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Understanding the Cochlea pp 253–286Cite as

Ion and Fluid Homeostasis in the Cochlea

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Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 62))

Abstract

The transduction of sound into nerve impulses requires an ionic environment that depends on a variety of ion transport processes in epithelial and endothelial cells of the cochlea. Specific ion transport functions occur in specific cell types that coordinate the production and maintenance of endolymph, which is the fluid in the lumen of the cochlear duct that supports the sensory transduction process. The critical nature of these ion transport processes is underscored by observations of hearing loss when ion transport mechanisms malfunction as a result of mutations, drug exposure, or hormonal imbalance. This chapter describes our basic understanding of salient ion transport processes and their regulation by hormones and other regulatory pathways.

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Acknowledgements

This work was supported by Grant R01-DC012151 from the National Institute on Deafness and Other Communication Diseases, National Institutes of Health, and by the Kansas State University College of Veterinary Medicine.

Compliance with Ethics Requirements Philine Wangemann declares that she has no conflict of interest. Daniel C. Marcus declares that he has no conflict of interest.

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Authors and Affiliations

  1. Cell Physiology Laboratory, Kansas State University, Manhattan, KS, 66506, USA

    Philine Wangemann

  2. Cellular Biophysics Laboratory, Kansas State University, Manhattan, KS, 66506, USA

    Daniel C. Marcus

Authors
  1. Philine Wangemann
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  2. Daniel C. Marcus
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Correspondence to Philine Wangemann .

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Editors and Affiliations

  1. Cochlear and Auditory Brainstem Physiology, Department of Neuroscience, School of Medicine and Health Sciences and Cluster of Excellence Hearing4all, Research Centre Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany

    Geoffrey A. Manley

  2. Section of Physiological Acoustics and Communication, Faculty of Medicine, University of Tübingen, Tübingen, Germany

    Anthony W. Gummer

  3. Department of Biology, University of Maryland, College Park, Maryland, USA

    Arthur N. Popper

  4. Loyola University Chicago, Chicago, Illinois, USA

    Richard R. Fay

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Wangemann, P., Marcus, D.C. (2017). Ion and Fluid Homeostasis in the Cochlea. In: Manley, G., Gummer, A., Popper, A., Fay, R. (eds) Understanding the Cochlea. Springer Handbook of Auditory Research, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-319-52073-5_9

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