• Andrew D. Hershey
  • Vincenzo Guidetti
  • Noemi Faedda
Part of the Headache book series (HEAD)


The pathophysiology of migraine is far from resolved. The current theory regards migraine as a complex multifactorial disorder, with both predisposing genetic factors and environmental factors contributing to the attacks [1]. Twin studies have reported that over half of the variation in migraine is attributable to a genetic component, while the remainder is attributable to unshared environmental factors [2–4]. Several studies have identified the role of some genes in the pathophysiology of migraine [5]; however, epigenetic mechanisms may play an important role in the etiology and phenotypic expression of migraine disorders, and these mechanisms may explain how non-genetic factors (such as female hormones, stress, and inflammation) may modulate the severity and frequency of the attacks [1].


Epigenetics Headache Pathophysiology Gene Environment Comorbidity 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Andrew D. Hershey
    • 1
  • Vincenzo Guidetti
    • 2
  • Noemi Faedda
    • 2
  1. 1.Division of Neurology, Cincinnati Children’s Hospital Medical Center and Department of PediatricsCollege of Medicine, University of CincinnatiCincinnatiUSA
  2. 2.Department of Pediatric and Child and Adolescent NeuropsychiatrySapienza University of RomeRomeItaly

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