Abstract
Amygdala plays an important role in fear and emotional learning, which are critical for human survival. Despite the functional relevance and unique circuitry of each human amygdaloid subnuclei, there has yet to be an efficient imaging method for identifying these regions in vivo. A data-driven approach without prior knowledge provides advantages of efficient and objective assessments. The present study uses high angular and high spatial resolution diffusion magnetic resonance imaging to generate orientation distribution function, which bears distinctive microstructural features. The features were extracted using spherical harmonic decomposition to assess microstructural similarity within amygdala subfields that are identified via similarity matrices using spectral k-mean clustering. The approach was tested on 32 healthy volunteers and three distinct amygdala subfields were identified including medial, posterior-superior lateral, and anterior-inferior lateral.
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Acknowledgements
Supported in part by Dartmouth Synergy, Indiana Alzheimer Disease Center pilot grant, NIH R01 MH080716, R01 EB022574, R01 LM011360, R01 AG19771 and P30 AG10133.
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Wen, Q., Stirling, B.D., Sha, L., Shen, L., Whalen, P.J., Wu, YC. (2017). Parcellation of Human Amygdala Subfields Using Orientation Distribution Function and Spectral K-means Clustering. In: Fuster, A., Ghosh, A., Kaden, E., Rathi, Y., Reisert, M. (eds) Computational Diffusion MRI. MICCAI 2016. Mathematics and Visualization. Springer, Cham. https://doi.org/10.1007/978-3-319-54130-3_10
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DOI: https://doi.org/10.1007/978-3-319-54130-3_10
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