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Fertility Preservation

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Clinical Reproductive Medicine and Surgery

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Abstract

The use of fertility preservation strategies prior to chemo/radiotherapy treatments represents the only alternative to protect the chances for future reproduction in pre and post-pubertal girls. There are three available options: (a) embryo cryopreservation; (b) oocyte cryopreservation and (c) ovarian cortex cryopreservation. The first is the most established of the techniques, but it requires either a male partner or the use of donor sperm; oocyte freezing is no longer experimental and is gaining in popularity by avoiding the ethical concerns with embryo storage. Ovarian cortex freezing is still considered experimental and is considered for pre-pubertal girls and for women who cannot post-pone radio/chemotherapy. This chapter focuses on evaluating these options both for medical and social reasons. Specific indications for embryo, oocyte, and ovarian tissue cryopreservation are discussed.

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Abbreviations

Fertility preservation :

Branch of reproductive medicine aiming at preserving future fertility for patients stricken by cancer or other medical conditions requiring chemo/radiotherapy. Lately used also for preserving fertility for elective reasons

Chemotherapy :

Combination of drugs used for treating cancer or other medical conditions

Oocyte freezing :

Method to save oocytes at −196 °C

Embryo freezing :

Method to save embryos at −196 °C

Ovarian tissue freezing :

Method to save ovarian tissue at −196 º C

Controlled ovarian stimulation :

The use of fertility drugs to stimulate ovaries to produce multiple follicles

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University Fertility Center, New Haven, CT, USA

    Pasquale Patrizio MD & Emanuela Molinari PhD

  2. Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Tommaso Falcone MD

  3. Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA

    Lynn M. Westphal MD

Authors
  1. Pasquale Patrizio MD
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  2. Emanuela Molinari PhD
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  3. Tommaso Falcone MD
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  4. Lynn M. Westphal MD
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Correspondence to Pasquale Patrizio MD .

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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio, USA

    Tommaso Falcone

  2. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA

    William W. Hurd

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Patrizio, P., Molinari, E., Falcone, T., Westphal, L.M. (2017). Fertility Preservation. In: Falcone, T., Hurd, W. (eds) Clinical Reproductive Medicine and Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-52210-4_13

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