Abstract
Frequent headache and juvenile fibromyalgia (JFM) are common conditions observed in childhood and adolescents. They can present in isolation or as comorbid conditions. There is no scientific literature investigating this association in adolescents or childhood. There is evidence in adults that headache, particularly migraine, can be a potential risk factor for developing fibromyalgia (FMS) and that migraine can be also a comorbid and perpetuating factor of FMS. Comorbidity between these two conditions can lead to increased levels of sensitization of the central nervous system and limit therapeutic approaches. Additionally, the presence of comorbid FMS and migraine is associated with worse clinical presentation and higher psychological disturbances. Early identification of risk factors for development of this comorbid association seems to be a challenge for pediatric clinicians.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311:1547–55.
Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013;17:356.
Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheum. 2008;58:26–35.
English B. Neural and psychosocial mechanisms of pain sensitivity in fibromyalgia. Pain Manag Nurs. 2014;15:530–8.
Cagnie B, Coppieter I, Denecker S, Six J, Danneels L, Meeus M. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin Arthritis Rheum. 2014;44:68–75.
de Tommaso M, Nolano M, Iannone F, et al. Update on laser-evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features. J Neurol. 2014;261:461–72.
Üçeyler N, Zeller D, Kahn AK, et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136:1857–67.
Buskila D. Pediatric fibromyalgia. Rheum Dis Clin N Am. 2009;35:253–61.
Galanopoulos N, Kampakis G, Ladopoulou K. [Fibromyalgia and chronic fatigue syndrome in children and adolescents]. Psychiatriki. 2007;18:156–67.
Lynch-Jordan AM, Sil S, Bromberg M, Ting TV, Kashikar-Zuck S. Cross-sectional study of young adults diagnosed with juvenile fibromyalgia: social support and its impact on functioning and mood. J Adolesc Health. 2015;57:482–7.
Yunus MB, Masi AT. Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis Rheum. 1985;28:138–45.
Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160–70.
Kashikar-Zuck S, Cunningham N, Sil S, et al. Long-term outcomes of adolescents with juvenile-onset fibromyalgia in early adulthood. Pediatrics. 2014;133:e592–600.
Zernikow B, Gerhold K, Bürk G, et al. [Definition, diagnosis and therapy of chronic widespread pain and so-called fibromyalgia syndrome in children and adolescents. Systematic literature review and guideline]. Schmerz. 2012;26:318–30.
Otu-Nyarko CG, Gedalia A, Karpinski AC, Kolomensky A, Hyman PE. Disability in children and adolescents with irritable bowel syndrome and/or fibromyalgia. J Pediatr Gastroenterol Nutr. 2015;61:558–60.
Gedalia A, García CO, Molina J, Bradford NJ, Espinoza LR. Fibromyalgia syndrome: experience in a pediatric rheumatology clinic. Clin Exp Rheumatol. 2000;18:415–9.
Kashikar-Zuck S, Ting TV. Juvenile fibromyalgia: current status of research and future developments. Nat Rev Rheumatol. 2014;10:89–96.
Ablin JN, Buskila D. Predicting fibromyalgia, a narrative review: are we better than fools and children? Eur J Pain. 2014;18:1060–6.
Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z. Hypermobility in women with fibromyalgia syndrome. Clin Rheumatol. 2006;25:291–3.
McCluskey G, O’Kane E, Hann D, Weekes J, Rooney M. Hypermobility and musculoskeletal pain in children: a systematic review. Scand J Rheumatol. 2012;41:329–38.
Kashikar-Zuck S, King C, Ting TV, Arnold LM. Juvenile fibromyalgia: different from the adult chronic pain syndrome? Curr Rheumatol Rep. 2016;18:19.
Eccleston C, Palermo TM, Williams AC, et al. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2014;(5):CD003968.
Sherry DD, Brake L, Tress JL, Sherker J, Fash K, Ferry K, Weiss PF. The treatment of juvenile fibromyalgia with an intensive physical and psychosocial program. J Pediatr. 2015;167:731–7.
Sil S, Arnold LM, Lynch-Jordan A, et al. Identifying treatment responders and predictors of improvement after cognitive-behavioral therapy for juvenile fibromyalgia. Pain. 2014;155:1206–12.
