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Mechanisms of Molecular Carcinogenesis – Volume 1 pp 87–114Cite as

NF-κB and Its Implication in Liver Health and Cancer Development

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Abstract

Nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) belongs to one of the best described and most intensively studied transcription factors in biochemistry in the last 30 years. The NF-κB signaling cascade exists in two variants, the canonical and noncanonical pathway, and its transcription factors are key regulators of several biochemical processes like immune responses, inflammation, survival, and cellular development and growth.

Examination of various transgenic mouse models targeting NF-κB itself or signaling members discovered the implication of NF-κB in chronic inflammatory diseases and cancer development in different organs as in the skin, intestine, and liver.

In this review the focus lies on the central organ of metabolic and inflammatory processes: the liver. It seems that NF-κB is pivotal for the homeostasis in the different hepatic cell types concerning hepatic failure, fibrosis, and HCC progression. NF-κB has the ability to be a potential target in the attempt to circumvent or medicate liver fibrosis and HCC.

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Authors and Affiliations

  1. Department of Translational Inflammation Research, Medical Faculty, Otto-von-Guericke University, Pfälzer Platz, Building 28, 39106, Magdeburg, Germany

    Kira Bettermann

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  1. Kira Bettermann
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Correspondence to Kira Bettermann .

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  1. Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

    Johannes Haybaeck

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Bettermann, K. (2017). NF-κB and Its Implication in Liver Health and Cancer Development. In: Haybaeck, J. (eds) Mechanisms of Molecular Carcinogenesis – Volume 1. Springer, Cham. https://doi.org/10.1007/978-3-319-53659-0_6

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