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Cartilage pp 189-206 | Cite as

Animal Models in Cartilage Repair

  • Lars Goebel
  • Liang Gao
  • Henning MadryEmail author
Chapter

Abstract

Animal models play an important role to test novel experimental strategies and reconstructive surgical treatments of focal articular cartilage defects. Such animal models need to reflect the different appearances and aetiologies of cartilage defects, e.g. caused by trauma or osteoarthritis. Depth of articular cartilage defects plays an important role. Full-thickness chondral defects do not extend into the subchondral bone, while osteochondral defects penetrate the cement line and extend to the subchondral bone, thereby changing its structural integrity. Mice, rats, rabbits, goat, sheep, minipigs and horses are representing good models, bridging the gap between in vitro studies and clinical experiments in human. Each of them has benefits and limitations. Evaluation of cartilage repair may be performed using a large variety of methods, among which non-destructive evaluations and histological scoring, the latter being considered as the gold standard. As the available reconstructive surgical approaches for articular cartilage repair become increasingly complex, precise animal models to test and to translate new surgical techniques into appropriate clinical treatments are required.

Keywords

Articular Cartilage Subchondral Bone Cartilage Defect Cartilage Repair Cartilage Thickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Center of Experimental OrthopaedicsSaarland University Medical Center and Saarland UniversityHomburgGermany
  2. 2.Cartilage Net of the Greater RegionHomburgGermany
  3. 3.Department of Orthopaedic SurgerySaarland University Medical Center and Saarland UniversityHomburgGermany

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