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Disorders of the Sex Chromosomes and Sexual Development

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Fertility Preservation and Restoration for Patients with Complex Medical Conditions

Abstract

Sexual development is driven by a number of genetic factors, many of which are associated with the sex chromosomes. Typically, males have one X chromosome and one Y chromosome, while females have two X chromosomes. Differences in the number of sex chromosomes or pathogenic variants in genes involved in sex development often lead to differences in multiple body systems. Individuals with sex chromosome abnormalities and disorders of sexual development may be candidates for fertility preservation and discussion of genetic risk for future offspring. This chapter discusses gonadal function, fertility potential and preservation, and reproductive considerations for individuals with these disorders.

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Authors and Affiliations

  1. Ann and Robert Lurie Children’s Hospital, Chicago, Illinois, USA

    Allison L. Goetsch

  2. Northwestern University, Chicago, Illinois, USA

    Dana Kimelman & Teresa K. Woodruff

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  1. Allison L. Goetsch
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  2. Dana Kimelman
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  3. Teresa K. Woodruff
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Goetsch, A.L., Kimelman, D., Woodruff, T.K. (2017). Disorders of the Sex Chromosomes and Sexual Development. In: Fertility Preservation and Restoration for Patients with Complex Medical Conditions. Springer, Cham. https://doi.org/10.1007/978-3-319-52316-3_3

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