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Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology

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Macrophages

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 62))

Abstract

Tissue homeostasis is not only controlled by biochemical signals but also through mechanical forces that act on cells. Yet, while it has long been known that biochemical signals have profound effects on cell biology, the importance of mechanical forces has only been recognized much more recently. The types of mechanical stress that cells experience include stretch, compression, and shear stress, which are mainly induced by the extracellular matrix, cell–cell contacts, and fluid flow. Importantly, macroscale tissue deformation through stretch or compression also affects cellular function.

Immune cells such as macrophages and dendritic cells are present in almost all peripheral tissues, and monocytes populate the vasculature throughout the body. These cells are unique in the sense that they are subject to a large variety of different mechanical environments, and it is therefore not surprising that key immune effector functions are altered by mechanical stimuli. In this chapter, we describe the different types of mechanical signals that cells encounter within the body and review the current knowledge on the role of mechanical signals in regulating macrophage, monocyte, and dendritic cell function.

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Authors and Affiliations

  1. Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands

    Svenja F. B. Mennens, Koen van den Dries & Alessandra Cambi

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  1. Svenja F. B. Mennens
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  2. Koen van den Dries
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  3. Alessandra Cambi
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Correspondence to Alessandra Cambi .

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  1. Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA

    Malgorzata Kloc

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Mennens, S.F.B., van den Dries, K., Cambi, A. (2017). Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology. In: Kloc, M. (eds) Macrophages. Results and Problems in Cell Differentiation, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-319-54090-0_9

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