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Cell Death and Liver Injuries in Hepatitis C Virus Infection

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Cellular Injury in Liver Diseases

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Hepatitis C virus (HCV) causes chronic infection in most of the patients that it infects, and this chronic infection can lead to severe liver diseases including fatty liver, cirrhosis, and hepatocellular carcinoma. HCV infection of hepatocytes can suppress the host innate immune response, and this suppression plays an important role in the establishment of chronic HCV infection. HCV can also induce the expression of pro-inflammatory cytokines to cause chronic liver inflammation and cell death. It can also induce endoplasmic reticulum stress, oxidative stress, apoptosis, and hepatocellular proliferation and alter hepatic lipid metabolism. These combined effects of HCV can lead to chronic liver injury and hepatocellular carcinogenesis. In this chapter, we will review the interactions between HCV and its host cells.

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  1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Jiyoung Lee & Jing-hsiung James Ou

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Correspondence to Jing-hsiung James Ou .

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  1. Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA

    Wen-Xing Ding

  2. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

    Xiao-Ming Yin

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Lee, J., Ou, Jh.J. (2017). Cell Death and Liver Injuries in Hepatitis C Virus Infection. In: Ding, WX., Yin, XM. (eds) Cellular Injury in Liver Diseases. Cell Death in Biology and Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-53774-0_4

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