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The Pharmacology and Therapeutic Potential of Plant Cannabinoids

  • Maria Grazia CascioEmail author
  • Roger G. Pertwee
  • Pietro Marini
Chapter

Abstract

The plant Cannabis sativa has been widely used by humans over many centuries as a source of fibre, for medicinal purposes, for religious ceremonies and as a recreational drug. Since the discovery of its main psychoactive ingredient, Δ9-tetrahydrocannabinol (THC), significant progress has been made towards the understanding (1) of the in vitro and in vivo pharmacology both of THC and of certain other cannabis-derived compounds, and (2) of the potential and actual uses of these “phytocannabinoids” as medicines. There is now extensive evidence that the pharmacological effects of some widely-studied phytocannabinoids, are due to their ability to interact with cannabinoid receptors and/or with other kinds of pharmacological targets, including non-cannabinoid receptors, and this makes the pharmacology of the phytocannabinoids rather complex and interesting. In this chapter, we provide an overview of the in vitro pharmacology of five selected phytocannabinoids and report findings that have identified potential new therapeutic uses for these compounds.

Keywords

Mouse Brain Membrane House Musk Shrew TRPM8 Cation Channel Cannabidiolic Acid TRPV3 Cation Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

THC

Tetrahydrocannabinol

CBD

Cannabidiol

CBG

Cannabigerol

THCV

Tetrahydrocannabivarin

CBC

Cannabichromene

CBDV

Cannabidivarin

CBDA

Cannabidiolic acid

CBGV

Cannabigerovarin

CBGA

Cannabigerolic acid

THCA

Tetrahydrocannabinolic acid

THCVA

Tetrahydrocannabivarinic acid

TRP

Transient receptor potential

PPAR

Peroxisome-proliferator activated receptor

GPCR

G-protein coupled receptor

CB

Cannabinoid

HT

Hydroxytryptamine

8-OH-DPAT

8-hydroxy-2-(di-n-propylamino)-tetralin

HU-201

6aR,10aR)- 9-(Hydroxymethyl)- 6,6-dimethyl- 3-(2-methyloctan-2-yl)- 6a,7,10,10a-tetrahydrobenzo [c]chromen- 1-ol

WIN55212

[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate

CP55940

(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol

GTPγS

Guanosine 5′-O-[gamma-thio]triphosphate)

AMP

Adenosine monophosphate

ERK

Extracellular signal-regulated kinases

CHO

Chinese hamster ovary

NAM

Negative allosteric modulator

SR141716A

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

WAY100135

(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride

WAY100635

N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate

AM251

N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Maria Grazia Cascio
    • 1
    Email author
  • Roger G. Pertwee
    • 1
  • Pietro Marini
    • 1
  1. 1.School of Medicine, Medical Sciences and NutritionInstitute of Medical Sciences, University of AberdeenForesterhill, AberdeenUK

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