Left Atrial Appendage Segmentation Based on Ranking 2-D Segmentation Proposals
The left atrial appendage (LAA) is the main source of thrombus in patients with atrial fibrillation (AF). Automated segmentation of the LAA can greatly help doctors diagnose thrombosis and plan LAA closure surgery. Considering large anatomical variations of the LAA, we present a non-model based semi-automated approach for LAA segmentation on CTA data. The method requires only manual selection of four fiducial points to obtain the bounding box for the LAA. Subsequently we generate a pool of segmentation proposals using parametric max-flow for each 2-D slice. Then a random forest regressor is trained to pick out the best 2-D proposal for each slice. Finally all selected 2-D proposals are merged into a 3-D model using spatial continuity. Experimental results on 60 CTA data showed that our approach was robust when dealing with large anatomical variations. Compared to manual annotation, we obtained an average dice overlap of 95.12%.
KeywordsLeft atrial appendage LAA closure surgery Non-model based segmentation Ranking
This work is supported by the National Natural Science Foundation of China under Grants 61225008, 61373074, 61572271, 61527808 and 61373090, the National Basic Research Program of China under Grant 2014CB349304, the Ministry of Education of China under Grant 20120002110033, and the Tsinghua University Initiative Scientific Research Program.
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