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Macrophages pp 61–72Cite as

Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 62))

Abstract

Mesenchymal stem cells (MSC) are multipotent stem cells with a broad well-described immunosuppressive potential. They are able to modulate both the innate and the adaptive immune response. Particularly, MSC are able to regulate the phenotype and function of macrophages that are critical for different biological processes including wound healing, inflammation, pathogenesis of several autoimmune diseases, and tumor growth. These multifunctional roles of macrophages are due to their high plasticity, which enable them to adopt different phenotypes such as a pro-inflammatory M1 and anti-inflammatory M2 phenotype. MSC promote macrophage differentiation toward an M2-like phenotype with a high tissue remodeling potential and anti-inflammatory activity but also a pro-tumorigenic function. MSC regulatory effect on macrophages is mediated through the secretion of different immunomodulatory molecules such as PGE2, IL1RA, and IL-6. Moreover, the presence of macrophages in damaged tissue and inflammation is essential for MSC to exert their therapeutic function. In this chapter, we discuss how the interplay between macrophages and MSC mutually modulates their phenotypes and functions, orchestrates tissue repair, and controls inflammation during autoimmunity and tumor growth.

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Authors and Affiliations

  1. Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile

    Patricia Luz-Crawford

  2. Inserm U1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France

    Christian Jorgensen & Farida Djouad

  3. Université de Montpellier, Montpellier, 34000, France

    Christian Jorgensen & Farida Djouad

  4. Service d’Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, 34295, France

    Christian Jorgensen

Authors
  1. Patricia Luz-Crawford
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  2. Christian Jorgensen
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  3. Farida Djouad
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Corresponding authors

Correspondence to Patricia Luz-Crawford or Farida Djouad .

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Editors and Affiliations

  1. Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA

    Malgorzata Kloc

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Luz-Crawford, P., Jorgensen, C., Djouad, F. (2017). Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages. In: Kloc, M. (eds) Macrophages. Results and Problems in Cell Differentiation, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-319-54090-0_4

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