Hershey AD. Genetics of headache in children: where are we headed? Curr Pain Headache Rep. 2008;12:367–72.
Wöber-Bingöl C. Epidemiology of migraine and headache in children and adolescents. Curr Pain Headache Rep. 2013;17:341.
Li H, Tfelt-Hansen P, Russell MB, Skythe A, Kyvik KO, Olesen J. Co-morbidity of migraine with somatic disease in a large population-based study. Cephalalgia. 2011;31:43–64.
El-Metwally A, Salminen JJ, Auvinen A, Macfarlane G, Mikkelsson M. Risk factors for development of non-specific musculoskeletal pain in preteens and early adolescents: a prospective 1-year follow-up study. BMC Musculoskelet Disord. 2007;8:46.
Markkula RA, Kalso EA, Kaprio JA. Predictors of fibromyalgia: a population-based twin cohort study. BMC Musculoskelet Disord. 2016;17:29.
Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A. Frequency of migraine headaches in patients with fibromyalgia. Headache. 2015;55:860–5.
Tietjen G, Herial N, Hardgrove J, Ultely C, White L. Migraine comorbidity constellations. Headache. 2007;47:857–65.
de Tommaso M, Federici A, Serpino C, Vecchio E, Franco G, Sardaro M, et al. Clinical features of headache patients with fibromyalgia comorbidity. J Headache Pain. 2011;12:629–38.
de Tommaso M, Sardaro M, Serpino C, Costantini F, Vecchio E, Prudenzano MP, Lamberti P, Livrea P. Fibromyalgia comorbidity in primary headaches. Cephalalgia. 2009;29:453–64.
Tietjen GE, Brandes JL, Peterlin BL, et al. Childhood maltreatment and migraine (part III). Association with comorbid pain conditions. Headache. 2010;50:42–51.
Tietjen GE, Brandes JL, Peterlin B, et al. Allodynia in migraine: association with comorbid pain conditions. Headache. 2009;49:1333–44.
Giamberardino MA, Affaitati G, Martelletti P, et al. Impact of migraine on fibromyalgia symptoms. J Headache Pain. 2015;17:28.
de Tommaso M, Ambrosini A, Brighina F, et al. Altered processing of sensory stimuli in patients with migraine. Nat Rev Neurol. 2014;10:144–55.
de Tommaso M, Federici A, Santostasi R, Calabrese R, Vecchio E, Lapadula G, Iannone F, Lamberti P, Livrea P. Laser-evoked potentials habituation in fibromyalgia. J Pain. 2011;12:116–24.
Kashikar-Zuck S, Zafar M, Barnett K, et al. Quality of life and emotional functioning in youth with chronic migraine and juvenile fibromyalgia. Clin J Pain. 2013;29:1066–72.
Pinquart M, Shen Y. Depressive symptoms in children and adolescents with chronic physical illness: an updated meta-analysis. J Pediatr Psychol. 2011;36:375–84.
de Tommaso M, Federici A, Loiacono A, Delussi M, Todarello O. Personality profiles and coping styles in migraine patients with fibromyalgia comorbidity. Compr Psychiatry. 2014;55:80–6.
Liu HY, Fuh JL, Lin YY, Chen WT, Wang SJ. Suicide risk in patients with migraine and comorbid fibromyalgia. Neurology. 2015;85:1017–23.
Kashikar-Zuck S, Lynch AM, Slater S, Graham TB, Swain NF, Noll RB. Family factors, emotional functioning, and functional impairment in juvenile fibromyalgia syndrome. Arthritis Rheum. 2008;59:1392–8.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Fernández-de-las-Peñas, C., Valeriani, M. (2017). Comorbidity with Fibromyalgia. In: Guidetti, V., Arruda, M., Ozge, A. (eds) Headache and Comorbidities in Childhood and Adolescence. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-54726-8_18
Download citation
DOI: https://doi.org/10.1007/978-3-319-54726-8_18
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-54725-1
Online ISBN: 978-3-319-54726-8
eBook Packages: MedicineMedicine (R0)