Terahertz Spectroscopy Applications in Medicament Analysis

Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 428)


Terahertz spectroscopy came to the attention of the broader scientific community in the 90s of the 20th century with the development of science and technology in particular, enabling to work in terahertz spectral region. Terahertz spectroscopy has a wide possibilities of applications beginning in classical spectroscopy of gun powders, plastics, explosives, liquids, through terahertz imaging of medicaments, tissues, materials or layers, to remote observation/identification of hidden objects mainly for security purposes. The aim of this paper is to introduce possible applications in analysis of pharmaceuticals with different amount of active ingredient content. According to the results, the classical terahertz spectroscopy is not as suitable as other spectroscopic methods targeted on analyzing content of pharmaceuticals showing persistent inconveniences of this spectroscopy. All measurements were done using the TPS Spectra 3000 instrument.


Attenuated total reflection (ATR) terahertz time-domain spectroscopy Terahertz imaging Transmittance Absorbance Pharmaceutical analysis Euthyrox 



This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme project No. LO1303 (MSMT-7778/2014) and the European Regional Development Fund under the project CEBIA-Tech (CZ.1.05/2.1.00/03.0089). The authors declare no competing financial interests.


  1. 1.
    Shen, Y.C., Taday, P.F., Newnham, D.A., Pepper, M.: Chemical mapping using reflection terahertz pulsed imaging. Semicond. Sci. Technol. 20, S254–S257 (2005)CrossRefGoogle Scholar
  2. 2.
    Soltani, A., Jahn, D., Duschek, L., Castro-Camus, E., Koch, M., Withayachumnankul, W.: Attenuated total reflection terahertz time-domain spectroscopy: uncertainty analysis and reduction scheme. IEEE Trans. Terahertz Sci. Technol. 6, 1–8 (2015)Google Scholar
  3. 3.
    Banerjee, D., von Spiegel, W., Thomson, M.D., Schabel, S., Roskos, H.G.: Diagnosing water content in paper by terahertz radiation. Opt. Express 16, 9060–9066 (2008)CrossRefGoogle Scholar
  4. 4.
    Watanabe, Y., Kawase, K., Ikari, T., Ito, H., Ishikawa, Y., Minamide, H.: Component spatial pattern analysis of chemicals using terahertz spectroscopic imaging. Appl. Phys. Lett. 83, 800–802 (2003)CrossRefGoogle Scholar
  5. 5.
    Ajito, K., Ueno, Y., Song, H.-J.: Visualization of pharmaceutical drug molecules by Terahertz chemical imaging. NTT Tech. Rev. 10 (2012)Google Scholar
  6. 6.
    Giles, J.P., Raitt, B.J., Joseph, C.S., Hines, M.E., Giles, R.H.: Investigating the effects of terahertz radiation on Bacillus subtilis. In: Tuchin V.V., Duncan D.D., Larin K.V., Leahy M.J., Wang R.K. (eds.) Proceedings SPIE 8222; Dynamics and Fluctuations in Biomedical Photonics IX. p. 9. SPIE (2012)Google Scholar
  7. 7.
    Sun, Y., Fischer, M.B., MacPherson, E.P.: Effects of formaling fixing on the THz properties of biological tissues. J. Biol. Opt. 14(6), 6401–6417 (2009)Google Scholar
  8. 8.
    Globus, T., Bykhovskaia, M., Woolard, D., Gelmont, B.: Sub-millimetre wave absorption spectra of artificial RNA molecules. J. Phys. D Appl. Phys. 36, 1314–1322 (2003)CrossRefGoogle Scholar
  9. 9.
    Jin, Y., Kim, G., Jeon, S.: Terahertz dielectric properties of polymers. J. Korean Phys. Soc. 49, 513–517 (2006)Google Scholar
  10. 10.
    Suhandy, D., Suzuki, T., Ogawa, Y., Kondo, N., Ishihara, T., Takemoto, Y.: A quantitative study for determination of sugar concentration using attenuated total reflectance terahertz (ATR-THz) spectroscopy. Proceedings SPIE. 8027, 802705–802705-6 (2011)Google Scholar
  11. 11.
    Takebe, G., Kawada, Y., Akiyama, K., Takahashi, H., Takamoto, H., Hiramatsu, M.: Evaluation of drug crystallinity in aqueous suspension using terahertz time-domain attenuated total reflection spectroscopy. J. Pharm. Sci. 102, 4065–4071 (2013)CrossRefGoogle Scholar
  12. 12.
    Liu, G.F., Ma, S.H., Ji, T., Zhao, H.W., Wang, W.F.: Differentiation of illicit drugs with THz time-domain spectroscopy. Nucl. Sci. Tech. 21, 209–213 (2010)Google Scholar
  13. 13.
    Williams, M.R.C., Aschaffenburg, D.J., Ofori-Okai, B.K., Schmuttenmaer, C.A.: Intermolecular vibrations in hydrophobic amino acid crystals: experiments and calculations. J. Phys. Chem. B. 117, 10444–10461 (2013)CrossRefGoogle Scholar
  14. 14.
    Zhang, Q., Gladden, L.F., Avalle, P., Axel Zeitler, J., Mantle, M.D.: Terahertz pulsed imaging and magnetic resonance imaging as tools to probe formulation stability. Pharmaceutics 5, 591–608 (2013)Google Scholar
  15. 15.
    Pharmacopeia, U.S.: Levothyroxine sodium. http://www.pharmacopeia.cn/v29240/usp29nf24s0_m45000.html. Accessed 09 July 2016

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Faculty of Applied Informatics, Department of Electronics and MeasurementTomas Bata University in ZlínZlínCzech Republic

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