We have seen that health and development have multiple definitions and there are multiple approaches to obtaining them. No single perspective or approach is correct or can address every desirable aspect of the development enterprise. While in the past, health took a secondary position to economic development, that changed in the 21st century. We now see that sustainable development entails economic, social and environmental sectors and the concept of human development stresses the importance of human health and education as a constituent of economic growth. The Millennium Development Goals and Sustainable Development Goals approach health as being critical to the development process. Global collaborations now focus on development as a holistic process that entails economic and social aspects, with more resources are directed specifically towards health. The promise of the 21st century is to see new directions and new developments in the global endeavor of development. The challenge is to sustain these efforts.