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Historical Perspective and Current Trends of Umbilical Cord Blood Transplantation

  • Eliane GluckmanEmail author
  • Annalisa Ruggeri
Chapter
Part of the Advances and Controversies in Hematopoietic Transplantation and Cell Therapy book series (ACHTCT)

Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment for patients with hematological diseases. HLA-matched donors could be either siblings or unrelated donors found in international registries for unrelated donors. Patients in need of allo-HCT may also benefit of a HLA-mismatched allo-HCT either from a haploidentical donor or from umbilical cord blood (UCB). Much has been learned about UCBT since the first human cord blood transplant (UCBT) was performed back in 1988. Cord blood banks have been established worldwide for the collection, cryopreservation, and distribution of UCB for allo-HCT. Today, a global network of cord blood banks and transplant centers has been established with a large common inventory of more than 650,000 UCB units available, allowing for more than 40,000 UCBT worldwide in children and adults with severe hematological diseases. Several studies have been published on UCBT, assessing risk factors such as cell dose and HLA mismatch. Outcomes of several retrospective comparative studies showed similar results using other graft sources both in pediatric and adult settings. New strategies are ongoing to facilitate engraftment and reduce transplant-related mortality.

Keywords

Cord blood banking Cord blood transplantation Malignant and nonmalignant hematological diseases 

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Eurocord, Hopital Saint LouisParis Cedex 10France
  2. 2.Monacord, Centre scientifique de MonacoMonacoFrance
  3. 3.Service d’Hématologie et Thérapie CellulaireHôpital Saint-AntoineParisFrance

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