Skip to main content

Case 72: Pancreatic Ductal Adenocarcinoma with Medullary Features

  • Chapter
  • First Online:
Pancreatic Imaging

Abstract

This middle-aged woman presented with 6 months of vague upper abdominal pain and unintentional weight loss.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, Tang D, et al. Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol. 1998;152(6):1501–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, Sohn TA, et al. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol. 2000;156(5):1641–51. doi:10.1016/S0002-9440(10)65035-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hruban RH, Pittman MB, Klimstra DS. Tumors of the pancreas, 4th series. Washington, DC: ARP Press; 2007.

    Google Scholar 

  4. Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009;133(3):365–74. doi:10.1043/1543-2165-133.3.365.

    PubMed  Google Scholar 

  5. Nakata B, Wang YQ, Yashiro M, Nishioka N, Tanaka H, Ohira M, et al. Prognostic value of microsatellite instability in resectable pancreatic cancer. Clin Cancer Res. 2002;8(8):2536–40.

    CAS  PubMed  Google Scholar 

  6. Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, Raymond VM, et al. Risk of pancreatic cancer in families with Lynch syndrome. JAMA. 2009;302(16):1790–5. doi:10.1001/jama.2009.1529.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372(26):2509–20. doi:10.1056/NEJMoa1500596.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349(3):247–57. doi:10.1056/NEJMoa022289.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to William Laxton MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Laxton, W. (2017). Case 72: Pancreatic Ductal Adenocarcinoma with Medullary Features. In: Zaheer, A., Fishman, E., Pittman, M., Hruban, R. (eds) Pancreatic Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-52680-5_72

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-52680-5_72

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52678-2

  • Online ISBN: 978-3-319-52680-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics