Abstract
This middle-aged woman presented with 6 months of vague upper abdominal pain and unintentional weight loss.
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References
Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, Tang D, et al. Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol. 1998;152(6):1501–7.
Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, Sohn TA, et al. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol. 2000;156(5):1641–51. doi:10.1016/S0002-9440(10)65035-3.
Hruban RH, Pittman MB, Klimstra DS. Tumors of the pancreas, 4th series. Washington, DC: ARP Press; 2007.
Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009;133(3):365–74. doi:10.1043/1543-2165-133.3.365.
Nakata B, Wang YQ, Yashiro M, Nishioka N, Tanaka H, Ohira M, et al. Prognostic value of microsatellite instability in resectable pancreatic cancer. Clin Cancer Res. 2002;8(8):2536–40.
Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, Raymond VM, et al. Risk of pancreatic cancer in families with Lynch syndrome. JAMA. 2009;302(16):1790–5. doi:10.1001/jama.2009.1529.
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372(26):2509–20. doi:10.1056/NEJMoa1500596.
Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349(3):247–57. doi:10.1056/NEJMoa022289.
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Laxton, W. (2017). Case 72: Pancreatic Ductal Adenocarcinoma with Medullary Features. In: Zaheer, A., Fishman, E., Pittman, M., Hruban, R. (eds) Pancreatic Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-52680-5_72
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DOI: https://doi.org/10.1007/978-3-319-52680-5_72
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