Abstract
This chapter deals with a very important topic that needs serious attention from the proponents of Randomized Controlled Trials (RCTs) on invasive and noninvasive surgical procedures. For RCTs, missing data is inevitable irrespective of disease areas and not accounting for missing data mechanisms in the analysis can pose serious concerns about the validity of the trial results. This chapter provides a brief background on missing data which includes common notations, missing data patterns, and missing data mechanisms. The impacts of missing data on the trial findings in absence of a strategy are discussed. Different strategies that can be used during the conduct of the RCT and also during the data analysis are introduced. Variety of analytical methods to deal with missing data with different missing mechanisms are introduced and discussed. The importance of including a sensitivity analysis is also pointed out in this chapter.
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Biswas, K. (2017). Missing Data. In: Itani, K., Reda, D. (eds) Clinical Trials Design in Operative and Non Operative Invasive Procedures. Springer, Cham. https://doi.org/10.1007/978-3-319-53877-8_19
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DOI: https://doi.org/10.1007/978-3-319-53877-8_19
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