ST, Oyen WJ. Impact of fluorodeoxyglucose PET/computed tomography on the management of patients with colorectal cancer. PET Clin. 2015;10(3):345–60.

    Article  PubMed  Google Scholar 

  2. Petersen RK, Hess S, Alavi A, et al. Clinical impact of FDG-PET/CT on colorectal cancer staging and treatment strategy. Am J Nucl Med Mol Imaging. 2014;4(5):471–82.

    PubMed  PubMed Central  Google Scholar 

  3. Kostakoglu L, Hardoff R, Mirtcheva R, Goldsmith SJ. PET—CT fusion imaging in differentiating physiologic from pathologic FDG uptake. Radiographics. 2004;24(5):1411–31.

    Article  PubMed  Google Scholar 

  4. Kostakoglu L, Agress H, Goldsmith SJ. Clinical role of FDG PET in evaluation of cancer patients. Radiographics. 2003;23:315–39.

    Article  PubMed  Google Scholar 

  5. Blake MA, Singh A, Setty BN, et al. Pearls and pitfalls in interpretation of abdominal and pelvic PETCT. Radiographics. 2006;26(5):1335–53.

    Article  PubMed  Google Scholar 

  6. Emmott J, Sanghera B, Chambers J, Wong WL. The effects of Nbutylscopolamine on bowel uptake: an 18FFDG PET study. Nucl Med Commun. 2008;29(1):11–6.

    Article  PubMed  Google Scholar 

  7. Corrigan AJ, Schleyer PJ, Cook GJ. Pitfalls and artifacts in the use of PET/CT in oncology imaging. Semin Nucl Med. 2015;45(6):481–99.

    Article  PubMed  Google Scholar 

  8. Kapoor V, McCook BM, Torok FS. An introduction to PET CT imaging. Radiographics. 2004;24(2):523–43.

    Article  PubMed  Google Scholar 

  9. Sureshbabu W, Mawlawi O. PET/CT imaging artifacts. J Nucl Med Technol. 2005;33(3):156–61. quiz 63–64

    PubMed  Google Scholar 

  10. Mawlawi O, Erasmus JJ, Pan T, et al. Truncation artifact on PET/CT: impact on measurements of activity concentration and assessment of a correction algorithm. AJR Am J Roentgenol. 2006;186(5):1458–67.

    Article  PubMed  Google Scholar 

  11. McDermott S, Skehan SJ. Whole body imaging in the abdominal cancer patient: pitfalls of PET-CT. Abdom Imaging. 2010;35(1):55–69.

    Article  PubMed  Google Scholar 

  12. Donadon M, Bona S, Montorsi M, et al. FDG-PET positive granuloma of the liver mimicking local recurrence after hepatic resection of colorectal liver metastasis. Hepato-Gastroenterology. 2010;57:138–9.

    PubMed  Google Scholar 

  13. Bares R, Klever P, Hauptmann S, et al. F18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer. Radiology. 1994;192(1):79–86.

    Article  CAS  PubMed  Google Scholar 

  14. Friess H, Langhans J, Ebert M, et al. Diagnosis of pancreatic cancer by [18F] fluoro-2-deoxy-d-glucose positron emission tomography. Gut. 1995;36(5):771–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Culverwell AD, Scarsbrook AF, Chowdhury FU. False-positive uptake on 2-[18F]-fluoro-2-deoxy-D-glucose(FDG)positron-emission tomog- raphy/computed tomography(PET/CT) in oncological imaging. Clin Radiol. 2011;66:366–82.

    Article  CAS  PubMed  Google Scholar 

  16. Treglia G, Taralli S, Salsano M, et al. Prevalence and malignancy risk of focal colorectal incidental uptake detected by 18F-FDG-PETorPET/CT: a meta-analysis. Radiol Oncol. 2014;48(2):99–104.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Gontier E, Fourme E, Wartski M, et al. High and typical 18F-FDG bowel uptake in patients treated with metformin. Eur J Nucl Med Mol Imaging. 2008;35:95–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Arun Sasikumar .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Sasikumar, A., Joy, A. (2017). 18F-FDG PET/CT: Normal Variants, Artefacts, and Pitfalls in Colorectal Cancer. In: Du, Y. (eds) PET/CT in Colorectal Cancer. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-54837-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-54837-1_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54836-4

  • Online ISBN: 978-3-319-54837-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics