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Human Spermatogenesis and Its Regulation

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Book cover Male Hypogonadism

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Spermatogenesis in humans is comprised of a series of highly complicated cellular events, necessary to support the production of an upward of 200 million sperm daily from puberty through the entire adulthood of a healthy man. Recent advances in the field using the techniques of cell and molecular biology, genetics, and biochemistry have unraveled many of the mysteries in spermatogenesis. In this Chapter, we highlight some recent advances in the field regarding the biology of human spermatogenesis. We also summarize and discuss recent advances regarding the regulation of spermatogenesis in humans. Due to rapid advances in our understanding of spermatogenesis and the large number of published reports in the literature in the last 2–3 decades, we focus on rapidly developing areas to stimulate the interest of our readers, in particular in areas that offer advances for the treatment of infertility in men.

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Acknowledgements

The authors wish to thank Drs. Stephen Winters and Ilpo Huhtaniemi for their helpful remarks, comments, insightful thoughts, and suggestions during the preparation of this manuscript for this book. Without this valuable help, this Chapter could not have been written.

This work was supported by grants from the National Institutes of Health, R01 HD056034 (to C.Y.C.), U54 HD029990 Project 5 (to C.Y.C.); National Natural Science Foundation of China (NSFC) 31371176 (to X.X.), China Qianjiang Talents Program QJD1502029 (to X.X.) and Zhejiang Province Department of Science Technology Funding 2016F10010 (to X.X.)

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Authors and Affiliations

  1. Center for Biomedical Research, Population Council, 1230 York Ave., New York, NY, 10065, USA

    Haiqi Chen PhD, Dolores Mruk PhD & C. Yan Cheng PhD

  2. Department of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China

    Xiang Xiao PhD

Authors
  1. Haiqi Chen PhD
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  2. Dolores Mruk PhD
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  3. Xiang Xiao PhD
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  4. C. Yan Cheng PhD
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Corresponding author

Correspondence to C. Yan Cheng PhD .

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Editors and Affiliations

  1. Department of Medicine, Endocrinology, D, University of Louisville Health Sciences, Louisville, USA

    Stephen J. Winters

  2. Department of Surgery and Cancer, Imperial College London, London, United Kingdom

    Ilpo T. Huhtaniemi

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Chen, H., Mruk, D., Xiao, X., Cheng, C.Y. (2017). Human Spermatogenesis and Its Regulation. In: Winters, S., Huhtaniemi, I. (eds) Male Hypogonadism. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-53298-1_3

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  • DOI: https://doi.org/10.1007/978-3-319-53298-1_3

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