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Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy

Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.,volume 3)

Abstract

Natriuretic peptides have received considerable attention in the recent years both as biomarkers for heart failure and as treatment for the disease. Atrial (ANP) and B-type natriuretic peptide (BNP) stimulate the natriuretic peptide receptor (NPR)-A, whereas C-type natriuretic peptide (CNP) stimulates the NPR-B. Both NPR-A and NPR-B are guanylyl cyclases which generate cGMP when stimulated. All three peptides bind the NPR-C which does not possess guanylyl cyclase (GC) activity. Evidence is accumulating that natriuretic peptides are involved in regulating contractility and hypertrophic responses through a complex system of signalling pathways, both cGMP dependent and independent, in different compartments in cardiomyocytes. This review discusses compartmentalisation of natriuretic peptide signalling in cardiomyocytes, with focus on contractile and antihypertrophic effects in healthy and diseased hearts.

Keywords

  • Natriuretic peptides
  • Compartmentation
  • cGMP
  • Hypertrophy
  • Contractility
  • Cardiomyocytes
  • GC-A
  • GC-B

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Fig. 12.1
Fig. 12.2

Notes

  1. 1.

    https://clinicaltrials.gov/ct2/show/NCT00839007, https://clinicaltrials.gov/ct2/show/NCT00620308, https://clinicaltrials.gov/ct2/show/NCT02071602, https://clinicaltrials.gov/ct2/show/NCT01750905, https://clinicaltrials.gov/ct2/show/nct02359227

  2. 2.

    https://clinicaltrials.gov/ct2/show/NCT01920711

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Moltzau, L.R., Meier, S., Andressen, K.W., Levy, F.O. (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy. In: Nikolaev, V., Zaccolo, M. (eds) Microdomains in the Cardiovascular System. Cardiac and Vascular Biology, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-319-54579-0_12

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