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Cord Blood Transplants for Lymphoid Malignancies in Adults

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Cord Blood Transplantations

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Abstract

Umbilical cord blood transplantation (UCBT) has emerged as a viable treatment strategy for patients with high-risk lymphoid malignancies such as acute lymphoblastic leukemia and advanced mature lymphoproliferative disorders. Donor-derived, immune-mediated graft-versus-tumor responses may result in long-term disease control and potential cure. Because of the proliferative potential of UCB hematopoietic cells, the UCB cell dose can be nearly ten times lower than the dose used for peripheral blood transplants; however, the number of cells obtained with a single UCB unit is limited, and double UCB unit transplants are often required for adults. We review the data on the use of UCBT in acute lymphoblastic leukemia in adults and the extended use of reduced intensity conditioning UCBT for non-Hodgkin lymphoma, Hodgkin lymphoma, and chronic lymphocytic leukemia.

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Authors and Affiliations

  1. University of Minnesota, 420 Delaware Street, Minneapolis, MN, 55455, USA

    Veronika Bachanova MD, PhD

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  1. Veronika Bachanova MD, PhD
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Correspondence to Veronika Bachanova MD, PhD .

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Editors and Affiliations

  1. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Mitchell Horwitz

  2. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Nelson Chao

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Bachanova, V. (2017). Cord Blood Transplants for Lymphoid Malignancies in Adults. In: Horwitz, M., Chao, N. (eds) Cord Blood Transplantations. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-53628-6_11

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  • DOI: https://doi.org/10.1007/978-3-319-53628-6_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53627-9

  • Online ISBN: 978-3-319-53628-6

  • eBook Packages: MedicineMedicine (R0)

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