Eye Movement Behavior Analyses for Studying Cognitive Performance and Conversion to Pathologies
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The interest of linking eye movement and reading has shown an exponential growth in the last decades. Additionally, the technology for tracking gaze position has advanced considerably and has become widely available for its use. Reading is a feedback process that requires the integration of different cognitive systems, and is an ideal field for exploring the relationships between eye movements and top-down processes. Several of the associated cognitive processes such as working memory and semantic memory are known to be relevant when reading sentences. For example, during reading high-predictable sentences the upcoming word predictability facilitates word processing in healthy readers. In the present chapter, we show the effect of contextual word predictability on the eye-movement behavior in patients with mild cognitive impairment due to dementia and to neuropsychiatric pathologies (i.e., Alzheimer’s disease and schizophrenia respectively) in comparison with control groups of similar ages and education. The differences in the pattern are clearly presented. Our results show that it is possible to develop a new, objective, noninvasive, and economical technique to evaluate mild cognitive impairments that could help in the early and proper diagnosis of such pathologies.
KeywordsCognition Eye movements; Alzheimer: schizophrenia Early diagnosis
This work was supported by the Agencia Nacional de Promoción Científica y Tecnológica from Argentina under grant PICT 2013 0403, the Universidad Nacional del Sur under grant PGI 24/K048, and CIC.
- 1.Buswell GT. The psychology of seeing. New York: Philosophical Library; 1935.Google Scholar
- 9.Taylor W. Cloze procedure: a new tool for measuring readability. Journalism Q. 1953;30:415–33.Google Scholar
- 11.Sebastián-Gallés N, Martí M, Cuetos F, Carreiras M. LEXESP: Léxico informatizado del español. Barcelona: Ediciones de la Universidad de Barcelona; 1998.Google Scholar
- 12.Bates D, Maechler M. lme4: linear mixed-effect models using S4 classes R package version 0.995–2. Vienna: R Foundation for Statistical Computing; 2013.Google Scholar
- 15.Frank RA, Galasko D, Hampel H, Hardy J, de Leon MJ, Mehta PD, Rogers J, Siemers E, Trojanowski JQ, National Institute on Aging Biological Markers Working Group. Biological markers for therapeutic trials in Alzheimer’s disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease. Neurobiol Aging. 2003;24(4):521–36.CrossRefPubMedGoogle Scholar
- 17.McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS–ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology. 1984;34(7):939–44.CrossRefPubMedGoogle Scholar
- 18.American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. Washington, DC: American PsychiatricAssociation; 1994.Google Scholar
- 21.Hayes RL, O’Grady BM. Do people with schizophrenia comprehend what they read? Schizophr Bull. 2003;29:499–507. http://dx.doi.org/10.1093/oxfordjournals.schbul.a007022 CrossRefPubMedGoogle Scholar
- 22.Revheim N, et al. Reading impairment and visual processing deficits in schizophrenia. Schizophr Res. 2006;87:238–45. http://dx.doi.org/10.1016/j.schres.2006.06.022
- 23.Arnott W, Sali L, Copland D. Impaired reading comprehension in schizophrenia: evidence for underlying phonological processing deficits. Psychiatry Res. 2011;187:6–10. http://dx.doi.org/10.1016/j.psychres.2010.11.025.
- 26.Kuperberg GR. Language in schizophrenia (part2): what can psycho-linguistics bring to the study of schizophrenia and viceversa? Lang. Linguist.Compass. 2010;4:590–604. http://dx.doi.org/10.1111/j.1749-818X.2010.00217.x.
- 27.Levy DL, et al. The genetic basis of thought disorder and language and communication disturbances in schizophrenia. J Neurolinguistics. 2010;23:176–92. http://dx.doi.org/10.1016/j.jneuroling.2009.08.003.CrossRefPubMedPubMedCentralGoogle Scholar
- 30.First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM–IV axis I disorders. NewYork: NewYork State Psychiatric Institute; 1996.Google Scholar
- 32.Wechsler D. Manual for the Wechsler adult intelligence scale—revised. New York: Psychological Corporation; 1981.Google Scholar
- 33.Hollingshead AB. Four-factor index of social status. Unpublished manuscript: Yale University; 1975.Google Scholar
- 34.Alberta MS, DeKosky ST, Dickson D, Duboise B, Feldman H, Fox N, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9. doi: 10.1016/j.jalz.2011.03.008.CrossRefGoogle Scholar